Phytother. Res.
 1998
DOI: 10.1002/(sici)1099-1573(19980201)12:1<55::aid-ptr173>3.0.co;2-0
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Protective role of curcumin in ethanol toxicity

V. Rajakrishnan
1
,
Venugopal P. Menon
2
,
K. N. Rajashekaran
3

Abstract: The effect of curcumin on ethanol induced liver toxicity was evaluated. The increased levels of aspartate transaminase and alkaline phosphatase induced by ethanol were significantly lowered by curcumin. Elevated serum cholesterol, phospholipids and free fatty acids were observed in ethanol fed rats, but on curcumin treatment they decreased. We have also observed a marked decrease in the levels of thiobarbituric acid reactive substances in serum of alcoholic rats fed curcumin. Thus this study shows that curcumi… Show more

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Cited by 20 publications

(6 citation statements)
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“…In this context, curcumin has been shown to reduce serum lipid peroxides in healthy volunteers . We have also reported previously that curcumin decreases the serum levels of thiobarbituric acid reactive substances in ethanol-fed animals (Rajakrishnan et al, 1998), thus helping to restore the attachment to collagen.…”
Section: Discussionsupporting
confidence: 64%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In this context, curcumin has been shown to reduce serum lipid peroxides in healthy volunteers . We have also reported previously that curcumin decreases the serum levels of thiobarbituric acid reactive substances in ethanol-fed animals (Rajakrishnan et al, 1998), thus helping to restore the attachment to collagen.…”
Section: Discussionsupporting
confidence: 64%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In our previous study we have observed that curcumin offers protection against alcohol induced changes in the levels of serum lipid and marker enzymes (Rajakrishnan et al, 1998), the indicies of hepatic dysfunction.…”
Section: Discussionmentioning
confidence: 96%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Rats given ethanol showed elevated levels of blood cholesterol, phospholipids, and free fatty acids; however, these levels fell after curcumin therapy. In the serum of alcoholic rats administered curcumin, a notable decline in the levels of TBARS was also observed (Rajakrishnan et al, 1998). According to another research, ethanol causes fatty acid alterations in the liver that were prevented by curcumin.…”
Section: Effect Of Turmeric and Curcumin On Ethanol Toxicitymentioning
confidence: 88%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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