Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary and uterus of rats

Abolaji, Amos O.; Ojo, Mercy; Afolabi, Tosin T.; Arowoogun, Mary D.; Nwawolor, Darlinton; Farombi, Ebenezer O.

doi:10.1016/j.cbi.2017.03.017

Cited by 122 publications

(71 citation statements)

References 51 publications

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“…6-shogaol, one of active principals of ginger, inhibits the ROS production, but elevates the release of certain anti-oxidant components as GSH via the nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf2) stimulation [42]. Further, 6-gingerol-rich element increase GSH production in the chlorpyrifos-exposed rats [43].…”

Section: Discussionmentioning

confidence: 99%

Modulatory Effect of Ginger Aqueous Extract against Imidacloprid-Induced Neurotoxicity in Rats

Farag

Fotoh

EL-Sayed

et al. 2019

Zagazig Veterinary Journal

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The current study was aimed to investigate neurotoxic impact of imidacloprid in rats and the potential modulatory role of Zingiber officinale Roscoe aqueous extract against such effects. Sixty male albino rats were randomly assigned into six groups (n = 10) as following: G1 is (-ve) control group (0.1 ml of distilled water for 90 days). G2 is (+ve) control group (1ml of aqueous extract of ginger (GAE) for 90 days). G3 group was administered with 0.1 ml of Imidacloprid (IMI) for 90 days. G4 group was administered with 1 ml of GAE for 2 weeks followed by administration of 0.1 ml of IMI/rat for 90 days. G5 group was administered with 0.1 ml of IMI for 90 days then 1ml of GAE for 2 weeks and the last group administered 0.1 ml of IMI and 1ml of GAE simultaneously for 90 days (G6) oral dosing of IMI and ginger aqueous extract was triple weekly. IMI exposure caused significant decrease in gamma amino butyric acid (GABA) level, significant increase in sorbitol dehydrogenase (SDH), significant depletion in glutathione (GSH), superoxide dismutase (SOD) was not affected by IMI exposure. IMI exposure upregulates toll like receptor 2 (TLR2) gene in the brain, intense immuno positive reactivity of TLR2 in the brain of IMI-treated group. Histopathologically, significant alterations in the brain were observed, such as neuronal degeneration, hemorrhages, necrosis, demyelination and gliosis. In conclusion, IMI neurotoxic effect could be modulated by the use of ginger aqueous extract.

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Section: Discussionmentioning

confidence: 99%

Modulatory Effect of Ginger Aqueous Extract against Imidacloprid-Induced Neurotoxicity in Rats

Farag

Fotoh

EL-Sayed

et al. 2019

Zagazig Veterinary Journal

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“…As a consequence, inhibition of cell death is regarded as an attractive approach to control cardiac disease. It has been reported that 6 G exerts cellular protective effects against radiation-induced cell damage [29], 4-hydroxynonenalinduced cells mortality [19], amyloid-b-induced pheochromocytoma cells injury [30], and chlorpyrifos-induced oxidative damage in the brain, ovary and uterus [18]. The cyto-protection of 6 G has also been elucidated in hypoxia-induced injury [20].…”

Section: Discussionmentioning

confidence: 99%

“…6-Gingerol (6 G) is a natural chemical compound isolated from ginger (Zingiber officinale). Specifically, 6 G has been indicated to possess potential efficacies against tumour [11][12][13][14][15][16], oxidative stress and inflammation [17][18][19]. Moreover, potent protection of 6 G against hypoxia/reoxygenation-induced injury has been recently elucidated.…”

Section: Introductionmentioning

confidence: 99%

6-Gingerol protects cardiocytes H9c2 against hypoxia-induced injury by suppressing BNIP3 expression

Ren¹,

Zhao²,

Ren³

2019

Artificial Cells, Nanomedicine, and Biotechnology

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Background: Cardiomyocytes loss is the predominant pathogenic characteristic in the hypoxia-induced injury. Meanwhile, it has been corroborated that Bcl-2 E1B 19-KDa interacting protein 3 (BNIP3) provokes apoptosis and autophagy. For moderating cardiomyocytes loss, we initially probed the cyto-protection effects of 6-Gingerol (6 G), meanwhile, its potential mechanisms associated with BNIP3 were elucidated in our studies. Methods: We pretreated cardiomyocytes H9c2 cells with 6 G at different concentrations (0-100 lM) before exposure to hypoxia. Thereafter, the cell viability, lactate dehydrogenase (LDH), apoptosis and protein expression were respectively assessed using cell counting kit-8 and methyl thiazolyl tetrazolium (MTT) assay, LDH assay kit, Annexin V-fluorescein isothiocyannate/propidium iodide (Annexin V-FITC/PI) apoptosis detection kit and Western blotting analysis. In addition, we also analyzed BNIP3 level after treatment. Moreover, we enforced the exogenous overexpression of BNIP3 and then evaluated the cell viability, apoptosis, and protein level again. Results: In our present work, we observed that the cell viability was promoted by 6 G in the hypoxiainduced H9c2 cells in a dose-dependent manner. Moreover, hypoxia-induced LDH release, apoptosis and autophagy were inhibited by 6 G pretreatment through promoting phosphorylation of PI3K, AKT and mTOR. Remarkably, accumulation of BNIP3 protein was significantly reduced by 6 G in hypoxia-induced H9c2 cells. Mechanistically, 6 G initiated the phosphorylated expression of PI3K, AKT and mTOR by down-regulating BNIP3 with reducing cardiomyocytes apoptosis and autophagy. Conclusion: Hypoxia-induced cardiomyocytes injury was ameliorated by 6 G through suppressing BNIP3 expression with triggering PI3K/AKT/mTOR signalling pathway.

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“…6‐Gingerol, which is one of the major pharmacologically active components of ginger, exhibits a wide variety of pharmacological actions, including immunomodulatory, anti‐inflammatory, antioxidant, antiapoptotic, antihyperglycemic, and antilipidemic effects . Therefore, interest in 6‐gingerol as a potential therapeutic has increased over the years due to its safety, efficacy, and control of multiple targets . Several studies have shown that 6‐gingerol may regulate plasma adiponectin level related to the beneficial effects in insulin sensitivity and hyperlipidemia .…”

Section: Introductionmentioning

confidence: 99%

6‐Gingerol Improves Ectopic Lipid Accumulation, Mitochondrial Dysfunction, and Insulin Resistance in Skeletal Muscle of Ageing Rats: Dual Stimulation of the AMPK/PGC‐1α Signaling Pathway via Plasma Adiponectin and Muscular AdipoR1

Liu

Yao

Wang

et al. 2019

Molecular Nutrition Food Res

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Scope This study investigates the dual actions of 6‐gingerol in stimulating both plasma adiponectin and muscular adiponectin receptor signaling in naturally ageing rats. Methods and results Twenty‐two‐month‐old male SD rats were treated with 6‐gingerol (0.2 mg kg–1, once daily) for 7 weeks. 6‐Gingerol can attenuate age‐associated high plasma triglyceride, glucose, and insulin concentrations under fasting conditions as well as suppress the increase in the HOMA‐IR index and inhibit the decrease of muscular p‐Akt/Akt protein in ageing rats, which indicates an improvement of systemic and muscular insulin sensitivity. Accompanying these changes, treatment with 6‐gingerol attenuates excessive triglyceride accumulation, enhances mitochondrial function, and promotes a transition from a fast‐ to slow‐fiber type and muscle oxidative metabolism in the red gastrocnemius of ageing rats. More importantly, 6‐gingerol not only increases the plasma and adipose tissue adiponectin concentrations, but also elevates muscular AdipoR1 expression and activates downstream AMPK phosphorylation as well as upregulates PGC‐1α in vivo and in vitro. Conclusion 6‐Gingerol may improve ectopic lipid accumulation, mitochondrial dysfunction, and insulin resistance in skeletal muscle of ageing rats. These effects rely, at least in part, on the elevated plasma adiponectin concentration and muscle AdipoR1 level to dually activate the AMPK/PGC‐1α signaling pathway.

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Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary and uterus of rats

Cited by 122 publications

References 51 publications

Modulatory Effect of Ginger Aqueous Extract against Imidacloprid-Induced Neurotoxicity in Rats

Modulatory Effect of Ginger Aqueous Extract against Imidacloprid-Induced Neurotoxicity in Rats

6-Gingerol protects cardiocytes H9c2 against hypoxia-induced injury by suppressing BNIP3 expression

6‐Gingerol Improves Ectopic Lipid Accumulation, Mitochondrial Dysfunction, and Insulin Resistance in Skeletal Muscle of Ageing Rats: Dual Stimulation of the AMPK/PGC‐1α Signaling Pathway via Plasma Adiponectin and Muscular AdipoR1

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