Protein A tangential flow affinity membrane cartridge for extracorporeal immunoadsorption therapy

A Nonsurgical Technique for Blood Access in Extracorporeal Affinity Adsorption of Antibodies in Rats

“…Appropriate animal models are therefore of the utmost importance. According to the literature, extracorporeal affinity adsorption has previously been conducted in primates (18), dogs (19), cats (20), and rabbits (21). We used rats because they are well characterized, and syngeneic tumor models in inbred strains are available.…”

Click chemistry: A route to designing and preparing pseudo-biospecific immunoadsorbent for IgG adsorption

“…As shown in Fig. 11, only the peaks at the mass-to-charge (m/z) ratio of 24,779 and 49,623, which are the characteristic peaks of IgG with different charge [38], can be clearly observed. It means that the designed and prepared immunoadsorbent Sep-triazoleHis possesses the ability of selectively separating IgG from human plasma.…”

Staphylococcusaureus protein A as a means of assessing sperm penetrability in cervical mucus in vitro

“…SPA has a high affinity for the Fc portion of IgG and IgG-containing immune complexes, which can be selectively removed via extracorporeal exposure of seminal plasma to SPA [9]. Immobilized protein A adsorbents have been extensively used for the purification and removal of human IgG from the serum in the treatment of immune-related diseases [10]. This protein has been tested in vivo and has proven successful in the treatment of antibody-induced nephritis, thrombocytopenia, and rheumatoid arthritis [11].…”