Protective role of rosemary extract against Etoposide induced liver toxicity, injury and KI67 alterations in rats

Tousson, Ehab; Masoud, Ahmed; Hafez, Ezar; Almakhatreh, Majd

doi:10.21608/jbaar.2019.105884

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…Compared to control rats, etoposide therapy resulted in a significant increase in serum ALT, AST, and ALP, as well as a significant drop in albumen and total proteins, indicating liver injury. This finding is consistent with the findings of Nasr (2013), Al-Ameri (2017), Almakhatreh et al (2019, who reported that etoposide administration significantly increased the levels of ALT, AST, and ALP, as well as a significant decrease in albumen and total proteins in the serum, all of which are consistent with liver toxicity.…”

Section: Discussionsupporting

confidence: 92%

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Ameliorative potential role of Rosmarinus officinalis extract on toxicity induced by etoposide in male albino rats

2024

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The present work was showed to assess the effect of administration of rosemary extract on etoposide-induced toxicity, injury and proliferation in male rats were investigated. Forty male albino rats were arranged into four equal groups. 1st group, control; 2nd group, etoposide; 3rd group, co-treated rosemary & etoposide; 4th group, rosemary alone. In comparison to the control group, etoposide administration resulted in a significant increase in serum ALT, AST, ALP, total bilirubin, total protein, and gamma GT. In contrast; a significant decrease in albumin level in etoposide group as compared to G1. G3 revealed a significant decrease in AST, ALT, ALP, total protein and total bilirubin levels and a significant rise in albumin level when compared with G2. Serum levels of urea, creatinine, potassium ions, and chloride ions significantly increased; while sodium ions were significantly decreased in G2 when compared with G1. Also, there was an increase of MDA level for etoposide treated group with corresponding control rats. However, there was a remarkable significant decrease in SOD, GPX and CAT levels in G2 as compared to G1. There was a significant increase in serum hydrogen peroxide (H2O2) and Nitric oxide (NO) levels in group treated with etoposide when compared to control group. It was noticeable that administrated by rosemary alone either with etoposide had not any effect on the levels of H2O2 and Nitric oxide. Serum level of T3 and T4 was significantly increased in etoposide-administered rats in comparison with G1. The administration of rosemary, either alone or with etoposide, increased the serum levels of T3 and T4 significantly when compared to control rats. The gene expression analysis showed significant downregulation of hepatic SOD and GPx in (G2) when compared with (G1). The treatment with rosemary extract produced significant upregulation of the antioxidant enzymes mRNA SOD and GPx. MDA gene was increased in (G2) when contrasted with (G1). Treatment of the etoposide- induced rats with rosemary extract delivered significant decrease in MDA gene expression when compared with etoposide group. Rats treated with etoposide showed significant decline in hepatic Nrf2 protein expression, when compared with G1. While, supplementation of Etoposide- administered rats with the rosemary produced a significant elevation in hepatic Nrf2 protein levels. Additionally, the liver histological structure displayed noticeable degeneration and cellular infiltration in liver cells. It is possible to infer that rosemary has a potential role and that it should be researched as a natural component for etoposide-induced toxicity protection.

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Section: Discussionsupporting

confidence: 92%

“…Bile duct proliferation was also discovered. Similar changes were recorded by other investigators (Ravindra et al, 2012;Tousson et al, 2019). The production of free radicals is largely responsible for the enormous degenerative alterations produced by etoposide.…”

Section: Referencessupporting

confidence: 86%

Ameliorative potential role of Rosmarinus officinalis extract on toxicity induced by etoposide in male albino rats

2024

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“…Also, protein expression levels of α-SMA were decreased than TAA-moringa treated group. Our results agreed with Tousson et al, (2019). The protective effect of rosemary extract against TAA hepatotoxicity attributed to its richness in carnosic acid and rosmarinic acids which have antiinflammatory, anti-necrotizing and anti-fibrotic properties (Bahri et al, 2017).…”

Section: Discussionsupporting

confidence: 86%

Ameliorative effect of moringa and rosemary ethanolic extracts on thioacetamide-induced liver fibrosis in rats

Darweish

GabAllh

El-mashad

et al. 2021

Kafrelsheikh Veterinary Medical Journal

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Background/aim: Nutraceuticals have been extensively studied in recent years to find safe therapeutics of natural origin instead of relying only on pharmaceuticals. This study aimed to detect the hepato-protective role of moringa and rosemary ethanolic extracts on liver fibrosis induced by thioacetamide (TAA). Methods: This study was conducted on 60 male albino rats divided into four groups; control, TAA-group (received 100 mg/kg thioacetamide intraperitoneal twice /week for 18 weeks), moringa-protected group (received 300 mg/kg moringa ethanolic extract orally daily with TAA), rosemary-protected group (received 200 mg/kg rosemary ethanolic extract orally daily with TAA for 18 weeks). Results: There were significant increases in liver alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), malondialdehyde (MDA), and nitric oxide (NO) with significant decreases in reduced glutathione (GSH), superoxide dismutase (SOD) in the TAA-treated group with a high degree of fibrosis which extended to cirrhosis after 18 weeks. Meanwhile, both TAA-moringa and TAArosemary treated groups showed improvement in biochemical markers and fibrosis induced by TAA. Conclusion:This study proved that both moringa and rosemary could protect the liver against TAA-induced liver fibrosis and rosemary has greater protection than moringa.

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“…The present study was conducted to examine the ability of Tau to alleviate histopathological alterations in the liver and kidneys of rats treated with ETP. It has been demonstrated in a previous study that intraperitoneal injection of 1 mg/kg of ETP daily for four weeks induced hepatotoxicity evidenced by moderate atrophy and vacuolar degeneration of hepatocytes, pyknosis, marked cellular infiltrations, as well as marked congestion in hepatic veins (Tousson et al, 2019). These findings were in accordance with our results in which ETP administered intraperitoneally over a period of three days (14.7 mg/kg/day) for a total cumulative dose of 44 mg/kg and an observation period of 15 days resulted in hepatotoxicity characterized by congestion of hepatic blood vessels, chronic inflammatory cell infiltration predominantly lymphocytes, edema, vacuolar degeneration of hepatocytes, atypical cells, pyknosis of hepatocytes, and necrosis.…”

Section: Discussionmentioning

confidence: 95%

Histopathological Studies on the Effect of Taurine Against Etoposide-Induced Acute Liver and Kidney Toxicity in Female Albino Rats

Mohammed

Alhassani

2022

UKH J SCI ENG

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Etoposide (ETP) is a topoisomerase Ⅱ (TOP Ⅱ) inhibitor and one of the leading chemotherapeutic drugs for treating a wide variety of tumors. However, ETP induced hepatotoxicity and nephrotoxicity limits its clinical use. This study aims to investigate the protective potential of taurine (Tau) to mitigated histopathological changes in the liver and kidneys of female albino rats treated with ETP. A total of 18 female rats were divided into three groups; control group, ETP-exposed group received intraperitoneal injection of ETP on the first 3 days of the study for a total cumulative dose of 44 mg/kg to induce hepatotoxicity and nephrotoxicity, ETP + Tau group received ETP as stated previously with 400 mg/kg/day of Tau via oral gavage for 15 days. Sections from the liver and kidney were evaluated under light microscope and ETP-exposed group revealed vascular congestion, chronic inflammatory cell infiltration predominantly lymphocytes, edema, vacuolar degeneration, atypical cells, pyknosis, and necrosis while liver and kidney sections of rats treated with combination of ETP + Tau group exhibited marked alleviation of the histopathological damage. The study concludes that treatment with ETP induced marked structural damages in the liver and kidney and such morphological damages are effectively diminished by administering Tau.

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Protective role of rosemary extract against Etoposide induced liver toxicity, injury and KI67 alterations in rats

Cited by 5 publications

References 21 publications

Ameliorative potential role of Rosmarinus officinalis extract on toxicity induced by etoposide in male albino rats

Ameliorative potential role of Rosmarinus officinalis extract on toxicity induced by etoposide in male albino rats

Ameliorative effect of moringa and rosemary ethanolic extracts on thioacetamide-induced liver fibrosis in rats

Histopathological Studies on the Effect of Taurine Against Etoposide-Induced Acute Liver and Kidney Toxicity in Female Albino Rats

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