Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin

Elfadil, Hosny Abd; Mohamed, Ahmed A.; Behairy, Amany; Abdel‐Ghany, Heba M.; Amaym, Eman M.

doi:10.5455/ajvs.51618

Cited by 2 publications

(1 citation statement)

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“…The depletion of antioxidant enzymes such as SOD and CAT was attributed to levofloxacin-induced oxidative cell damage as a consequence of the production of reactive free radicals that overpower the antioxidant protection (Talla and Veerareddy, 2011). Our findings were consistent with previous results in levofloxacin-exposed rabbits (Khan et al, 2017) or immature albino rats (Abd Elfadil et al, 2019). Moreover, the observed data in this study corroborates with the work of Farid and Hegazy (2019) who reported that levofloxacin administration in rats displayed oxidative-stress represented by lessening in antioxidant enzymes (CAT & SOD) with high MDA concentrations.…”

Section: Discussionsupporting

confidence: 92%

Ameliorative Effect of Vitamin E and Panax ginseng Against Some Adverse Effects of Levofloxacin in Male Rats

Ibrahim¹,

Mahmoud²,

El-Mottleb³

et al. 2021

JAHP

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L evofloxacin is a third-generation, strictly synthetic flouroquinolone antibiotic. It has bactericidal activity against a wide variety of bacteria that are gram positive (G+ve) and gram negative (G-ve) (Al-Soufi and Al-Rek-abi, 2019). The principal target of quinolones is DNA gyrase, an essential bacterial enzyme (Abdel-Alim et al., 2017). Several studies have recorded that the most common serious effects associated with fluoroquinolones are headache, diarrhea, oxidative stress, hemolytic anemia, liver and kidney cellular damages (Owens and Ambrose, 2005;

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