Protective effects of hydroalcoholic extracts from an ancient apple variety ‘Mela Rosa dei Monti Sibillini’ against renal ischemia/reperfusion injury in rats

Yousefi‐Manesh, Hasan; Hemmati, Sara; Shirooie, Samira; Nabavi, Seyed Mohammad; Bonakdar, Azita Talebzadeh; Fayaznia, Reza; Asgardoon, Mohammad Hossein; Dehnavi, Ali Zare; Ghafouri, Mohammad; Wandjou, Joice Guileine Nkuimi; Caprioli, Giovanni; Sut, Stefania; Maggi, Filippo; Dall’Acqua, Stefano

doi:10.1039/c9fo01635j

Cited by 8 publications

(18 citation statements)

References 30 publications

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“…In the present study, CCl4 administration increased the serum levels of ALT, AST, ALP. Yousefi-Manesh et al have reported that APE prevented kidney injury induced by ischemia and reduced oxidative stress [8]. In the present study, the pretreatment of rats with both APE and APP obtained from the same Italian apple variety (Mela Rosa dei Monti Sibillini) significantly reduced the serum levels of ALT, AST and ALP compared to the CCl4 group suggesting a protective effect.…”

Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

“…Extracts enriched in phytoconstituents may also exert significant effects in some disease models and we previously observed significant protective effects of extracts from the Mela Rosa dei Monti Sibillini against renal ischemia/reperfusion injury in rats [8].…”

Section: Introductionmentioning

confidence: 92%

“…HPLC-DAD-MS n was used to analyze the phenolic derivatives of the extracts. The analytical methods are the ones used in our previous works [1,8].…”

Section: Hplc-dad-ms N Analysismentioning

confidence: 99%

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Hepatoprotective Effects of Standardized Extracts from an Ancient Italian Apple Variety (Mela Rosa dei Monti Sibillini) against Carbon Tetrachloride (CCl4)-Induced Hepatotoxicity in Rats

et al. 2020

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The aim of this research was to examine the effect of the hydroalcoholic extracts from the peel (APE) and pulp (APP) of a traditional apple cultivar from central Italy (Mela Rosa dei Monti Sibillini) on CCl4-induced hepatotoxicity in rats. Phytoconstituents were determined by liquid chromatography–mass spectrometry (LC-MS) analysis showing an abundance of proanthocyanidins and flavonol derivatives together with the presence of annurcoic acid in APE. Wistar rats received APE/APP (30 mg/kg oral administration) for three days before CCl4 injection (2 mL/kg intraperitoneal once on the third day). Treatment with both APE and APP prior to CCl4 injection significantly decreased the serum levels of aspartate aminotransferase (AST), alkaline phosphatase (ALP) and alanine aminotransferase (ALT) compared to the CCl4 group. Besides, pretreatment with APE reversed the CCl4 effects on superoxide dismutase (SOD), myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α) and interleukin-1beta (IL-1β) levels in liver tissue in rats and reduced tissue damage as shown in hematoxylin and eosin staining. These results showed that this ancient Italian apple is worthy of use in nutraceuticals and dietary supplements to prevent and/or protect against liver disorders.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

“…HPLC-DAD-MS n was used to analyze the phenolic derivatives of the extracts. The analytical methods are the ones used in our previous works [1,8].…”

Section: Hplc-dad-ms N Analysismentioning

confidence: 99%

See 2 more Smart Citations

Hepatoprotective Effects of Standardized Extracts from an Ancient Italian Apple Variety (Mela Rosa dei Monti Sibillini) against Carbon Tetrachloride (CCl4)-Induced Hepatotoxicity in Rats

et al. 2020

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“…Annurcoic acid is a more bioavailable form of ursolic acid, given its chemical resemblance and the presence of an additional hydroxylic group. Ursolic acid is an important inhibitor of the NF-kB-mediated inflammatory response [21].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Enzyme Inhibitory Properties of the Polyphenolic-Rich Extract from an Ancient Apple Variety of Central Italy (Mela Rosa dei Monti Sibillini)

Wandjou

Mevi

Sagratini

et al. 2019

Plants

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This study was undertaken to evaluate the nutraceutical potential of the Mela Rosa dei Monti Sibillini (MR), an ancient apple variety of the Sibillini Mountains, central Italy. The chemical profile of the apple’s polyphenolic-rich extract (MRE) obtained from first- and second-choice samples using the Amberlite® XAD7HP resin was analyzed by High Performance Liquid Chromatography with Diode-Array and Mass spectrometry (HPLC-DAD-MS) and 21 phytochemicals were quali–quantitatively determined. For comparative purposes, the polyphenol-rich extract of Annurca (ANE), a southern Italian variety, was analyzed. The antioxidant capacity of MREs was evaluated by Folin–Ciocalteu, 1, 1-diphenyl-2-picrylhydrazyl (DPPH), and 2, 2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays. The inhibitory capacity of MREs for the enzymes α-glucosidase, lipase, monoamine oxidase A, tyrosinase, and acetylcholinesterase was also determined. The MREs showed higher polyphenolic and triterpene profiles than the ANE. Their radical scavenging activity was higher than that of ANE and comparable to the reference trolox. The MRE from the second-choice apples displayed higher contents of the 21 phytochemicals investigated. Either MRE from second-choice or first-choice samples showed enzymatic inhibition with IC50 values higher than those of reference inhibitors but worthy of nutraceutical consideration. Taken together, these results show the potential of MRE as a source of bioactive compounds to be used for pharmaceutical, nutraceutical, and cosmeceutical applications has been confirmed.

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Typical plant-based food from a nutraceutical perspective: The case of the Marche region

Sagratini

Santini²,

Caprioli³

et al. 2023

Case Studies on the Business of Nutraceuticals, Functional and Super Foods

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Protective effects of hydroalcoholic extracts from an ancient apple variety ‘Mela Rosa dei Monti Sibillini’ against renal ischemia/reperfusion injury in rats

Abstract: The purpose of this work was to investigate the effect of hydroalcoholic extracts from the peel and pulp of a traditional apple variety of central Italy on the damage caused by renal ischemia/reperfusion injury in rats.

Cited by 8 publications

References 30 publications

Hepatoprotective Effects of Standardized Extracts from an Ancient Italian Apple Variety (Mela Rosa dei Monti Sibillini) against Carbon Tetrachloride (CCl4)-Induced Hepatotoxicity in Rats

Hepatoprotective Effects of Standardized Extracts from an Ancient Italian Apple Variety (Mela Rosa dei Monti Sibillini) against Carbon Tetrachloride (CCl4)-Induced Hepatotoxicity in Rats

Antioxidant and Enzyme Inhibitory Properties of the Polyphenolic-Rich Extract from an Ancient Apple Variety of Central Italy (Mela Rosa dei Monti Sibillini)

Typical plant-based food from a nutraceutical perspective: The case of the Marche region

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