2015
DOI: 10.1038/srep15553
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Abstract: Staphylococcus aureus (S. aureus) is an opportunistic bacterial pathogen responsible for a diverse spectrum of human diseases, resulting in considerable yearly mortality rates. Due to its rapid acquisition of antibiotic resistance, it becomes increasingly difficult to cure S. aureus infections with conventional antibiotics. Immunotherapy represents a promising alternative strategy to prevent and/or treat the infection. In the present study, passive immunization with polyclonal antibodies targeting three possib… Show more

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Cited by 19 publications
(15 citation statements)
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“…Furthermore, antimicrobial therapy for this disease has been increasingly challenging due to drug resistance ( Virdis et al, 2010 ). Among the etiological agents, Staphylococcus aureus is the most important and prevalent contagious mammary pathogen, and it causes other clinical infections ranging in severity from mild to fatal, including dermonecrotic skin infection, pneumonia, sepsis, and endocarditis ( de Almeida et al, 2013 ; Zhang et al, 2015 ). The remarkable ability of S. aureus to transmit and acquire resistance to currently available antibiotics further amplifies the gravity of infections, including mastitis, caused by this pathogen, especially multi-drug-resistant strains, such as methicillin-resistant S. aureus (MRSA) ( Tam et al, 2007 ; Ciustea et al, 2012 ).…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, antimicrobial therapy for this disease has been increasingly challenging due to drug resistance ( Virdis et al, 2010 ). Among the etiological agents, Staphylococcus aureus is the most important and prevalent contagious mammary pathogen, and it causes other clinical infections ranging in severity from mild to fatal, including dermonecrotic skin infection, pneumonia, sepsis, and endocarditis ( de Almeida et al, 2013 ; Zhang et al, 2015 ). The remarkable ability of S. aureus to transmit and acquire resistance to currently available antibiotics further amplifies the gravity of infections, including mastitis, caused by this pathogen, especially multi-drug-resistant strains, such as methicillin-resistant S. aureus (MRSA) ( Tam et al, 2007 ; Ciustea et al, 2012 ).…”
Section: Introductionmentioning
confidence: 99%
“…A multivalent toxoid vaccine can also be combined with surface antigens to induce both toxin neutralization and opsonophagocytic activity. A recent report indicates that treatment of mice with a combination of polyclonal antibodies against SEB, Hla, and the manganese transport protein C (MntC) reduced the levels of bacteremia (31). A multivalent toxoid-based vaccine would likely provide protection by limitation of the severity of disease rather than prevention of infection with S. aureus.…”
Section: Discussionmentioning
confidence: 99%
“…The antibody opsonophagocytic killing assay was carried out as described previously with appropriate modifications [29]. Briefly, the Human promyelocytic leukemia cells line (HL-60, ATCC: CCL-240) were differentiated into granulocyte-like cells in growth medium containing 0.8% N,N-dimethylformamide (Sigma-Aldrich, St Louis, MO, USA) for 4 days.…”
Section: Opsonophagocytic Killing Assaymentioning
confidence: 99%
“…Hemolytic activity assay and intestinal toxin activity assay were carried out based on a method established by us previously [29]. Briefly, for hemolytic activity assay, rabbit erythrocyte suspension in PBS (1%) was mixed with Hla, mHla and Hla pre-incubated with rFSAV-pcAb or negative-pcAb for 30 min.…”
Section: Hemolytic Activity Assay and Intestinal Toxin Activity Assaymentioning
confidence: 99%