Protective effects of resveratrol on acute kidney injury in rats with sepsis

Luo, Congjuan; Liu, Feng; Bu, Quandong; Jiang, Wei; Zhang, Wei; Liu, Xuemei; Che, Lin; Luan, Hong; Zhang, Hui; Ma, Ruixia; Sun, Jianping; Xu, Yan

doi:10.5507/bp.2019.006

Cited by 23 publications

(24 citation statements)

References 22 publications

(22 reference statements)

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“…In this study, resveratrol treatment reversed the increased levels of IL-1β, IL-6, and TNF-α in kidney tissue and serum under hyperuricemic conditions, indicating that regulation of the inflammatory response may be a crucial part of resveratrol protecting against hyperuricemic nephropathy. Additionally, resveratrol has been demonstrated to alleviate acute kidney injury in lipopolysaccharide-treated mice [16] and to reduce the serum levels of TNF-α, IL-1β, and IL-6 in septic rats [17][18][19]. However, nuclear factor (NF)-related factor 2 signaling also has been shown to be regulated by resveratrol in https://doi.…”

Section: Discussionmentioning

confidence: 99%

Effects of resveratrol on the inflammatory response and renal injury in hyperuricemic rats

Ben-xi

Zheng

et al. 2021

Nutr Res Pract

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BACKGROUND/OBJECTIVES Hyperuricemic nephropathy is a common cause of acute kidney injury. Resveratrol can ameliorate kidney injury, but the explicit mechanism remains unclear. We investigated the effects of resveratrol on the inflammatory response and renal injury in hyperuricemic rats. MATERIALS/METHODS A rat model of hyperuricemic nephropathy was established by the oral administration of a mixture of adenine and potassium oxinate. Biochemical analysis and hematoxylin and eosin staining were performed to assess the rat kidney function. Enzyme-linked immunosorbent assays were performed to evaluate the immune and oxidative responses. RESULTS The expression levels of urine albumin and β2-microglobulin were significantly decreased after resveratrol treatment. In addition, the levels of serum creatinine and uric acid were significantly decreased in the resveratrol groups, compared with the control group. The levels of proinflammatory factors, such as interleukin-1β and tumor necrosis factor-α, in kidney tissue and serum were also increased in the hyperuricemic rats, and resveratrol treatment inhibited their expression. Moreover, the total antioxidant capacity in kidney tissue as well as the superoxide dismutase and xanthine oxidase levels in serum were all decreased by resveratrol treatment. CONCLUSIONS Resveratrol may protect against hyperuricemic nephropathy through regulating the inflammatory response.

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Section: Discussionmentioning

confidence: 99%

Effects of resveratrol on the inflammatory response and renal injury in hyperuricemic rats

Ben-xi

Zheng

et al. 2021

Nutr Res Pract

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“…Resveratrol upregulates PGC-1α, NRF1, NRF2 and Tfam leading to potentiation of mitochondrial biogenesis (100). In multiple studies using a CLP model of polymicrobial sepsis in rats, resveratrol treatment results in increased survival as well as decreased kidney injury associated with inhibition of NFκB (101,102). In a similar model of pediatric sepsis-induced kidney injury in young rats, resveratrol was shown to activate NRF2 and protect from injury (103).…”

Section: Natural Products That Induce Mitochondrial Biogenesismentioning

confidence: 98%

The Metabolic Basis of Immune Dysfunction Following Sepsis and Trauma

et al. 2020

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Critically ill, severely injured and high-risk surgical patients are vulnerable to secondary infections during hospitalization and after hospital discharge. Studies show that the mitochondrial function and oxidative metabolism of monocytes and macrophages are impaired during sepsis. Alternatively, treatment with microbe-derived ligands, such as monophosphoryl lipid A (MPLA), peptidoglycan, or β-glucan, that interact with toll-like receptors and other pattern recognition receptors on leukocytes induces a state of innate immune memory that confers broad-spectrum resistance to infection with common hospital-acquired pathogens. Priming of macrophages with MPLA, CPG oligodeoxynucleotides (CpG ODN), or β-glucan induces a macrophage metabolic phenotype characterized by mitochondrial biogenesis and increased oxidative metabolism in parallel with increased glycolysis, cell size and granularity, augmented phagocytosis, heightened respiratory burst functions, and more effective killing of microbes. The mitochondrion is a bioenergetic organelle that not only contributes to energy supply, biosynthesis, and cellular redox functions but serves as a platform for regulating innate immunological functions such as production of reactive oxygen species (ROS) and regulatory intermediates. This review will define current knowledge of leukocyte metabolic dysfunction during and after sepsis and trauma. We will further discuss therapeutic strategies that target leukocyte mitochondrial function and might have value in preventing or reversing sepsis-and trauma-induced immune dysfunction.

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“…Hence, the effect of resveratrol has been evaluated in AKI cases to determine its ameliorative properties, as well as its underlying molecular mechanisms. In separate studies, Wang et al and Luo et al showed that resveratrol reduced LPS‐mediated increases in pro‐inflammatory cytokines (IL‐6, IL‐1β, and TNF‐α) by suppressing the inositol‐requiring enzyme 1 (IRE1)‐NF‐κB pathway 62,63 . Moreover, resveratrol was shown to increase the levels of the anti‐inflammatory cytokine, IL‐10, in AKI 63 .…”

Section: Treatment Of Sepsis With Polyphenolic Compoundsmentioning

confidence: 99%

“…In separate studies, Wang et al and Luo et al showed that resveratrol reduced LPS‐mediated increases in pro‐inflammatory cytokines (IL‐6, IL‐1β, and TNF‐α) by suppressing the inositol‐requiring enzyme 1 (IRE1)‐NF‐κB pathway 62,63 . Moreover, resveratrol was shown to increase the levels of the anti‐inflammatory cytokine, IL‐10, in AKI 63 . Resveratrol has also been reported to exert protective effects against sepsis‐associated encephalopathy (SAE) by inhibiting the NLRP3/IL‐1𝛽 axis in LPS‐stimulated microglial cells in the hippocampus of SAE mice 64 .…”

Section: Treatment Of Sepsis With Polyphenolic Compoundsmentioning

confidence: 99%

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The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective

et al. 2020

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Sepsis and septic shock are still a leading cause of mortality and morbidity in intensive care units worldwide. Sepsis is an uncontrolled and excessive response of the innate immune system toward the invading infectious microbes, characterized by the hyper‐production of pro‐inflammatory mediators such as interleukin (IL)‐1β, IL‐6, tumor‐necrosis factor (TNF)‐α, and high‐mobility group box 1 (HMGB1). In severe sepsis, the overwhelming production of pro‐inflammatory cytokines and reactive oxygen species may compromise organ function and lead to the induction of abnormal apoptosis in different organs, resulting in multiple organ dysfunction syndrome and death. Hence, compounds that are able to attenuate inflammatory responses may have therapeutic potential for sepsis treatment. Understanding the pathophysiology and underlying molecular mechanisms of sepsis may provide useful insights in the discovery and development of new effective therapeutics. Therefore, numerous studies have invested much effort into elucidating the mechanisms involved with the onset and development of sepsis. The present review mainly focuses on the molecules and signaling pathways involved in the pathogenicity of sepsis. Additionally, several well‐known natural bioactive herbal compounds and phytochemicals, which have shown protective and therapeutic effects with regard to sepsis, as well as their mechanisms of action, are presented. This review suggests that these phytochemicals are able to attenuate the overwhelming inflammatory responses developed during sepsis by modulating different signaling pathways. Moreover, the anti‐inflammatory and cytoprotective activities of phytochemicals make them potent compounds to be included as complementary therapeutic agents in the diets of patients suffering from sepsis in an effort to alleviate sepsis and its life‐threatening complications, such as multi‐organ failure.

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Protective effects of resveratrol on acute kidney injury in rats with sepsis

Cited by 23 publications

References 22 publications

Effects of resveratrol on the inflammatory response and renal injury in hyperuricemic rats

Effects of resveratrol on the inflammatory response and renal injury in hyperuricemic rats

The Metabolic Basis of Immune Dysfunction Following Sepsis and Trauma

The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective

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