Protective effects of lithium: A new look at an old drug with potential antioxidative and anti-inflammatory effects in an animal model of sepsis

Albayrak, Abdulmecit; Halıcı, Zekai; Polat, Beyzagül; Karakuş, Emre; Çadırcı, Elif; Bayır, Yasin; Kunak, Semih C.; Karcioglu, Saliha Sena; Yığıt, Serbülent; Ünal, Deniz; Atamanalp, Sabri Selçuk

doi:10.1016/j.intimp.2013.03.018

Cited by 60 publications

(46 citation statements)

References 55 publications

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“…Chronic lithium treatment normalised catalase (CAT) and superoxide dismutase activity in the rat model of depression (51) and decreased TBARs formation (52,53) or increased CAT activity (54) in an animal model of mania. Moreover, similar results of OxS parameters under lithium treatment were shown in an animal model of sepsis (55).…”

Section: Lipid Peroxidationsupporting

confidence: 74%

Impact of lithium alone or in combination with haloperidol on oxidative stress parameters and cell viability in SH-SY5Y cell culture

Gawlik-Kotelnicka

Mielicki

Rabe‐Jabłońska

et al. 2015

Acta Neuropsychiatr.

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Section: Lipid Peroxidationsupporting

confidence: 74%

Impact of lithium alone or in combination with haloperidol on oxidative stress parameters and cell viability in SH-SY5Y cell culture

Gawlik-Kotelnicka

Mielicki

Rabe‐Jabłońska

et al. 2015

Acta Neuropsychiatr.

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“…When the inflammatory process is involved, macrophages, which are released due to inflammation, induce organ damage by releasing pro-inflammatory cytokines and oxidants (Albayrak et al, 2013b). In pathologic situations, such as nephrotoxicity, in which oxidative stress is elevated, an imbalance occurs between oxidants and antioxidants due to organ damage (Cadirci et al, 2011;Gu et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Tnf-α inhibition by infliximab as a new target for the prevention of glycerol-contrast-induced nephropathy

Sarıtemur

Çadırcı

et al. 2015

Environmental Toxicology and Pharmacology

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“…The beneficial effects of propofol administration on the inflammation of lungs after intravenous endotoxin administration has been shown in rats [42][43][44][45][46][47][48][49][50].…”

Section: New Approachesmentioning

confidence: 99%

Sepsis and Septic Shock: Current Treatment Strategies and New Approaches

et al. 2017

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Sepsis is a complex condition characterized by the simultaneous activation of inflammation and coagulation in response to microbial insult. These events manifest as systemic inflammatory response syndrome or sepsis symptoms through the release of proinflammatory cytokines, procoagulants, and adhesion molecules from immune cells and/or damaged endothelium. Today, sepsis is a severe multisystem disease with difficult treatments for its manifestations and high mortality rates. In the last two decades in particular, many studies have been conducted on sepsis that cause shock, multiorgan dysfunction, and organ failure by especially leading to hemodynamic changes. In sepsis, increasing antibiotic resistance and medicine-resistant hemodynamic changes have resulted in further research on new treatment modalities in addition to classical treatments. In the last decade, the sepsis physiopathology has been elucidated. Various therapeutic agents have been used in addition to antibiotherapy, but no satisfactory results have been obtained. This review summarizes the sepsis pathophysiology, current treatment protocols, and new approaches.

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Protective effects of lithium: A new look at an old drug with potential antioxidative and anti-inflammatory effects in an animal model of sepsis

Cited by 60 publications

References 55 publications

Impact of lithium alone or in combination with haloperidol on oxidative stress parameters and cell viability in SH-SY5Y cell culture

Impact of lithium alone or in combination with haloperidol on oxidative stress parameters and cell viability in SH-SY5Y cell culture

Tnf-α inhibition by infliximab as a new target for the prevention of glycerol-contrast-induced nephropathy

Sepsis and Septic Shock: Current Treatment Strategies and New Approaches

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