Protective effects of Modified Linggui Zhugan Decoction combined with short-term very low calorie diets on cardiovascular risk factors in obese patients with impaired glucose tolerance

Ke, Bin; Shi, Lin; Zhang, Junjie; Chen, Ding-sheng; Meng, Jian; Qin, Jian

doi:10.1016/s0254-6272(13)60010-2

Cited by 16 publications

(17 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, compared with that of HFD rats, the serum lipid profile was normalized by treatment as serum TC, TG, LDL and FFA levels were significantly decreased and the HDL levels were significantly elevated. These findings are in agreement with our previous work showing hypolipidemic effects of dietary restriction incorporated with MLD treatment in patients [ 18 , 19 ], which is largely due to increased fecal lipid excretion.…”

Section: Discussionsupporting

confidence: 93%

“…The treatment requires the participants to have less solid food, but drink millet soup. The MLD with the effects of warming and resolving the mucus, strengthening the spleen and removing the turbidity is simultaneously administered to restore normal function of the spleen in transportation and transformation [ 18 , 19 ]. Therefore, this study investigated effects of dietary restriction, dietary restriction incorporated with exercise, dietary restriction incorporated with exercise and MLD on high-fat diet-induced MS in rats.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modified lingguizhugan decoction incorporated with dietary restriction and exercise ameliorates hyperglycemia, hyperlipidemia and hypertension in a rat model of the metabolic syndrome

Yao

Wei

Shi

et al. 2017

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundModified Lingguizhugan Decoction (MLD) came from famous Chinese medicine Linggui Zhugan Decoction. The MLD is used for the treatment of metabolic syndrome in the clinical setting. Our study focuses on the comprehensive treatment of MLD incorporated with dietary restriction and exercise in a rat model of the metabolic syndrome (MS).MethodsRats were divided into five groups: control group (Cont), high-fat diet group (HFD), high-fat diet incorporated with dietary restriction group (HFD-DR), exercise incorporated with dietary restriction group (HFD-DR-Ex) and MLD incorporated with dietary restriction and exercise group (HFD-DR-Ex-MLD). Treatments were conducted for 1 week after feeding high-fat diet for 12 weeks. The effects of treatments on high fat diet-induced obesity, hyperglycemia, hyperlipidemia, hypertension, hepatic injury and insulin resistance in rats of MS were examined. In addition, the tumor necrosis factor-α (TNF-α), leptin and protein kinase B (PKB) in rats serum and liver were also examined by enzyme-linked immunosorbent assay (ELISA).ResultsAfter a week’s intervention by dietary restriction, dietary restriction incorporated with exercise or MLD, compared with HFD rats, the relative weight of liver and fat, levels of triglyceride, total cholesterol, low-density lipoprotein, free fatty acid, aspartate aminotransferase, glutamic-pyruvic transaminase and alkaline phosphatase, insulin, were significantly decreased (p < 0.05 or 0.01). This treatment also inhibited abnormal increases of TNF-α, leptin and PKB in serum and liver.ConclusionMLD incorporated with dietary restriction and exercise treatment exhibit effects in alleviating high-fat diet-induced obesity, hyperglycemia, hyperlipidemia, hypertension, hepatic injury and insulin resistance, which are possibly due to the down-regulation of TNF-α, leptin and PKB.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Modified lingguizhugan decoction incorporated with dietary restriction and exercise ameliorates hyperglycemia, hyperlipidemia and hypertension in a rat model of the metabolic syndrome

Yao

Wei

Shi

et al. 2017

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…The studies were performed in many different populations. Eleven studies [16–18, 20, 21, 23, 25, 28–30, 33] mentioned complications, including hypertension, impaired glucose tolerance, spleen hypofunction, excessive sweating, nonalcoholic fatty liver disease, hyperlipidemia, and metabolic syndrome. Of the 18 studies, 6 were completed by Chinese researchers, and the remaining 12 were from Japan, Australia, Canada, USA, Russia, France, Indonesia, Korea, Indian, Thailand, and Italy.…”

Section: Resultsmentioning

confidence: 99%

Herbal Medicine for the Treatment of Obesity: An Overview of Scientific Evidence from 2007 to 2017

Liu

Sun

Yao

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Obesity is a very common global health problem, and it is known to be linked to cardiovascular and cerebrovascular diseases. Western medical treatments for obesity have many drawbacks, including effects on monoamine neurotransmitters and the potential for drug abuse and dependency. The safety of these medications requires improvement. Herbal medicine has been used for treatment of disease for more than 2000 years, and it has proven efficacy. Many studies have confirmed that herbal medicine is effective in the treatment of obesity, but the mechanisms are not clear. This article will discuss the possible effects and mechanisms of herbal medicine treatments for obesity that have been reported in the past decade.

show abstract

“…In Gao et al's study [ 16 ], 4 cases in the TCM intervention group showed mild abdominal distension; 3 cases in the control group showed mild abdominal distension. In Ke et al's study [ 33 ], 5 patients in the treated group felt fatigue, hunger, and dizziness, which were recovered after giving normal diets. In Shi et al's study [ 36 ], 1 patient in the JLD group experienced diarrhea, and 1 subject in the control group had nausea.…”

Section: Resultsmentioning

confidence: 99%

Efficiency and Safety of Chinese Herbal Medicine in the Treatment of Prediabetes: A Systemic Review and Meta‐Analysis of Randomized Controlled Trials

Song

Wang

Qin

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. The aim of this study was to review existing evidence on the efficiency and safety of Chinese herbal medicine for the treatment of prediabetes. Methods. Randomized controlled trials (RCTs) of Chinese herbal medicine (CHM) to treat prediabetes were searched in the following databases from their inception date onwards until 2 May 2020: MEDLINE, Cochrane, EMBASE, Web of Science, EBSCO, CINAHL, CNKI, VIP database, CBM, and Wanfang database. Quality assessment of included trials was accessed according to the guidance in Cochrane. Researchers independently assessed the validity of included trials and extracted outcome data for synthesis. RevMan 5.3 was used for the meta-analysis. Results. Twenty-two RCTs including 3923 participants were included in the study. Our findings upon the 22 RCTs showed CHM is effective in the treatment of prediabetes, which can statistically reduce the incidence of diabetes (RR = 0.48; 95% CI = (0.41, 0.57); P < 0.001 ), increase the incidence of normalization of prediabetes (RR = 1.76; 95% CI = (1.57, 1.96); P < 0.001 ), and lower FPG (MD = −0.38; 95% CI = (−0.60, −0.16); P < 0.001 ), 2hPG (MD = −1.13; 95% CI = (−1.60, −0.67); P < 0.001 ), TG (MD = −0.23; 95% CI = (−0.33, −0.13); P < 0.001 ), TC (MD = −0.34; 95% CI = (−0.52, −0.16); P < 0.001 ), and BMI (MD = −0.48; 95% CI = (−0.78, −0.18); P < 0.001 ) after treatment, and there was no difference of HbA1c ( P > 0.05 ). Conclusion. CHM is effective for the treatment of prediabetes. CHM can statistically reduce the incidence of diabetes, increase the incidence of normalization of prediabetes, and lower the FPG, 2hPG, TG, TC, and BMI levels, but with no significant difference in HbA1c. In addition, CHM was relatively safe in clinical practice. More high-quality RCTs should be conducted to strengthen the finding.

show abstract

Protective effects of Modified Linggui Zhugan Decoction combined with short-term very low calorie diets on cardiovascular risk factors in obese patients with impaired glucose tolerance

Cited by 16 publications

References 15 publications

Modified lingguizhugan decoction incorporated with dietary restriction and exercise ameliorates hyperglycemia, hyperlipidemia and hypertension in a rat model of the metabolic syndrome

Modified lingguizhugan decoction incorporated with dietary restriction and exercise ameliorates hyperglycemia, hyperlipidemia and hypertension in a rat model of the metabolic syndrome

Herbal Medicine for the Treatment of Obesity: An Overview of Scientific Evidence from 2007 to 2017

Efficiency and Safety of Chinese Herbal Medicine in the Treatment of Prediabetes: A Systemic Review and Meta‐Analysis of Randomized Controlled Trials

Contact Info

Product

Resources

About