Protective effects of onion (<i>Allium cepa</i>) extract against doxorubicin-induced hepatotoxicity in rats

Mete, Rafet; Oran, Mustafa; Topçu, Birol; Öznur, Meltem; Şeber, Erdoğan Selçuk; Gedikbaşı, Asuman; Yetişyiğit, Tarkan

doi:10.1177/0748233713504807

Cited by 34 publications

(18 citation statements)

References 28 publications

(28 reference statements)

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“…Also, DOX caused high percentage of structural and numerical chromosome aberrations. These results are similar to the previous studies which provided evidence that DOX induced hepatotoxicity and chromosomal aberrations [29][30][31]. On the other hand, Herbs are rich in various compounds such triglycerides, flavonoids, and polyphenols, that can defend against damages induced by toxic drugs [32].…”

Section: Discussionsupporting

confidence: 81%

Protective Effect of Artemisia judaica against Doxorubicin-Induced Toxicity in Mice

Ahmed

Mabrouk

Hassanane

et al. 2017

ARRB

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Aim: The present study aimed to investigate the protective effect of Artemisia Judaica (A. Judaica) against doxorubicin (DOX)-induced toxicity in male mice. Place and Duration of Study: Department of Cell Biology, Genetic engineering and biotechnology division, National research centre, Egypt, between March 2016 and February 2017. Methodology: Male mice were divided into 7 groups (n=10) and treated as follow: the control group, the group treated with DMSO, the group injected (i.p.) with DOX , the groups treated with low and high dose of A. judaica extract and the groups injected (i.p.) with DOX and treated with low and high dose of A. judaica extract. Femur, testes and liver samples were collected for different analyses. Results: Our data showed that A. judaica significantly reversed the DOX-induced elevation of DNA fragmentation rate and MDA level in liver tissue, as well as declined chromosomal aberrations (CAs) either in the bone marrow cells or in the spermatocyte cells. Meanwhile, the expression of Ahmed et al.; ARRB, 18(3): 1-10, 2017; Article no.ARRB.35990 2 apoptosis-related genes (Bax and Caspase-3) in liver tissues was analyzed by quantitative real-time PCR (qRT-PCR) and results revealed that genes expression were up-regulated in DOX treated mice however; the administration of A. judaica didn't alter such increase. Conclusion: Overall, the findings indicated that A. judaica may attenuate the DOX-induced toxicity. However; further studies are required to confirm the protective effect of A. judaica extract against toxicity caused by DOX drug. Original Research Article

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Section: Discussionsupporting

confidence: 81%

Protective Effect of Artemisia judaica against Doxorubicin-Induced Toxicity in Mice

Ahmed

Mabrouk

Hassanane

et al. 2017

ARRB

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“…A recent study stated that DOX-treated group can increase both ALT and AST enzymes activity because of the liver damage and it is confirmed by the histological results (Barakat et al, 2018). The present results showed that DOX-treated group sections which stained with H&E showed focal hepatocyte necrosis and the hepatotoxicity that resulted are in accordance with Jambhulkar et al, (2014) and Mete et al, (2016) results which stated a parenchymal necrosis and proliferation of biliary ducts in DOXtreated group. Vacuolation of hepatocytes was reported as one of cellular defensive mechanism as they can collect the harmful elements and prevent their interfering with the biological functions of these cells and Pyknosis and karyolysis of the nuclei may be attributed to the loss of functional efficiency (AL-Mosaibih, 2013).…”

Section: Discussionsupporting

confidence: 90%

The probable protective Effect of Quercetin Against Doxorubicin-Induced Hepatotoxicity in Adult Albino Rats: A Biochemical and Immunohistopathological Study

Moustafa

Ali

2021

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Background: Doxorubicin (DOX) is an anthracycline antineoplastic which causes hepatotoxicity by induction of free radicals and inflammatory liver tissues. Quercetin (QCT) is considered as a potent antioxidant that may ameliorates hepatotoxicity. Aim of the work: The current study was designed to detect the toxic effects of DOX in liver cells and evaluating the possible protective role of QCT against those toxic alterations in adult male albino rats. Materials and methods: forty (40) male albino rates were divided to four groups: Control (group I), DOX-treated (group II): Rats received 18 mg/kg of body weight of DOX. Group III, received 60 ml/kg of QCT combined with DOX. Group IV treated with DOX plus 100 ml of QCT/kg. After scarification of rats, liver enzymes and the bile levels were estimated. The livers were extracted and used in oxidative stress markers, histological and immunological studies. Results: Doxorubicin administration induced an increase in liver enzymes, bile level and oxidative stress markers. QCT administration induced an improvement in those levels, especially with the high dose. The microscopic examinations of the DOX-treated sections showed loss of normal architectures of hepatic cells, enlargement and congestion of the central and portal veins and blood sinusoids, vacuolar degeneration, cholelithiasis and necrosis of H&E stained hepatocytes. PAS-stained liver sections in the DOX-treated group showed an increase in the depth of the stain. Quercetin administration improved these changes and hepatocytes which stained with PAS showed moderate to mild staining, especially with the high dose of QCT. Sections of the stained liver caspase-3, in DOX-treated group showed positive results with intensity. QCT treated groups showed little effects of caspase-3, especially with the high dose. Conclusion: Doxorubicin had toxic effects on rats' livers, with significant improvement after treatment with QCT as an antioxidant substance, and its high doses were more protective than low doses.

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“…Alpsoy et al ., recently showed that onion extracts have a protective effect on cadmium-induced oxidative stress [ 38 ]. Similarly, Mete et al ., reported that pretreatment with onion extract protects against doxorubicin-induced hepatotoxicity due to its antioxidant properties [ 39 ]. In addition, previous studies have shown that flavonoids afford cyto-protective effects against micronucleus induction in irradiated mice and lymphocytes [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Onion Extract on Bleomycin-Induced Cytotoxicity and Genotoxicity in Human Lymphocytes

Cho

Woo

Lee

et al. 2016

IJERPH

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Following one of the world's largest nuclear accidents, occured at Fukushima, Japan in 2011, a significant scientific effort has focused on minimizing the potential adverse health effects due to radiation exposure. The use of natural dietary antioxidants to reduce the risk of radiation-induced oxidative DNA damage is a simple strategy for minimizing radiation-related cancer rates and improving overall health. The onion is among the richest sources of dietary flavonoids and is an important food for increasing their overall intake. Therefore, we examined the effect of an onion extract on cyto-and geno-toxicity in human lymphocytes treated with bleomycin (BLM), a radiomimetic agent. In addition, we measured the frequency of micronuclei (MN) and DNA damage following treatment with BLM using a cytokinesis-blocked micronucleus assay and a single cell gel electrophoresis assay. We observed a significant increase in cell viability in lymphocytes treated with onion extract then exposed to BLM compared to cells treated with BLM alone. The frequency of BLM induced MN and DNA damage increased in a dose-dependent manner; however, when lymphocytes were pretreated with onion extract (10 and 20 µL/mL), the frequency of BLM-induced MN was decreased at all doses of BLM and DNA damage was decreased at 3 µg/mL of BLM. These results suggest that onion extract may have protective effects against BLM-induced cyto-and genotoxicity in human lymphocytes.

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Protective effects of onion (Allium cepa) extract against doxorubicin-induced hepatotoxicity in rats

Abstract: Our study indicates that pretreatment with ACE protects against DOX-induced hepatotoxicity due to the antioxidant properties of ACE. Further studies on efficacy of antioxidant treatment by ACE in DOX-mediated toxicity and underlying mechanisms would provide a better explanation.

Cited by 34 publications

References 28 publications

Protective Effect of Artemisia judaica against Doxorubicin-Induced Toxicity in Mice

Protective Effect of Artemisia judaica against Doxorubicin-Induced Toxicity in Mice

The probable protective Effect of Quercetin Against Doxorubicin-Induced Hepatotoxicity in Adult Albino Rats: A Biochemical and Immunohistopathological Study

Protective Effect of Onion Extract on Bleomycin-Induced Cytotoxicity and Genotoxicity in Human Lymphocytes

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