Protective effects of modafinil administration on testicular torsion/detorsion damage in rats

Yousefi‐Manesh, Hasan; Shirooie, Samira; Hemati, Sara; Shokrian-Zeini, Mohadeseh; Zarei, Nazanin; Raoufi, Mojtaba; Farrokhi, Vida; Dehpour, Ahmad Reza

doi:10.1016/j.yexmp.2019.104305

Cited by 32 publications

(27 citation statements)

References 21 publications

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“…A study has suggesting that modafinil significantly reduces MDA and NF-κB levels in animal models and exerts protective effects (Yousefi-Manesh et al 2019a, 2019b. The result was similar to the finding in our study.…”

Section: Discussionsupporting

confidence: 92%

“…After surgery, the rats were intraperitoneally administered with modafinil (10 mg/kg, Sigma-Aldrich, Merck KGaA, Germany) dissolved in dimethyl sulfoxide (50% DMSO) once daily for 3 days (AP+modafinil group). The dose of modafinil could exert protective roles partly through reducing inflammation (Yousefi-Manesh et al 2019b). In addition, the preliminary study showed that the dose of modafinil could ameliorate pancreatic injury.…”

Section: Animalsmentioning

confidence: 95%

“…In addition to these indications, modafinil is also widely used in other diseases. Animal studies have shown that modafinil can inhibit inflammation via decreasing pro-inflammatory factors and increasing anti-inflammatory factors (Han et al 2018;Yousefi-Manesh et al 2019b). In addition, it affects oxidative stress partly by decreasing malondialdehyde (MDA), one of products of membrane lipid peroxidation (Yousefi-Manesh et al 2019b).…”

Section: Introductionmentioning

confidence: 99%

“…Animal studies have shown that modafinil can inhibit inflammation via decreasing pro-inflammatory factors and increasing anti-inflammatory factors (Han et al 2018;Yousefi-Manesh et al 2019b). In addition, it affects oxidative stress partly by decreasing malondialdehyde (MDA), one of products of membrane lipid peroxidation (Yousefi-Manesh et al 2019b). And modafinil regulates Akt/NF-κB pathway to ameliorate inflammation in atherosclerosis mouse with apoE deficiency (Han et al 2018).…”

Section: Introductionmentioning

confidence: 99%

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Modafinil ameliorated pancreatic injury and inflammation through upregulating SNIP1

Qin

et al. 2020

gpb

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Acute pancreatitis (AP) is the inflammatory response of the exocrine pancreas to various causes. Modafinil has significant anti-inflammation and anti-oxidation effects. No experiment has assessed the effects of modafinil on AP. Thus, the study aims to study the effects of modafinil on AP and its potential mechanism in vivo and vitro. 5% sodium taurocholate was retrograde injected into pancreatic duct to establish AP rat model. The severity of AP was detected by H&E staining, serum amylase and lipase levels. The inflammation, oxidative stress and apoptosis were detected separately by ELISA, MDA and SOD kits, tunnel staining and Western blotting in rats. Besides, SNIP1 expression was analyzed by qPCR and Western blotting. In vivo, AR42J cells were stimulated by cerulein and lipopolysaccharide to establish AP cell model. Flow cytometry examined cell apoptosis. After the plasmids silencing SNIP1 were transfected into AP cells, the inhibitory effects of modafinil on inflammation, oxidative stress and apoptosis were significantly reversed. The results indicated that modafinil showed significant curative and therapeutic effects by regulating SNIP1 levels.

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Section: Discussionsupporting

confidence: 92%

Section: Animalsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Modafinil ameliorated pancreatic injury and inflammation through upregulating SNIP1

Qin

et al. 2020

gpb

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“…In fact, ROS, which occurs after the reperfusion event, induces the inflammatory response (Shimizu et al., 2016). Similar to our study, TNF‐α levels in torsion/detorsion groups increased in previous studies (Refaie, 2018; Yousefi‐Manesh et al., 2019). The increase in TNF‐α levels in T‐2h/D‐2h group and T‐2h/D‐24h group indicates that the torsion/detorsion event causes an inflammatory reaction (Kandemir et al., 2017).…”

Section: Discussionsupporting

confidence: 92%

Investigation of the protective role of chrysin within the framework of oxidative and inflammatory markers in experimental testicular ischaemia/reperfusion injury in rats

Belhan

Yıldırım

Karasu³

et al. 2020

Andrologia

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After the rotation of the spermatic cord structures around their own axes, testicular torsion occurs due to the deterioration of blood flow in the testicle (Ramachandra, Palazzi, Holmes, & Marietti, 2015). Although it can be seen at any age, it is mostly seen in childhood and puberty (Barada, Weingarten, & Cromie, 1989). Trauma, excessive exercise and contraction of the cremaster muscle may cause torsion in the testes (Shukla, Kelly, Daly, & Guiney, 1982). The ischaemic condition, which is shaped by the duration of torsion, causes necrosis in germinal cells and can even result in infertility (Gezici, Ozturk, Buyukbayram, Ozturk, & Okur, 2006; Wei, Yan, & Zhou, 2011). To prevent this, the achievement of reperfusion by detorsion (to ensure blood flow to the testis) must be done without delay, as delay can cause permanent damage to occur. However, reperfusion causes some complications, even if it shows a healing effect in ischaemic tissue (Akgür, Kilinc, Tanyel, Büyükpamukcu, & Hicsonmez, 1994). Reactive oxygen radicals introduced into the environment after reperfusion lead to lipid peroxidation in cells. This disrupts the permeability of the membrane and leads to loss of cell viability (Sikka, 2004). Many antioxidant agents, such as melatonin, resveratrol, allopurinol, N-acetylcysteine, caffeic acid and coenzyme Q10, have been used with different success rates to minimise the effects of oxidative stress in testicular torsion (Karaguzel, Kadihasanoglu, & Kutlu, 2014). Chrysin, the main component of the herbal medicine known

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Modafinil lightens apoptosis and inflammatory response in hepatic ischemia‐reperfusion injury through inactivation of TLR9/Myd88/p38 signaling

Zhang,

Wang

2024

Drug Development Research

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Hepatic ischemia/reperfusion injury (IRI) remains a severe threat during liver surgery and transplantation, accounting for unfavorable clinical outcomes. Modafinil (MOD), a wakefulness‐inducing compound, is increasingly disclosed to protect against IRI. However, the specific literatures covering the association between MOD and hepatic IRI are few. Here, this paper is committed to unraveling the role and response mechanism of MOD in hepatic IRI. After the establishment of hepatic IRI mice model and cell model, relevant assay kits measured the concentrations of biochemical indicators of hepatotoxicity and hematoxylin and eosin staining estimated liver morphology. Enzyme‐linked immunosorbent assay, reverse‐transcription quantitative polymerase chain reaction, and western blot evaluated inflammatory levels. Terminal‐deoxynucleoitidyl transferase‐mediated nick end labeling assay and western blot appraised apoptosis. Western blot also analyzed the expression of Toll‐like receptor 9 (TLR9)/myeloid differentiation primary response gene 88 (MyD88)/p38 signaling‐associated proteins. Cell counting kit‐8 method judged cell viability. MOD was discovered to mitigate liver dysfunction and morphological damage, inflammatory response, apoptosis in vivo and improve cell viability, suppress inflammatory response and apoptosis in vitro. In addition, MOD inactivated TLR9/Myd88/p38 signaling both in vitro and in vivo. Further, TLR9 elevation reversed the inhibitory role of MOD in inflammatory response and cell apoptosis in vitro. Anyway, MOD blocked TLR9/Myd88/p38 signaling to exhibit anti‐inflammatory and anti‐apoptotic properties in hepatic IRI.

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Protective effects of modafinil administration on testicular torsion/detorsion damage in rats

Cited by 32 publications

References 21 publications

Modafinil ameliorated pancreatic injury and inflammation through upregulating SNIP1

Modafinil ameliorated pancreatic injury and inflammation through upregulating SNIP1

Investigation of the protective role of chrysin within the framework of oxidative and inflammatory markers in experimental testicular ischaemia/reperfusion injury in rats

Modafinil lightens apoptosis and inflammatory response in hepatic ischemia‐reperfusion injury through inactivation of TLR9/Myd88/p38 signaling

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