Protective role of taurine against hepatotoxicity induced by pyrazinamide in rats

Taziki, Shohreh; Khori, Vahid; Jahanshahi, Mehrdad; Seifi, Akhtar; Babakordi, Fatemeh; Nikmahzar, Ensehgol Nikmahzar

doi:10.5455/njppp.2018.8.0101805022018

Cited by 4 publications

(7 citation statements)

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“…16 These findings were also supported by S.Taziki et al who used pyrazinamide to study the Hepatoprotective effects of taurine .In his study administration of PZ produced significant necrosis and inflammation in rats . 17 In our study there was also significant( p<0.05) improvement in histological parameters including necrosis, vascular congestion and infiltration of inflammatory cells by the use of Zn and BA in experimental group 4 in comparison with the Disease Control Group .The beneficial effects of BA n liver histology was in accordance with the findings of Abdullah et al 18 who proved antihepatotoxic activity of Betulinic acid due to its protective effect on antioxidant system and its membrane stabilizing activity . These findings were also in accordance with the study done by A. Ahangarpour 19 who studied the effects of Betulinic Acid on hepatic enzyme levels and histology on streptozotocin -nicotinamide -induced diabetic rats and showed that Betulinic acid pretreatment effectively reduces hepatic necrosis and inflammation .…”

Section: Discussionsupporting

confidence: 90%

Comparative effects of Silymarin and zinc complex of Betulinic acid on pyrazinamide induced Histopathological changes in Mice liver

Rehman¹,

Salim²,

Qayyum³

et al. 2021

PJMHS

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Introduction: Liver is an important organ in the body. Due to its role in metabolism of drugs it is also a major site of drug induced liver injury. Oxidative stress plays an important role in DILI therefore use of nti-oxidants has been proposed to combat liver injury . Objective of the Study: To measure and compare Hepatoprotective effects of Zinc complex of Betulinic acid and Silymarin due to their antioxidant effects on Pyrazinamide induced Hepatotoxicity in mice. Methodology: It was an experimental randomized control trial. The research was conducted at the Department of Pharmacology and Therapeutics and Multidisciplinary research laboratory at IIMCT with mutual collaboration of National Institute of Health (NIH) in Islamabad, Pakistan. Research was started after the official approval of synopsis by accredited Ethical Review Committee. Study duration was one year from 1 September 2020 to 31 august 2021. 24 adult Balb-C mice were randomly divided into four groups. Group 1 was Negative Control (NC) and did not receive any intervention. Oral pyrazinamide (500mg/kg) was administered for 28 days to the group 2 (disease control) alone and to group 3 and 4 in combination with Silymarin (100mg/kg) and Zinc complex of Betulinic Acid(1mg/kg) respectively. Mice were dissected after completion of experiment and liver samples were taken for Histopathological analysis. Hepatoprotective function of Silymarin and zinc complex of Betulinic acid was evaluated in group 3 and 4 by Histopathological changes. Results: Significant (p<0.05) changes were seen in parameters (necrosis, inflammatory cell infiltration and vascular congestion) among groups. Conclusion: This study proves protective effects of zinc complex of Betulinic acid and Silymarin on pyrazinamide induced hepatotoxicity. Key Words: Hepatotoxicity, Betulinic Acid, Silymarin, Pyrazinamide, Zinc, Tuberculosis

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Section: Discussionsupporting

confidence: 90%

Comparative effects of Silymarin and zinc complex of Betulinic acid on pyrazinamide induced Histopathological changes in Mice liver

Rehman¹,

Salim²,

Qayyum³

et al. 2021

PJMHS

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“…This result also confirms the results of previous studies on the hepatoprotective effects of taurine. [ 8,27,29,35–37 ] According to the results, taurine increased the level of regenerated GSH, which is in line with the results of previous studies on the cellular protective effects of taurine. [ 9 ] Decreased reduction of GSH levels in this test and also increased levels of MDA of them confirm the occurrence of oxidative stress in liver tissue these mechanisms of isotretinoin are new results.…”

Section: Discussionsupporting

confidence: 88%

“…This amino acid has a sulfonic acid group in its chemical structure. [ 6–8 ] Taurine causes various physiological effects, the most important of which are its antioxidant and radical scavenging effects. [ 9 ] it has been shown that taurine has beneficial effects on stabilizing cell membranes.…”

Section: Introductionmentioning

confidence: 99%

“…[ 9,11,12 ] The beneficial effects of this amino acid have been attributed to its role in stabilizing cellular membranes. [ 8,13 ] There are many reports on taurine's protective effects against different chemically‐induced hepatotoxicity. [ 14–16 ] The hepatoprotective effects of taurine against different toxins could be due to the antioxidant ability of this amino acid.…”

Section: Introductionmentioning

confidence: 99%

“…[ 14–16 ] The hepatoprotective effects of taurine against different toxins could be due to the antioxidant ability of this amino acid. [ 8 ] In many studies, it was reported that taurine increased glutathione (GSH) levels in biological systems. [ 17–19 ] Previous studies showed that several compounds that caused liver dysfunction in rats also changed urinary taurine levels.…”

Section: Introductionmentioning

confidence: 99%

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The hepatoprotective effects of taurine against oxidative stress induced by isotretinoin in rats

Taziki

Gholamzadeh

Hosseini

2022

J Biochem & Molecular Tox

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Liver disorders are one of the principal reasons for mortality in the world. Isotretinoin is a systemic retinoid that has been approved for therapy of acne vulgaris since 1982. This drug causes complications in the body. Evidence suggests that Isotretinoin might cause hepatotoxicity. Our research aimed to study the exact mechanism of hepatotoxicity induced by isotretinoin and the protective role of taurine in this toxicity. Biomarkers such as aspartate transaminase (AST) and alanine transaminase (ALT), superoxide dismutase, glutathione content (GSH), catalase, and malondialdehyde (MDA) were examined. Furthermore, pathological changes were evaluated. The results showed that oral administration of Isotretinoin induced hepatotoxicity as showed by elevation in ALT, AST, and MDA; also, it reduced intracellular GSH in rat liver tissue. Administration of taurine prevented the hepatotoxicity induced by isotretinoin in rats significantly.

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Hepatoprotective Pyrazinamide–Baicalein Cocrystal with a Rare Ratio of 7:3

Hao

et al. 2023

Crystal Growth & Design

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Exploring solid forms with low toxicity and high safety is a universal theme in drug research. This study developed a new cocrystal to optimize the severe hepatotoxicity of the first-line antituberculosis drug pyrazinamide (PZA). Baicalein (BCL) was chosen as the cocrystal former for its powerful hepatoprotective effect. The PZA–BCL cocrystal was structurally characterized by single-crystal X-ray diffraction (SCXRD), powder XRD (PXRD), differential scanning calorimetry–thermogravimetry (DSC-TG), and infrared (IR) spectroscopy. Meanwhile, the in vitro dissolution and in vivo pharmacokinetics and hepatotoxicity of the cocrystal were evaluated systematically. The results highlight that the BCL obtained tremendous improvements in water solubility, bioavailability, and hepatoprotective effect after cocrystal formation, hence almost removing the toxicity of PZA finally. Furthermore, it is worth noting that the molar ratio of 7:3 was first observed in the cocrystal, which is rare relative to the widely reported simple integer ratio of pharmaceutical cocrystals. The present research provides an interesting case for applying cocrystal technology in the field of drug safety.

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Protective role of taurine against hepatotoxicity induced by pyrazinamide in rats

Cited by 4 publications

References 0 publications

Comparative effects of Silymarin and zinc complex of Betulinic acid on pyrazinamide induced Histopathological changes in Mice liver

Comparative effects of Silymarin and zinc complex of Betulinic acid on pyrazinamide induced Histopathological changes in Mice liver

The hepatoprotective effects of taurine against oxidative stress induced by isotretinoin in rats

Hepatoprotective Pyrazinamide–Baicalein Cocrystal with a Rare Ratio of 7:3

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