Protective Effects Of Ibuprofen And L-carnitine Against Whole Body Gamma Irradiation-induced Duodenal Mucosal Injury

Akpolat, Meryem; Tarladacalisir, Yeter Topcu; Dökmeci, Dikmen; Turan, Fatma Nesrin; Uzal, Mustafa Cem

doi:10.5174/tutfd.2009.02685.2

Cited by 3 publications

(2 citation statements)

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“…Evidence indicated that dietary l -carnitine is beneficial to sows, by enhancing reproduction performance and milk production ( 8 – 10 ) . Furthermore, other studies have demonstrated that l -carnitine supplementation may enhance gastrointestinal protective ( 11 , 12 ) , antioxidant ( 13 ) , anti-inflammatory ( 14 ) and radioprotective ( 15 ) properties.…”

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confidence: 99%

Effects ofl-carnitine and/or maize distillers dried grains with solubles in diets of gestating and lactating sows on the intestinal barrier functions of their offspring

et al. 2016

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The objective of this study was to investigate the effects of L-carnitine and/or maize distillers dried grains with solubles (DDGS) in diets of gestating and lactating sows on the intestinal barrier functions of their offspring. The experiment was designed as a 2 × 2 factorial with two dietary treatments (soyabean meal v. DDGS) and two L-carnitine levels (0 v. 100 mg/kg in gestating diets and 0 v. 200 mg/kg in lactating diets). Sows (Landrace × Large White) with an average parity of 4·2 with similar body weight were randomly assigned to four groups of thirty each. Dietary supplementation with L-carnitine increased the total superoxide dismutase activity but decreased the concentration of malondialdehyde of the jejunal mucosa in newborn piglets and weaning piglets on day 21. Dietary supplementation with L-carnitine decreased the concentrations of IL-1β, IL-12 and TNF-α in the jejunal mucosa of newborn piglets and decreased the concentrations of IL-6 and TNF-α in the jejunal mucosa of weaning piglets on day 21. There was an interaction between dietary treatment and L-carnitine on the bacterial numbers of total eubacteria in the digesta of caecum in weaning piglets on day 21. Bacterial numbers of total eubacteria in weaning piglets on day 21 were significantly increased by L-carnitine only in soyabean meal diet, but there was no significant effect of L-carnitine in DDGS-based diet. Dietary supplementation with L-carnitine increased the bacterial numbers of Lactobacillus spp. and bifidobacteria spp. in the digesta of caecum in weaning piglets on day 21. Dietary supplementation with L-carnitine in sows affected the expression of tight junction proteins (claudin 1, zonula occludens-1 (ZO-1) and occludin) in the jejunal mucosa of their offspring by increasing the expression of ZO-1 mRNA in the jejunal mucosa of newborn piglets, and by increasing the expression of ZO-1 and occludin mRNA in the jejunal mucosa of weaning piglets on day 21. In conclusion, dietary supplementation with L-carnitine in gestating and lactating sows had positive effects on intestinal barrier functions of newborn piglets and weaning piglets on day 21, but it did not have effects on intestinal barrier functions of growing-finishing pigs in the filial generation. There were no effects of dietary treatment of sows on intestinal barrier functions in their offspring.

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confidence: 99%

Effects ofl-carnitine and/or maize distillers dried grains with solubles in diets of gestating and lactating sows on the intestinal barrier functions of their offspring

et al. 2016

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“…Intestine; histopathological examination showed less mucosal ulceration, submucosal edema and inflammatory cell infiltrate in irradiated rat treated with LC alone versus LC and VE for 5 consecutive days prior to irradiation (6 Gy), this results in agreement with (Caloglu, et al) (13) ; who reported that radiation-promote degenerative damage was definitely higher in the RT group, a radio protective effect of amifostine against all histopathological changes in small intestinal tissue was concluded; however LC has limited radio protective effects regarding vascular damage post radiation exposure. Also Akpolate and his colleagues (14) reported that ibuprofen and L-carnitine after oral administration had a protective effect by decreasing the severity of radiotherapy-induced duodenal mucosal injury in histopathological evaluation. L-carnitine significantly reduced the radiation induced histopathological damage caused to the colonic mucosa in rats and had a preventive effect on radiation colitis as reported by (Tas et al) (15) .…”

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confidence: 97%

Protective effect of L-carnitine and vitamin E on gastrointestinal tract organs on male rats post radiation exposure

Fouly

Ali

2021

Int J Radiat Res

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Background:Although ionizing radiation is a risk factor, it is a therapeutic agent for cancer. Objectives: The protective and defensive effect of L-Carnitine and vitamin E on gastrointestinal tract organs (liver, spleen and intestine) post whole body gamma irradiation exposure. Material and methods: 56 male albino rats, which were divided into four groups (14 rats per group); group (I): Control group, group (II): rats were irradiated with a single dose of whole body gamma rays (6 Gy) and left 4 weeks. Group (III): rats were given L-Carnitine for five days, then irradiated by same dose. Group (IV): rats were received L-Carnitine and vitamin E for five days then irradiated by same dose. At 1 and 4 weeks post radiation exposure, seven rats from each group were scarified, blood and GIT tissue samples were collected. Results: Liver and blood samples: radiation related degenerative damage was obviously higher in the radiation group than the control group with elevated liver enzymes, however pretreatment groups revealed reduced radiation induced acute liver damage compared to the radiation group with significant improvement in liver enzymes. Spleen and intestinal samples: radiation induced damage were significantly higher in the radiation group versus the control group, however, in pre-treatment groups no significant improvement in radiation induced effects were noted compared with radiation group. Conclusion: A great radio protective effect of both L-carnitine and vitamin E after radiation exposure mainly in liver tissue and its enzymes but not in both spleen and intestinal tissue.

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The Protective Effect of Curcumin on Ionizing Radiation-induced Cataractogenesis in Rats

Özgen¹,

Dökmeci²,

Akpolat³

et al. 2012

Balkan Med J

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Protective Effects Of Ibuprofen And L-carnitine Against Whole Body Gamma Irradiation-induced Duodenal Mucosal Injury

Cited by 3 publications

References 24 publications

Effects ofl-carnitine and/or maize distillers dried grains with solubles in diets of gestating and lactating sows on the intestinal barrier functions of their offspring

Effects ofl-carnitine and/or maize distillers dried grains with solubles in diets of gestating and lactating sows on the intestinal barrier functions of their offspring

Protective effect of L-carnitine and vitamin E on gastrointestinal tract organs on male rats post radiation exposure

The Protective Effect of Curcumin on Ionizing Radiation-induced Cataractogenesis in Rats

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