Protective Effects of Petroselinum crispum (Parsley) Extract  Against Methotrexate-Induced Hepatotoxicity

Ertaş, Büşra; Turan, Feyza; Özbeyli, Dilek; Yanardağ, Refiye; Saçan, Özlem; Şener, Göksel

doi:10.26650/eurjbiol.2021.1023136

Cited by 8 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While the groups treated with n-BuOH fraction demonstrated a higher significant decrease (P< 0.01) of ALT level from (82.4 ± 2.1 to 41.5 ± 4.7 U/L) when compared with the toxic group, as shown in Figure 2 exhibited the treatment of mice with a high concentration (400 mg/kg) of each extract showed the highest reduction in ALT levels. These findings are in agreement with reported studies [19][20][21] .…”

Section: Alanine-aminotransferase (Alt) Levelsupporting

confidence: 94%

Chromatographic Isolation, Identification and Characterization of Some Chemical Constituents of Petroselinum Crispum Leaves and Evaluating as Hepatoprotective Agents

Metwally

El-Sayed²,

Morsi³

et al. 2022

Bulletin of Pharmaceutical Sciences. Assiut

View full text Add to dashboard Cite

Petroselinum crispum Mill. (family Apiaceae) is widely used as an essential spice due to its health benefits. This study aimed to investigate the constituents of P.crispum aerial parts and evaluate its hepatoprotective activity. Ethyl acetate and n-butanol fractions of P. crispum subjected to different chromatographic separation techniques. The compounds were identified on the basis of spectral data and compared with previously reported data. Also, the methanolic extract and n-butanol fraction were evaluated for in-vivo hepatoprotective activity against carbon tetrachloride (CCl 4 ) induced hepatotoxicity in mice (10 groups; 8 mice/group). All groups intraperitonially injected by CCl 4 (0.5mg/kg b.w., i.p.) in single dose at 11th day, the treated groups received (100, 200, 300, 400 mg/kg b.w.) of MeOH extract and BuOH fraction separately for 14 days. The results revealed that seven compounds were isolated from EtOAc and n-BuOH fractions which were identified as β-sitosterol (1), quercetin (2), isorhmentin (3), apigenin (4), apigenin-7-O-β-D-glucopyranoside (cosmosiin) (5), diosmetin-7-O-β-Dglucopyranoside ( 6), apigenin 7-O-β-D-apiofuranosyl (1→2)-β-D glucopyranoside (apiin) (7). On other hand, CCl 4induced hepatotoxicity cleared in severe liver damage, showed elevation of liver enzymes. The MeOH extract and n-BuOH fraction exhibited significant hepatoprotection in improvement liver enzymes, with a propensity to return to near-normal levels. So, P. crispum extracts are promising in-vivo hepatoprotective activity.

show abstract

Section: Alanine-aminotransferase (Alt) Levelsupporting

confidence: 94%

Chromatographic Isolation, Identification and Characterization of Some Chemical Constituents of Petroselinum Crispum Leaves and Evaluating as Hepatoprotective Agents

Metwally

El-Sayed²,

Morsi³

et al. 2022

Bulletin of Pharmaceutical Sciences. Assiut

View full text Add to dashboard Cite

show abstract

“…These compounds offer several health-promoting benefits like anti-inflammatory actions, cardiovascular health support, and anti-cancer properties. [8] In addition, it has been reported that parsley has antidiabetic effects [9][10][11] and protective effects against hepatotoxicity. [12] Another essential compound in parsley is carnosic acid.…”

Section: Resultsmentioning

confidence: 99%

Petroselinum crispum Extract Prevents Scopolamine‐Induced Lens Damage in Rats

Ertik,

Pazarbaşı,

Sener

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

Alzheimer's disease (AD) is a neurodegenerative disease that occurs especially in advanced ages. It reduces quality of life of both the patient and their relatives. In addition to its primary effects, AD causes metabolic defects and tissues are damaged due to these effects. Oxidative stress damages cells by disrupting antioxidant/oxidant balance in many tissues, especially due to AD. In individuals with AD and the elderly, lens tissue is damaged due to oxidative stress and may cause vision loss. Therefore, it is very important to investigate herbal products that both prevent/cure AD and reduce AD‐related oxidative stress, as they may have fewer side effects. In this study, the protective effects of parsley extract on lens tissues of experimental AD model induced by scopolamine were examined and evaluated through biochemical parameters. The result of biochemical experiments and principal component analysis, it was observed that parsley extract had a therapeutic effect by reducing oxidative stress in lens tissues of experimentally induced AD rats. It can be suggested that the phenolic and flavonoid‐rich content of parsley extract may have caused the reduction of oxidative damage in lens tissues and can be used to protect lens tissue against oxidative stress due to AD disease.

show abstract

“…In the present experiment, MTX administration significantly lowered tissue GSH in the induction group when compared to the negative control group. An animal study of Petroselinum crispum hepatoprotective effects in methotrexate-induced liver injury by B. Ertas et al showed comparable results by MTX administration (Ertas et al 2021). Additionally, MTX injection in a study in mice evaluating the hepatoprotective activity of vitamin C, significantly decreased the tissue level of GSH (Mohammed and Al-Gareeb 2021).…”

Section: Discussionmentioning

confidence: 95%

Astaxanthin affects oxidative stress biomarkers in methotrexate-induced hepatotoxicity

Hamdan

Kamal

Waheed

2022

ijhs

View full text Add to dashboard Cite

Methotrexate is a chemotherapeutic and immunosuppressive drug used in the treatment of cancer, psoriasis, rheumatoid arthritis and several other disorders. Its use predisposes to hepatotoxicity which is a serious side effect. The current study aimed to assess the oxidative-stress-causing potential of methotrexate to liver cells and evaluate the hepatoprotective activity of the potent antioxidant astaxanthin, by affecting the oxidative stress biomarkers GSH (glutathione), SOD (superoxide dismutase), CAT (catalase) and MDA (malondialdehyde). A model of methotrexate-induced liver toxicity was employed on male rats. Thirty-six rats were divided into six groups; a negative control group, methotrexate induction group given (20 mg/kg) I.P. on day 13, three groups pretreated with oral astaxanthin in ascending doses (50, 75 and 100 mg/kg) for 14 days before methotrexate, and a conventional therapy group pretreated with silymarin (200mg/kg). The use of methotrexate significantly decreased liver tissue GSH, SOD and CAT while significantly increasing MDA, compared to the negative control. On the other side, astaxanthin used in all three doses significantly normalized these biomarkers. This study revealed that since astaxanthin significantly increased GSH, SOD and CAT while decreasing MDA that minimizes oxidative stress, it could be used as pretreatment in patients treated with methotrexate to decrease its hepatotoxicity.

show abstract

Protective Effects of Petroselinum crispum (Parsley) Extract Against Methotrexate-Induced Hepatotoxicity

Cited by 8 publications

References 33 publications

Chromatographic Isolation, Identification and Characterization of Some Chemical Constituents of Petroselinum Crispum Leaves and Evaluating as Hepatoprotective Agents

Chromatographic Isolation, Identification and Characterization of Some Chemical Constituents of Petroselinum Crispum Leaves and Evaluating as Hepatoprotective Agents

Petroselinum crispum Extract Prevents Scopolamine‐Induced Lens Damage in Rats

Astaxanthin affects oxidative stress biomarkers in methotrexate-induced hepatotoxicity

Contact Info

Product

Resources

About