Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats

Ke, Yixin; Yu, Kaihang; Zeng, Weiliang; Guojun, Lian

doi:10.1590/s0102-865020190070000006

Cited by 7 publications

(7 citation statements)

References 36 publications

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“…However, due to minor changes in serum creatinine level in cadmium-treated animals, it can be concluded that this metal is able to cause moderate to mild renal failure. In line with our findings, the destructive effects of cadmium on renal tissue have been reported in several studies (19,20). This evidence might be attributed to the alterations in the GFR, the threshold of tubular re-absorption, and renal blood flow.…”

Section: Discussionsupporting

confidence: 92%

Effects of Pistacia atlantica Subsp. Kurdica on Cadmium-Induced Oxidative Damage in Rat Kidney

Kohnepoushi

Dastan

Nili‐Ahmadabadi

2020

Avicenna J Pharm Res

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Background: Pistacia atlantica kurdica has recently been shown to possess free radical scavenging ability. The current study aims to investigate the protective effect of this plant against cadmium-induced nephrotoxicity. Methods: Thirty-six rats were divided into 6 groups (6 in each), and treated as follows: group 1 received normal saline (control group), group 2 (positive control) received cadmium by drinking water (100 mg/ L/d), group 3 received 200 mg/kg of P. atlantica extract, and groups 4-6 received cadmium as well as 50, 100 and 200 mg/kg/d of P. atlantica extract (orally), respectively. After 2 weeks, oxidative damage and renal function markers were assayed by standard methods. Results: In cadmium group, a significant increase was observed in serum blood urea nitrogen (BUN) (P<0.01) and lipid peroxidation (LPO) level of renal tissue (P<0.001) and a remarkable decrease was found in total thiol molecules (TTM) of the kidney (P<0.001). Despite the decreased renal antioxidant capacity, these changes were not significant. P. atlantica extract improved the LPO, TTM, and histopathological changes in renal tissue. Conclusion: In this study, although the P. atlantica extract did not have a significant effect on cadmiuminduced renal dysfunction, it did improve the oxidative/antioxidant balance in renal tissue.

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Section: Discussionsupporting

confidence: 92%

Effects of Pistacia atlantica Subsp. Kurdica on Cadmium-Induced Oxidative Damage in Rat Kidney

Kohnepoushi

Dastan

Nili‐Ahmadabadi

2020

Avicenna J Pharm Res

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“…Previous studies proved that Cd could lead to chronic kidney disease and bone injury [ 5 ]. After ingestion of contaminated water and food by a human or animal, Cd primarily aggregates in the form of Cd-metallothionein complex in the liver and kidneys, and its turnover rate is excessively slow, which can disrupt the stability of essential metals such as zinc (Zn) and cuprum (Cu), reduce the capacity of cells to purge reactive oxygen species (ROS), cause oxidative stress and inflammation, and ultimately undermine organ function [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Selenium Antagonizes Cadmium-Induced Inflammation and Oxidative Stress via Suppressing the Interplay between NLRP3 Inflammasome and HMGB1/NF-κB Pathway in Duck Hepatocytes

Cao

Yang

Lin

et al. 2022

IJMS

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Cadmium (Cd) is a toxic heavy metal that can accumulate in the liver of animals, damaging liver function. Inflammation and oxidative stress are considered primary causes of Cd-induced liver damage. Selenium (Se) is an antioxidant and can resist the detrimental impacts of Cd on the liver. To elucidate the antagonism of Se on Cd against hepatocyte injury and its mechanism, duck embryo hepatocytes were treated with Cd (4 μM) and/or Se (0.4 μM) for 24 h. Then, the hepatocyte viability, oxidative stress and inflammatory status were assessed. The findings manifested that the accumulation of reactive oxygen species (ROS) and the levels of pro-inflammatory factors were elevated in the Cd group. Simultaneously, immunofluorescence staining revealed that the interaction between NOD-like receptor pyran domain containing 3 (NLRP3) and apoptosis-associated speck-like protein (ASC) was enhanced, the movement of high-mobility group box 1 (HMGB1) from nucleus to cytoplasm was increased and the inflammatory response was further amplified. Nevertheless, the addition of Se relieved the above-mentioned effects, thereby alleviating cellular oxidative stress and inflammation. Collectively, the results suggested that Se could mitigate Cd-stimulated oxidative stress and inflammation in hepatocytes, which might be correlated with the NLRP3 inflammasome and HMGB1/nuclear factor-κB (NF-κB) signaling pathway.

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“…Plant extracts were also found to exert wide protective effects against the third most dangerous heavy metal cadmium, with the results being confirmed by in vitro studies with using murine hepatocytes [ 3 ]. Additionally, an animal study showed the involvement of the Nrf2/Keap1 pathway into the protective action of Pyrantha fortuneana extract as the plant material, given both alone and coadministered with cadmium caused a significant increase in expression of Nrf2 and decrease in expression of Keap1 in the kidneys of rats vs. the control and Cd-exposed group, respectively [ 12 ].…”

Section: The Protective Properties Of Plant Preparations Against Tmentioning

confidence: 99%

“…The application of plant protection products has made another contribution to environmental contamination [ 6 – 9 ]. As it is not possible to improve the situation immediately, many people, i.e., industrial workers or farmers are still exposed to harmful substances like heavy metals [ 4 , 10 – 12 ], organic chemicals (e.g., CCl 4 ) [ 13 , 14 ], or pesticides and plant growth regulators [ 8 , 15 ]. Another problem results from introducing plenty of new pharmaceutical agents.…”

Section: Introductionmentioning

confidence: 99%

“…Under oxidative stress conditions, Nrf2 is released and translocated to the nucleus where it binds to ARE regions in DNA and stimulates antioxidant enzyme gene expression. Both Nrf2 and Keap1 as well proteins regulated by Nrf2, responsible for defence against antioxidant stress like HO-1 and γ -GCS, have been found to be disturbed by harmful factors (cadmium or high-fat diet) and regulated by plant preparations [ 12 , 61 ]. Plant origin substances have been reported to cause upregulation of Nrf2, HO-1, and γ -GCS in both nonexposed and Pb-exposed rats [ 62 ].…”

Section: Introductionmentioning

confidence: 99%

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The Great Healing Potential Hidden in Plant Preparations of Antioxidant Properties: A Return to Nature?

Kiełczykowska

Musik

2020

Oxidative Medicine and Cellular Longevity

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The application of chemicals in industry and agriculture has contributed to environmental pollution and exposure of living organisms to harmful factors. The development of new pharmaceutical agents enabled successful therapy of various diseases, but their administration may be connected with side effects. Oxidative stress has been found to be involved into etiology of numerous diseases as well as harmful action of drugs and chemicals. For some time, plant origin substances have been studied as potential protective agents alleviating toxicity of various substances and symptoms of diseases. The aim of the current review was to present the diversity of the research performed during the last five years on animal models. The outcomes showed a huge protective potential inherent in plant preparations, including alleviating prooxidative processes, strengthening antioxidant defence, ameliorating immune parameters, and reversing histopathological changes. In many cases, plant origin substances were proved to be comparable or even better than standard drugs. Such findings let us suggest that in the future the plant preparations could make adjuvants or a replacement for pharmaceutical agents. However, the detailed research regarding dose and way of administration as well as the per se effects needs to be performed. In many studies, the last issue was not studied, and in some cases, the deleterious effects have been observed.

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Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats

Cited by 7 publications

References 36 publications

Effects of Pistacia atlantica Subsp. Kurdica on Cadmium-Induced Oxidative Damage in Rat Kidney

Effects of Pistacia atlantica Subsp. Kurdica on Cadmium-Induced Oxidative Damage in Rat Kidney

Selenium Antagonizes Cadmium-Induced Inflammation and Oxidative Stress via Suppressing the Interplay between NLRP3 Inflammasome and HMGB1/NF-κB Pathway in Duck Hepatocytes

The Great Healing Potential Hidden in Plant Preparations of Antioxidant Properties: A Return to Nature?

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