Protein corona change the drug release profile of nanocarriers: The “overlooked” factor at the nanobio interface

Behzadi, Shahed; Serpooshan, Vahid; Sakhtianchi, Ramin; Müller, Beate; Landfester, Katharina; Crespy, Daniel; Mahmoudi, Morteza

doi:10.1016/j.colsurfb.2014.09.009

Cited by 147 publications

(118 citation statements)

References 27 publications

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“…The postulated obstruction of drug release by the formation of a protein corona surrounding the donor particles [24] does not seem to play a crucial role in our release studies with fenofibrate.…”

Section: Accepted Manuscriptmentioning

confidence: 96%

“…This suggests either that not enough lipophilic acceptors were available for the transfer of lipophilic drug in serum and blood, or that the transfer was hampered by serum or blood components, e.g. proteins due to formation of a corona around the donor particles [24,25]. In order to elucidate the underlying phenomenon rapeseed oil nanoemulsion was added to the mixture of fenofibrate loaded-donor particles and porcine blood (1+9) after 4…”

Section: Drug Release Studies In Porcine Bloodmentioning

confidence: 99%

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Drug release studies from lipid nanoparticles in physiological media by a new DSC method

Roese

Bunjes

2017

Journal of Controlled Release

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Section: Accepted Manuscriptmentioning

confidence: 96%

Section: Drug Release Studies In Porcine Bloodmentioning

confidence: 99%

Drug release studies from lipid nanoparticles in physiological media by a new DSC method

Roese

Bunjes

2017

Journal of Controlled Release

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“…Various previous studies on protein-NP interactions were often performed under static conditions, 38 while NPs are often administrated through intravenous injection and immediately interact with blood protein under various shear stresses in the hydrodynamic body conditions. It is known that blood flow …”

Section: Static and Fluidic Conditionsmentioning

confidence: 99%

Protein corona: a new approach for nanomedicine design

Nguyen¹,

Lee²

2017

IJN

521

343

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After administration of nanoparticle (NP) into biological fluids, an NP–protein complex is formed, which represents the “true identity” of NP in our body. Hence, protein–NP interaction should be carefully investigated to predict and control the fate of NPs or drug-loaded NPs, including systemic circulation, biodistribution, and bioavailability. In this review, we mainly focus on the formation of protein corona and its potential applications in pharmaceutical sciences such as prediction modeling based on NP-adsorbed proteins, usage of active proteins for modifying NP to achieve toxicity reduction, circulation time enhancement, and targeting effect. Validated correlative models for NP biological responses mainly based on protein corona fingerprints of NPs are more highly accurate than the models solely set up from NP properties. Based on these models, effectiveness as well as the toxicity of NPs can be predicted without in vivo tests, while novel cell receptors could be identified from prominent proteins which play important key roles in the models. The ungoverned protein adsorption onto NPs may have generally negative effects such as rapid clearance from the bloodstream, hindrance of targeting capacity, and induction of toxicity. In contrast, controlling protein adsorption by modifying NPs with diverse functional proteins or tailoring appropriate NPs which favor selective endogenous peptides and proteins will bring promising therapeutic benefits in drug delivery and targeted cancer treatment.

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“…Liposomes can undergo shrinkage due to osmotic forces and may undergo a burst-release effect upon entering the blood, resulting in rapid drug release (Wolfram et al, 2014b). In contrast, protein binding on NPs has been shown to delay drug release, which prevented drug diffusion through the NP matrix (Paula et al, 2013) and reduced the burst effect (Behzadi et al, 2014). …”

Section: Considerations Of the Biomolecular Corona For Np-based Targementioning

confidence: 99%

Biomolecular corona on nanoparticles: a survey of recent literature and its implications in targeted drug delivery

2014

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Achieving controlled cellular responses of nanoparticles (NP) is critical for the successful development and translation of NP-based drug delivery systems. However, precise control over the physicochemical and biological properties of NPs could become convoluted, diminished, or completely lost as a result of the adsorption of biomolecules to their surfaces. Characterization of the formation of the “biomolecular” corona has thus received increased attention due to its impact on NP and protein structure as well as its negative effect on NP-based targeted drug delivery. This review presents a concise survey of the recent literature concerning the importance of the NP-biomolecule corona and how it can be utilized to improve the in vivo efficacy of targeted delivery systems.

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Protein corona change the drug release profile of nanocarriers: The “overlooked” factor at the nanobio interface

Cited by 147 publications

References 27 publications

Drug release studies from lipid nanoparticles in physiological media by a new DSC method

Drug release studies from lipid nanoparticles in physiological media by a new DSC method

Protein corona: a new approach for nanomedicine design

Biomolecular corona on nanoparticles: a survey of recent literature and its implications in targeted drug delivery

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