2017
DOI: 10.5505/tjtes.2016.49103
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Abstract: BACKGROUND:The aim of this study was to evaluate the effects of remote ischemic preconditioning (RIPC) and dexmedetomidine as pharmacological conditioning in a rat renal ischemia/reperfusion (IR) injury model.

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Cited by 6 publications
(7 citation statements)
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“…Preclinical studies have widely reported the renoprotective effects of DEX following renal ischemia-reperfusion [18,[35][36][37][38]. In the context of LT, both Yu et al and Yao et al have demonstrated that pre-treatment with DEX reduces AKI following orthotopic autologous LT in rats by suppressing TLR4/NF-κB pathway activation [22] and by enhancing antioxidant levels through activation of nuclear factor erythroid 2-related factor 2 [23].…”
Section: Effects Of Dexmedetomidine On Dysfunction Of Other Organs Fomentioning
confidence: 99%
“…Preclinical studies have widely reported the renoprotective effects of DEX following renal ischemia-reperfusion [18,[35][36][37][38]. In the context of LT, both Yu et al and Yao et al have demonstrated that pre-treatment with DEX reduces AKI following orthotopic autologous LT in rats by suppressing TLR4/NF-κB pathway activation [22] and by enhancing antioxidant levels through activation of nuclear factor erythroid 2-related factor 2 [23].…”
Section: Effects Of Dexmedetomidine On Dysfunction Of Other Organs Fomentioning
confidence: 99%
“…Therefore, we may assume that 1 min closure of the kidney vessels may not be adapted for the whole kidney against major RIR. Accordingly, a longer ischemia time is suggested to have an efficient IPC (3, 20, 23).…”
Section: Discussionmentioning
confidence: 99%
“… 5 , 6 Many studies have reported that continuous infusion of dexmedetomidine reduces renal IR injury in patients and rats. 7 , 8 …”
Section: Introductionmentioning
confidence: 99%
“…5,6 Many studies have reported that continuous infusion of dexmedetomidine reduces renal IR injury in patients and rats. 7,8 This study, in rats with spinal cord IR injury, aimed to contribute to the literature by assuming that dexmedetomidine, which is applied through different routes of administration in kidney tissue, may have a protective effect.…”
Section: Introductionmentioning
confidence: 99%