volume 73, issue 4, P522-534 2021
DOI: 10.1093/jpp/rgaa003
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Glory Florence Meejuru, Anushri Somavarapu, Ravi Chandra Sekhara Reddy Danduga, Lakshmi Sudeepthi Nissankara Roa, Phani Kumar Kola

Abstract: Abstract Objectives This study aimed to evaluate the effect of duloxetine (10 and 20 mg/kg) against chronic immobilisation stress (CIS)-induced anxiety, depression, cognitive impairment and neurodegeneration in mice. Methods CIS, 2 h/10 days (11:00 AM–1:00 PM) was applied after 30 min of pretreatment with saline, duloxetine 10 mg/kg and 20 mg/kg to the respective groups of animals, except the…

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