Protective Role of Endogenous Ovarian Hormones Against Learning and Memory Impairments and Brain Tissues Oxidative Damage Induced by Lipopolysaccharide

Pourganji, Masoume; Hosseini, Mahmoud; Soukhtanloo, Mohammad; Zabihi, Hoda; Hadjzadeh, Mousa‐Al‐Reza

doi:10.5812/ircmj.13954

Cited by 45 publications

(29 citation statements)

References 67 publications

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“…Using animal models, it has been indicated that administration of cytokines or other immune system stimuli including LPS deteriorate hippocampus-dependent learning and memory process 24 . Recently, the brain tissues oxidative damage was considered to have an important role in deleterious effects of LPS on learning and memory 16 . The cerebral cortex and hippocampus which play crucial roles in learning and cognition have been shown to be very sensitive to the oxidative stress 28 .…”

Section: Discussionmentioning

confidence: 99%

“…When the animals were entered completely into the dark compartment, the door was closed and an electrical shock (2 mA, 2 s) was delivered to the floor of the compartment. At 3, 24, 48 and 72 h later, the animals were again located in the light compartment for 15 s, after opening the guillotine door they gave access to the dark compartment within a period of 300 s. Then the time latency to enter into the dark room as well as the time spent by the animals in the light and dark compartments were recorded and defined as retention trail 16,17 .…”

Section: Passive Avoidance (Pa) Testmentioning

confidence: 99%

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Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole

Anaeigoudari

Shafei

Soukhtanloo

et al. 2015

Arq. Neuro-Psiquiatr.

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Inflammation and oxidative stress have important roles in memory impairment. The effect of 7-nitroindazole (7NI) on lipopolysaccharide (LPS)-induced memory impairment was investigated. Rats were used, divided into four groups that were treated as follows: (1) control (saline); (2) LPS; (3) 7NI-LPS; and (4) 7NI before passive avoidance (PA). In the LPS group, the latency for entering the dark compartment was shorter than in the controls (p < 0.01 and p < 0.001); while in the 7NI-LPS group, it was longer than in the LPS group (p < 0.01 and p < 0.001). Malondialdehyde (MDA) and nitric oxide (NO) metabolite concentrations in the brain tissues of the LPS group were higher than in the controls (p < 0.001 and p < 0.05); while in the 7NI-LPS group, they were lower than in the LPS group (p < 0.001 and p < 0.05, respectively). The thiol content in the brain of the LPS group was lower than in the controls (p < 0.001); while in the 7NI-LPS group, it was higher than in the LPS group (p < 0.001). It is suggested that brain tissue oxidative damage and NO elevation have a role in the deleterious effects of LPS on memory retention that are preventable using 7NI.

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Section: Discussionmentioning

confidence: 99%

Section: Passive Avoidance (Pa) Testmentioning

confidence: 99%

Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole

Anaeigoudari

Shafei

Soukhtanloo

et al. 2015

Arq. Neuro-Psiquiatr.

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“…The rat's estrous cycle is including proestrous, estrous, metaestrous and diestrous 9 . In proestrous phase, the estrogen levels are in high level.…”

Section: Discussionmentioning

confidence: 99%

“…Briefly, the rats were held in a non-stress position and quickly lavaged with approximately 1ml saline. Slides were read using light microscopy, and estrous categories were classified based on cytological characteristics 9 .…”

Section: Vaginal Cytologymentioning

confidence: 99%

Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats

Azizi-Malekabadi

Pourganji

Zabihi

et al. 2015

Arq. Neuro-Psiquiatr.

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The effects of tamoxifen (TAM) on anxiety and depression-like behavior in ovariectomized (OVX) and naïve female rats were investigated. The animals were divided into Sham-TAM, OVX-TAM, Sham and OVX groups. Tamoxifen (1 mg/kg) was administered for 4 weeks. In the forced swimming test, the immobility times in the OVX and Sham-TAM groups were higher than in the Sham group. In the open field, the numbers of central crossings in the OVX and Sham-TAM groups were lower than the number in the Sham group, and the number of peripheral crossings in the OVX group was lower than the number in the Sham group. In the elevated plus maze, the numbers of entries to the open arm among the animals in the Sham-TAM and OVX groups were lower than the number in the Sham group, while the number of entries to the open arm in the OVX-TAM group was higher than the number in the OVX group. It was shown that deletion of ovarian hormones induced anxiety and depression-like behavior. Administration of tamoxifen in naïve rats led to anxiety and depression-like behavior that was comparable with the effects of ovarian hormone deletion. It can be suggested that tamoxifen antagonizes the effects of ovarian hormones. It also seems that tamoxifen has anxiolytic effects on ovariectomized rats.Keywords: rat, ovariectomized, tamoxifen, depression, forced swimming test, open field, elevated plus maze. RESUMOForam investigados os efeitos do tamoxifeno (TAM) no comportamento semelhante a ansiedade de depressão de ratas ooforectomizadas (OVX) e controles. Os animais foram divididos em Sham-TAM, OVX-TAM, Sham e OVX groups. Tamoxifeno (1 mg/kg) foi administrado por quatro semanas. No teste de natação forçada, os tempos de imobilidade nos grupos OVX e Sham-TAM foram maiores que aqueles do grupo Sham. No campo aberto, os números de cruzamento no centro nos grupos OVX e Sham-TAM foram menores que aquele do grupo Sham, e o número dos cruzamentos na periferia no grupo OVX foi menor que o número no grupo Sham. No labirinto elevado, os números de entradas com braços abertos entre os animais nos grupos Sham-TAM e OVX foram menores do que aqueles do grupo Sham, enquanto o número de entradas com os braços abertos no grupo OVX-TAM foi maior que aquele no grupo OVX. Foi observado que a deleção dos hormônios ovarianos induziu comportamento similar a ansiedade e depressão. A administração de tamoxifeno em ratos controle induziu a um comportamento que era comparável aos efeitos da deleção do hormônio ovariano. Pode ser sugerido que o tamoxifeno antagoniza os efeitos dos hormônios ovarianos. Parece também que o tamoxifeno tem efeito ansiolítico nas ratas ooforectomizadas.Palavras-chave: rato, ooforectomia, tamoxifeno, depressão, teste de natação forçada, campo aberto, labirinto elevado.

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“…The absorbance of DTNB reagent was also read as the blank (B). Total thiol concentration (mM) was calculated using the following equation (37)(38)(39)(40):…”

Section: Biochemical Assessmentmentioning

confidence: 99%

Effects of melatonin and theanine administration on pentylenetetrazole-inducedseizures and brain tissue oxidative damage in ovariectomized rats

Choopankareh¹,

Vafaee²,

Shafei³

et al. 2015

Turk J Med Sci

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Background/aim: The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats. Materials and methods:The rats were divided into the following groups: 1) sham, 2) ovariectomized (OVX), 3) sham-PTZ, 4) OVX-PTZ, 5) sham-Mel/Thea-PTZ, and 6) OVX-Mel/Thea-PTZ. Groups 1-4 received saline, while groups 5 and 6 received a combination of Mel/Thea for 6 weeks. All animals except for those in groups 1 and 2 received a single injection of PTZ. Results:The OVX-PTZ group had higher generalized tonic-clonic seizure (GTCS) latency compared to the sham-PTZ group. Administration of Mel/Thea increased minimal clonic seizure and GTCS latencies in both the sham-Mel/Thea-PTZ and OVX-Mel/Thea-PTZ groups compared to the controls. Additionally, PTZ exposure increased malondialdehyde levels and reduced thiol concentrations in brain tissues of both the sham-PTZ and OVX-PTZ groups. Mel/Thea pretreatment resulted in MDA reduction and thiol increase in brain tissues. Conclusion:The results of this study demonstrated the antioxidant and anticonvulsant activities of Mel/Thea despite the presence or absence of ovarian hormones.

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Protective Role of Endogenous Ovarian Hormones Against Learning and Memory Impairments and Brain Tissues Oxidative Damage Induced by Lipopolysaccharide

Cited by 45 publications

References 67 publications

Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole

Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole

Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats

Effects of melatonin and theanine administration on pentylenetetrazole-inducedseizures and brain tissue oxidative damage in ovariectomized rats

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