Protective impact of resveratrol in experimental rat model of hyperoxaluria

Oksay, Taylan; Yunusoğlu, Sedat; Calapoğlu, Mustafa; Candan, İbrahim Aydın; Onaran, İbrahim; Ergün, Osman; Özorak, Alper

doi:10.1007/s11255-017-1534-x

Cited by 9 publications

(9 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In other works, resveratrol at 5 mg/kg and 10 mg/kg was investigated for its litholytic effect on CaOx [17,18]. After treatment with resveratrol, a significant reduction in ROS, serum MDA level, and the number of urine CaOx crystals has been reported and approved [17,18]. The formation of CaOx crystals was correlated with the expression of OPN and hyaluroran (HA), which was supported by previous evidence [18,26,27].…”

Section: Resveratrolsupporting

confidence: 66%

“…Several flavonoids and stilbenes such as apigenin, catechin, (-)-epicatechin, curcumin, rutin, hesperidin, resveratrol, hyperoside, and quercetin (Figure 1) have been investigated for their potential to inhibit the formation of kidney stones [2,[9][10][11][12][13][14][15][16][17][18][19][20]. These authors investigated the anti-lithiasis effect of these bioactive compounds by in vitro and in vivo studies on kidney stones.…”

Section: Litholytic Activity Of Flavonoids and Stilbenesmentioning

confidence: 99%

“…The anti-lithiasis effect of rutin, apigenin, catechin, curcumin, resveratrol, and quercetin was reported by several investigators (Tables 1 and 2) using several animal models, as well as the oral administration of ethylene glycol (EG), EG with vitamin D3, EG with ammonium chloride, an oxalate rich diet, and MCM in rats [9][10][11][13][14][15][17][18][19][20][22][23][24].…”

Section: In Vivo Investigationsmentioning

confidence: 99%

Section: Resveratrolmentioning

confidence: 99%

See 3 more Smart Citations

Litholytic Activities of Natural Bioactive Compounds and Their Mechanism Insights

et al. 2021

View full text Add to dashboard Cite

Urolithiasis is a disease characterized by the formation of stones, which are crystalline accretions that form in the urinary tract from minerals dissolved in the urine. Moreover, it is considered to be a complex and multifactorial disease, requiring treatment. Unfortunately, current treatments are insufficient or may induce several side effects. In fact, medicinal plants are among the anti-litholytic treatments that are strongly recommended by many studies. Indeed, these natural resources contain bioactive molecules of different natures, such as flavonoids, terpenoids, alkaloids, and phenolic acids, which have recently demonstrated very important anti-litholytic effects. The molecular mechanisms involved are multiple and variable, and can reach cellular and molecular levels. In this review, we have discussed in depth the work that has studied the bioactive molecules of medicinal plants and their major potential against urolithiasis. Scientific databases, including Web of Science, PubMed, and Google Scholar, were searched from their inception until April 2021.The cellular and molecular mechanisms are presented and discussed. Some mechanisms of action related to these bioactive compounds are highlighted. This review could provide a scientific starting point for further studies on urolithiasis and natural bioactive compounds, especially flavonoids.

show abstract

Section: Resveratrolsupporting

confidence: 66%

Section: Litholytic Activity Of Flavonoids and Stilbenesmentioning

confidence: 99%

Section: In Vivo Investigationsmentioning

confidence: 99%

Section: Resveratrolmentioning

confidence: 99%

See 2 more Smart Citations

Litholytic Activities of Natural Bioactive Compounds and Their Mechanism Insights

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The follows formulas were used: Lee's obesity index=[(Body weight (g) x1,000)1/3]/Body length (cm) (31,32); abdominal visceral fat index=[abdominal visceral fat mass (g)/body weight (g)] x 100% (30); and creatinine clearance rate (ml/min)=[(urine creatinine (µmol/l) x urine volume (ml/min)]/serum creatinine (µmol/l) (33).…”

Section: Methodsmentioning

confidence: 99%

Aldosterone is involved in the pathogenesis of obesity-related glomerulopathy through activation of Wnt/β-catenin signaling in podocytes

et al. 2018

View full text Add to dashboard Cite

Obesity-related glomerulopathy (ORG) is morphologically characterized by glomerulomegaly with or without observable focal segmental glomerulosclerosis under light microscope, with decreased podocyte density and number, and with increased foot‑process width observed under electron microscope. The severity of podocyte injury is correlated with the degree of proteinuria and renal dysfunction. However, the pathogenesis of ORG is not well understood. The aim of the present study was to explore the possible pathogenic role of aldosterone (ALDO) in ORG. In the in vivo animal experiments, body weight, Lee's obesity index, abdominal fat index, urinary protein excretion, average glomerular diameter were significantly increased, the mRNA and protein expression of podocyte‑associated molecules including nephrin, podocin, podoplanin and podocalyxin were significantly reduced, and the Wnt/β‑catenin signaling pathway was activated in ORG model mice compared with the Control mice, whereas the administration of spironolactone significantly ameliorated these effects. In the in vitro experiments on cultured podocytes, the mRNA and protein expression levels of the aforementioned podocyte‑associated molecules were significantly downregulated and the Wnt/β‑catenin signaling pathway was activated following ALDO stimulation, whereas eplerenone significantly attenuated all the above effects. Dickkopf‑related protein 1 (DKK1), an inhibitor of Wnt/β‑catenin signaling pathway, also reduced the effects of ALDO exposure on the expression of podocyte‑associated molecules. The present study hypothesized that ALDO may be involved in the pathogenesis of ORG through the activation of Wnt/β‑catenin signaling pathway in podocytes.

show abstract

Protective effect of pentoxifylline on oxidative renal cell injury associated with renal crystal formation in a hyperoxaluric rat model

et al. 2018

View full text Add to dashboard Cite

The aim of the study is to investigate the effects of pentoxifylline (PTX) on the renal tubular cell injury and stone formation in a hyperoxaluric rat model induced by ethylene glycol and its possible underlying mechanisms. The study was performed with 30 male Wistar rats and randomized into three groups of teen. The sham-control (group 1) received only drinking water orally. The EG/untreated (group 2) received drinking water containing 0.75% EG for 4 weeks orally. The EG/PTX treated (group 3) received drinking water containing 0.75% EG for 4 weeks orally and PTX. Urine and blood were collected to determine some parameters. The kidneys were also removed for histological examination. Serum and urinary parameters were significantly improved in the EG/PTX treated. In the EG/PTX-treated group, the MDA, TOS and MPO activity reduced and the TAS, SOD, CAT and GSH-Px activities were increased markedly compared with the group 2. In urine of the group 2 rats, a large number of CaOx crystals were displayed and most tubules that contained crystals were dilated and showed degeneration, necrosis, and desquamation of the lining epithelium. Only few CaOx crystals were r in EG/PTX-treated animal's urine. Mild tissue damage was observed in PTX-treated rats. iNOS expression was significantly elevated in the group 2. In contrast, in the EG/PTX-treated group, eNOS expression in renal tubular epithelial cells was increased. Current study indicates that PTX may partially reduce renal tubular injury resulting from hyperoxaluria-induced oxidative and nitrosative stress.

show abstract

Protective impact of resveratrol in experimental rat model of hyperoxaluria

Cited by 9 publications

References 38 publications

Litholytic Activities of Natural Bioactive Compounds and Their Mechanism Insights

Litholytic Activities of Natural Bioactive Compounds and Their Mechanism Insights

Aldosterone is involved in the pathogenesis of obesity-related glomerulopathy through activation of Wnt/β-catenin signaling in podocytes

Protective effect of pentoxifylline on oxidative renal cell injury associated with renal crystal formation in a hyperoxaluric rat model

Contact Info

Product

Resources

About