Protective effects of phenolic acid extract from ginseng on vascular endothelial cell injury induced by palmitate via activation of PI3K/Akt/eNOS pathway

Chen, Xuenan; Yao, Fan; Song, Jia; Fu, Baoyu; Sun, Guifan; Song, Xinying; Fu, Chunge; Jiang, Rui; Sun, Liwei

doi:10.1111/1750-3841.15071

Cited by 11 publications

(9 citation statements)

References 45 publications

(47 reference statements)

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“…In addition, it was found that ginseng has the effect of suppressing kidney failure by normalizing the vascular function of kidney tissue [ 57 ]. Consistent with the above observations, ginseng extract is known to inhibit lipid accumulation in cells and promote phosphorylation of PI3K/Akt/eNOS signaling pathways through overexpression of ET-1, thereby inhibiting endothelial cell damage due to hyperlipidemia [ 58 ]. In addition, ginsenoside Rb1 normalizes calcium metabolism in vivo and in vitro vascular smooth muscle cells.…”

Section: Panax Ginseng and Ginsenosides Against Cardiac Pathogenesis Of Covid-19mentioning

confidence: 57%

Possibility as role of ginseng and ginsenosides on inhibiting the heart disease of COVID-19: A systematic review

Hossain

Kim

2022

Journal of Ginseng Research

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Coronavirus has been spreading rapidly around the world since it broke out in China in 2019. Respiratory diseases caused by coronavirus infection cause various diseases ranging from asymptomatic subclinical infections to severe pneumonia and cardiovascular complications, leading to death. In this regard, natural products are being studied to prevent various diseases caused by COVID-19. In current review, we would like to present mechanisms related to the inhibition of heart disease in ginseng and ginsenoside against SARS-CoV-2. In many previous studies, ginseng and ginsenoside are known to have antioxidant, blood flow improvement, improvement of vascular and heart function, blood pressure control, suppression of myocardial infarction and heart failure, and antiarrhythmia. Therefore, ginseng and ginsenoside have a possibility to suppress cardiovascular complications caused by COVID-19. Many of research provide evidence for ginseng and ginsenoside as treatments for the risk of cardiovascular complications. However, in this review, more specific contents on the proposition of the efficacy of ginseng and ginsenoside for COVID-19 should be presented. Therefore, we hope that researches to reduce cardiovascular complications of ginseng and ginsenoside for COVID-19 should be presented to reduce mortality for COVID-19.

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Section: Panax Ginseng and Ginsenosides Against Cardiac Pathogenesis Of Covid-19mentioning

confidence: 57%

Possibility as role of ginseng and ginsenosides on inhibiting the heart disease of COVID-19: A systematic review

Hossain

Kim

2022

Journal of Ginseng Research

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“…Sinapic acid increased Akt phosphorylation in a dose-dependent manner. Chen et al (2020) reported that phenolic acids extracted from ginseng protect against vascular endothelial cell injury via the activation of the PI3K/Akt/eNOS pathway [ 35 ]. Yan et al (2020) reported that gallic acid attenuated vascular dysfunction and hypertension in angiotensin II-induced C57BL/6J mice by suppressing eNOS degradation [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Comparison of the Antihypertensive Activity of Phenolic Acids

Kim

Heo

et al. 2022

Molecules

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Phenolic acids, found in cereals, legumes, vegetables, and fruits, have various biological functions. We aimed to compare the antihypertensive potential of different phenolic acids by evaluating their ACE inhibitory activity and cytoprotective capacity in EA.hy926 endothelial cells. In addition, we explored the mechanism underlying the antihypertensive activity of sinapic acid. Of all the phenolic acids studied, sinapic acid, caffeic acid, coumaric acid, and ferulic acid significantly inhibited ACE activity. Moreover, gallic acid, sinapic acid, and ferulic acid significantly enhanced intracellular NO production. Based on the results of GSH depletion, ROS production, and MDA level analyses, sinapic acid was selected to study the mechanism underlying the antihypertensive effect. Sinapic acid decreases endothelial dysfunction by enhancing the expression of antioxidant-related proteins. Sinapic acid increased phosphorylation of eNOS and Akt in a dose-dependent manner. These findings indicate the potential of sinapic acid as a treatment for hypertension.

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“…F. H. Chen . These components have pharmacological effects such as cardiotonic, anti-oxidative stress, anti-myocardial ischemia, and immuno-enhancing function ( Hu et al, 2018 ; Chen et al, 2020 ). The structure can also be divided into panaxadiol, panaxatriol, and oleanolic acid types.…”

Section: Resultsmentioning

confidence: 99%

The Integrated Study on the Chemical Profiling to Explore the Constituents and Mechanism of Traditional Chinese Medicine Preparation Huatuo Jiuxin Pills Based on UPLC-Q-TOF/MSE and Network Pharmacology

Zhu

Tao

et al. 2022

Front. Mol. Biosci.

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Huatuo Jiuxin Pills (HJP), a traditional Chinese medicine (TCM) preparation, has been widely used to treat Cardiovascular Diseases (CVDs) for more than 20 years. However, there were still gaps in the study of chemical components and potential pharmacological effects in the HJP. In this study, ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MSE) combined with network pharmacology was used to comprehensively explore the chemical components in HJP and explore its potential active compounds and the mechanism for the treatment of CVDs. A total of 117 compounds, mainly including saponins, cholic acids, and bufadienolides, were rapidly identified and characterized. Simultaneously, the fragmentation mode and characteristic ion analysis of different types of representative compounds were carried out. Network pharmacology results showed that the more important active ingredients mainly include 5β‐hydroxybufotalin, 19 oxo‐cinobufagin, bufarenogin, etc. While, the main targets were PIK3CA, MAPK1, VEGFA and so on. Importantly, HJP has therapeutic effects on CVDs by acting on endocrine resistance, PI3K-Akt signaling pathway, HIF-1 signaling pathway, etc. In addition, molecular docking results showed that the core active ingredients with higher degrees in HJP have a strong affinity with the core targets of CVDs. The current work fills the gap in the chemical substance basis of HJP, and also facilitates a better understanding of the effective components, therapeutic targets, and signaling pathways of HJP in the treatment of CVDs.

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Protective effects of phenolic acid extract from ginseng on vascular endothelial cell injury induced by palmitate via activation of PI3K/Akt/eNOS pathway

Cited by 11 publications

References 45 publications

Possibility as role of ginseng and ginsenosides on inhibiting the heart disease of COVID-19: A systematic review

Possibility as role of ginseng and ginsenosides on inhibiting the heart disease of COVID-19: A systematic review

Comparison of the Antihypertensive Activity of Phenolic Acids

The Integrated Study on the Chemical Profiling to Explore the Constituents and Mechanism of Traditional Chinese Medicine Preparation Huatuo Jiuxin Pills Based on UPLC-Q-TOF/MSE and Network Pharmacology

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