Protective effects of ursolic acid and oleanolic acid in leukemic cells

Ovesná, Z; Kozics, Katarína; Slameñová, D

doi:10.1016/j.mrfmmm.2006.03.008

Cited by 109 publications

(59 citation statements)

References 32 publications

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“…Chen et al (2002) reported the chemopreventive potential of this compound based on its ability to inhibit superoxide production in leukocytes under induced oxidative stress. This antioxidant activity may be related to antitumor activity, as suggested most recently by Ovesná et al (2006). These authors showed that triterpenes can inhibit DNA strand breaks induced by hydrogen peroxide in leukemic cells.…”

Section: Discussionmentioning

confidence: 67%

Antimutagenic action of the triterpene betulinic acid isolated from Scoparia dulcis (Scrophulariaceae)

et al. 2015

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ABSTRACT. The mutagenic and antimutagenic activities of triterpene betulinic acid {3b-3-hydroxy-lup-20(29)-en-28-oic} isolated from the roots of Scoparia dulcis (Scrophulariaceae) were analyzed using the somatic mutation and recombination test (SMART) in the wings of Drosophila melanogaster. The mutagenic potential of betulinic acid was evaluated at 3 different concentrations (1.64, 3.28, and 6.57 mM). Antimutagenic activity evaluation was performed by co-treatment trials in which the flies received betulinic acid at 3 different concentrations in addition to 10 mM pro-mutagenic urethane. The results demonstrated that betulinic acid was not capable of causing DNA damage. However, the frequency of small single spots, large spots, and twin spots was significantly reduced. In the high bioactivation cross, betulinic acid was significantly active and exerted enhanced antimutagenic activity, possibly as a desmutagen.

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Section: Discussionmentioning

confidence: 67%

Antimutagenic action of the triterpene betulinic acid isolated from Scoparia dulcis (Scrophulariaceae)

et al. 2015

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“…This result suggests that the isolated acids of M. hirsuta induce an adaptive cell response, increasing their antioxidant defense mechanisms (Martin-Aragón et al 2001). Similarly, Ovesná et al (2006) and Tsai and Yin (2008) reported that both acids could protect cell lineages against the harmful effects of H 2 O 2 .…”

Section: Phytochemistry and Toxicity Of Mansoa Hirsuta 323mentioning

confidence: 88%

Evaluation of cytogenotoxicity, antioxidant and hypoglycemiant activities of isolate compounds from Mansoa hirsuta D.C. (Bignoniaceae)

Pereira

Queiroz

Siqueira

et al. 2017

An. Acad. Bras. Ciênc.

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Mansoa hirsuta (Bignoniaceae) is a native plant from caatinga in Brazilian semiarid. This plant has been locally used as antimicrobial and hypoglycemiant agents, but their action mechanisms and toxicity remain largely unknown. Therefore, we evaluated the composition and antioxidant, cytoprotective and hypoglycemiant effects of raw extract, fractions and compounds from leaves of M. hirsuta. The cytogenotoxic effects of ursolic and oleanolic acids, the main phytotherapic components of this plant, were assessed. The raw extract and fractions presented steroids, saponins, flavonols, flavanonols, flavanones, xanthones, phenols, tannins, anthocyanins, anthocyanidins and flavonoids. The ethyl acetate fraction inhibited efficiently the cascade of lipid peroxidation while the hydroalcoholic fraction was richer in total phenols and more efficient in capturing 2,2-diphenyl-1-picrylhydrazyl ( · DPPH) and 2,2'-azinobis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS ·+ ) radicals. The isolated fraction of M. hirsuta also inhibited the α-amylase activity. Cytotoxic effects were absent in both raw extract and fractions while ursolic+oleanolic acids were efficient in protecting cells after exposure to hydrogen peroxide. Moreover, this mixture of acid shad no significant interference on the mitotic index and frequency of nuclear and/ or chromosomal abnormalities in Allium cepa test. Therefore, M. hirsuta represents a potential source of phytochemicals against inflammatory and oxidative pathologies, including diabetes.

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“…The main constituents of its leaves are alkaloids, triterpenes, phenolic acids, coumarins, tannins, a cyclic peptide, and allantoin , as well as calycanthine and ursolic acid, which show antibacterial activity (do Nascimento et al, 2006). Furthermore, ursolic acid possesses antimutagenic, antitumor, aneugenic, and apoptotic properties (Dorai and Aggarwal, 2004;Liu, 2005;Ovesná et al, 2006;Aparecida Resende et al, 2006), and allantoin has excellent healing properties since it favors cell proliferation and accelerates skin regeneration (Ferreira et al, 2000). By contrast, calycanthine is considered to be a very powerful convulsant poison, causing effects similar to those of some neuropoisons such as strychnine (Adjibade et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Modulatory effect of Palicourea coriacea (Rubiaceae) against damage induced by doxorubicin in somatic cells of Drosophila melanogaster

Passos¹,

Ferreira²,

Vieira³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. Palicourea coriacea, popularly known as "douradinha", is a medicinal plant from the Brazilian Cerrado region used in folk medicine to treat kidney and urethral stones and kidney inflammation. We evaluated the cytotoxic, genotoxic, and possible antigenotoxic activities of an aqueous extract of P. coriacea on somatic cells of Drosophila melanogaster, using the somatic mutation and recombination test. We used third-stage larvae of D. melanogaster from a standard cross and a high bioactivation cross and tested 10 different doses of P. coriacea aqueous extract (5, 15, 25, 35, 50, 65, 80, 95, 110, and 125 mg/mL). Doxorubicin (0.125 mg/mL) was used as a positive control and distilled water as a negative control. None of the doses was lethal to the larvae. There was no genotoxic effect at 5, 10, or 15 mg extract/mL. However, a significant decrease in the frequency of spots induced by doxorubicin was observed when administered with P. coriacea aqueous extract at these same doses. We conclude that P. coriacea aqueous extract is not cytotoxic or genotoxic at these doses, but it does protect against the genotoxic action of doxorubicin.

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Protective effects of ursolic acid and oleanolic acid in leukemic cells

Cited by 109 publications

References 32 publications

Antimutagenic action of the triterpene betulinic acid isolated from Scoparia dulcis (Scrophulariaceae)

Antimutagenic action of the triterpene betulinic acid isolated from Scoparia dulcis (Scrophulariaceae)

Evaluation of cytogenotoxicity, antioxidant and hypoglycemiant activities of isolate compounds from Mansoa hirsuta D.C. (Bignoniaceae)

Modulatory effect of Palicourea coriacea (Rubiaceae) against damage induced by doxorubicin in somatic cells of Drosophila melanogaster

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