Protective effects of ethyl pyruvate in cisplatin-induced nephrotoxicity

Kelle, İlker; Akkoç, Hasan; Tunik, Selcuk; Nergız, Yusuf; Erdinç, Meral; Erdinç, Levent

doi:10.1080/13102818.2014.942489

Cited by 13 publications

(9 citation statements)

References 48 publications

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“…Likewise, rather than individually determining antioxidant molecules, we measured TAS, according to the techniques of Erel, as well [ 35 ]. In previous studies, it was suggested that OSI could show the oxidative state more precisely than the sole levels of TOS or TAS [ 40 , 41 ]. Hence, OSI could be regarded as an approximate indicator for identifying Cis-mediated genotoxicity, hepatotoxicity, nephrotoxicity, and preservation provided by NOX in subjects under Cis treatment.…”

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Naringenin-Oxime on Cisplatin-Induced Toxicity in Rats

Koyuncu

Koçyiğit

Gönel

et al. 2017

Biochemistry Research International

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The aim of this study is to examine the protective effect of naringenin-oxime (NOX) on cisplatin-induced major organ toxicity and DNA damage in rats. Thirty-five male Wistar albino rats were equally split into five groups as follows: control (i.p., 0.1 ml of saline), Cis administration (i.p., 7 mg/kg b.w.), NOX treatment (i.p., 20 mg/kg b.w., daily for ten days), Cis + NOX20, and Cis + NOX40 combination (i.p., 20 and 40 mg/kg b.w., daily for ten days). Serum and peripheral blood mononuclear leukocytes (PBMC) were obtained from blood. Malondialdehyde, glutathione, total antioxidant and oxidant status, and catalase were measured in serum, liver, and kidney, and oxidative stress index was calculated. In parallel, paraoxonase and arylesterase activities were tested in liver and serum. We used 8-OHdOG as a marker for DNA damage in serum via ELISA and in PMBC via comet assay. Treatment with Cis elevated the levels of serum biochemical parameters, oxidative stress, and DNA damage. Pretreatments of NOX restored biochemical and oxidative stress parameters in serum, renal, and liver tissues (p < 0.01) and reduced 8-OHdG level, a finding further supported by comet assay in PBMC. Observations of the present study support the fact that treatment with NOX prevents Cis-induced hepatotoxicity, nephrotoxicity, and genotoxicity by restoring antioxidant system.

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Section: Discussionmentioning

confidence: 99%

The Protective Effect of Naringenin-Oxime on Cisplatin-Induced Toxicity in Rats

Koyuncu

Koçyiğit

Gönel

et al. 2017

Biochemistry Research International

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“…Moreover, although a direct comparison of EP efficacy compared to other HMGB1 inhibitors is currently lacking, EP has been safely tested in humans and has been used in clinical trials [ 43 ]. In addition, some preclinical studies have demonstrated that inhibition of HMGB1 release by EP significantly increased the tumor cell sensitivity to other anticancer agents [ 17 ], and also protected against chemotherapy-induced cytotoxicity [ 45 ]. In summary, this evidence supports the possible use of EP as an adjuvant in MM treatment.…”

Section: Discussionmentioning

confidence: 99%

HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma

et al. 2017

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Human malignant mesothelioma (MM) is an aggressive cancer linked to asbestos and erionite exposure. We previously reported that High-Mobility Group Box-1 protein (HMGB1), a prototypic damage-associated molecular pattern, drives MM development and sustains MM progression. Moreover, we demonstrated that targeting HMGB1 inhibited MM cell growth and motility in vitro, reduced tumor growth in vivo, and prolonged survival of MM-bearing mice. Ethyl pyruvate (EP), the ethyl ester of pyruvic acid, has been shown to be an effective HMGB1 inhibitor in inflammation-related diseases and several cancers. Here, we studied the effect of EP on the malignant phenotype of MM cells in tissue culture and on tumor growth in vivo using an orthotopic MM xenograft model. We found that EP impairs HMGB1 secretion by MM cells leading to reduced RAGE expression and NF-κB activation. As a consequence, EP impaired cell motility, cell proliferation, and anchorage-independent growth of MM cells. Moreover, EP reduced HMGB1 serum levels in mice and inhibited the growth of MM xenografts.Our results indicate that EP effectively hampers the malignant phenotype of MM, offering a novel potential therapeutic approach to patients afflicted with this dismal disease.

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“…21,22,35 Previous studies have suggested that OSI may be a more accurate indicator of oxidative status than single TOS or TAS levels. 36,37 Various chemotherapy agents, such as cisplatin in particular, by leading to excessive oxidant production in the body or weakening of the antioxidant mechanism, have been shown to cause an increase in TOS and OSI and a decrease in TAS. 38 In addition, these parameters have been used as an oxidative stress parameter in various inflammatory skin diseases such as psoriasis and dermatitis.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of adenosine triphosphate against sunitinib-related skin damage in rats

et al. 2020

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Cutaneous side effects associated with sunitinib use are a major problem in patients receiving cancer treatment. The aim of this study was to investigate the protective effect of adenosine triphosphate (ATP) against possible skin damage resulting from sunitinib use in rats. Thirty Albino Winstar rats were divided into the following three groups: healthy controls (HCs, n = 10), sunitinib (SUN, n = 10), and sunitinib + ATP (SAT, n = 10). ATP was injected intraperitoneally at a dose of 2 mg/kg. One hour subsequent to the administration of ATP and 0.9% NaCl, the SAT and SUN groups were orally administered a dose of 25 mg/kg sunitinib to the stomach. Macroscopic evaluation of the skin indicated lower levels of skin damage in the SAT group than in the SUN group. As an indicator of oxidative stress, malondialdehyde (MDA), total oxidant status (TOS), and oxidative stress index (OSI) levels were significantly higher in the SUN group than in the HC group, while total glutathione (tGSH) and total antioxidant status (TAS) levels were significantly lower. However, MDA, TOS, and OSI levels were significantly lower in the SAT group than in the SUN group, while tGSH and TAS levels were significantly higher. Histopathological examination revealed keratin plugs with edema, vasopathology, and inflammatory cell infiltration in the SUN group. The SAT group showed less necrotic epithelium, keratin plugs, edema, and vasopathology than the SUN group. ATP can be effective in preventing skin damage caused by sunitinib use by reducing oxidative stress.

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Protective effects of ethyl pyruvate in cisplatin-induced nephrotoxicity

Cited by 13 publications

References 48 publications

The Protective Effect of Naringenin-Oxime on Cisplatin-Induced Toxicity in Rats

The Protective Effect of Naringenin-Oxime on Cisplatin-Induced Toxicity in Rats

HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma

Protective effect of adenosine triphosphate against sunitinib-related skin damage in rats

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