Protective effects of astaxanthin on a combination of D-galactose and jet lag-induced aging model in mice

Abstract

Oxidative stress caused free radical and mitochondrial damage plays a critical role in the progression of aging and age-related damage at the cellular and tissue levels. Antioxidant supplementation has received growing attention and the effects of antioxidant on aging are increasingly assessed in both animal and human studies. However, additional and more promising treatments that contribute to the expansion of anti-aging therapies are needed. Astaxanthin, a super antioxidant carotenoid and free radical scavenger, inhibits lipid peroxidation more potently than vitamin E. In the present study, we investigated the preventative effects of astaxanthin on aging using an accelerated aging model: mice chronically treated with a combination of D-galactose and jet lag. After 6 weeks of treatment, astaxanthin administration tended to protect the liver weight loss in aged mice. It is probably by upregulating the mRNA expression of galactose-1-phosphate uridyltransferase, which contribute to the enhancement of D-galactose metabolism. Astaxanthin supplementation also improved muscle endurance of aged mice in a swimming test. These results were associated with reduced oxidative stress in serum and increased anti-oxidative enzymes activities and mRNA expression in vivo. Moreover, astaxanthin reversed the dysregulation of aging-related gene expression caused by the combination of D-galactose and jet lag in the liver and kidney of mice. In conclusion, astaxanthin prevents liver weight loss, ameliorates locomotive muscular function, exerts significant anti-aging effects by reducing oxidative stress and improving the expression of age-related genes in D-galactose and jet lag-induced aging model.

Lactobacillus and Bifidobacterium Improves Physiological Function and Cognitive Ability in Aged Mice by the Regulation of Gut Microbiota

“…Studies have found that cumulative oxidative stress and low grade inflammation exist during the normal aging process . Consistent with our pervious study, the mRNA expressions of anti‐oxidant enzyme also decreased in peripheral tissues in the current study (Figure ). Recently, probiotics are found to be effective in reducing oxidative damage, increasing free radical scavenging rate, and modifying anti‐oxidative enzymes activity in human cells .…”

“…The cDNA was synthesized using a reverse transcriptase kit (Toyobo, Osaka, Japan) according to the manufacturer's instructions. Real‐time quantitative PCR was performed using SYBR Green Realtime PCR Master Mix (Toyobo, Osaka, Japan) in an Eppendorf MasterCyclerep RealPlex2 System (Wesseling‐Berzdorf, Germany), as described previously . Primer sequences of the target genes are listed in Table S1, Supporting Information.…”

Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging

“…In addition, ASX reversed the reduced expression pattern of sirtuin1 and klotho. In this study, ASX supplementation prevented liver weight loss, improved locomotive muscle function, and exerted significant anti-aging properties by reducing oxidative stress and improving the expression of age-related genes [ 90 ].…”

Natural Astaxanthin From Haematococcus Pluvialis Enhanced Antioxidant Capacity And Improved Semen Quality In Aging Layer Breeder Roosters Through The Mitogen-Activated Protein Kinase/Nuclear Factor-Erythroid 2-Related Factor 2 (MAPK/Nrf2) Pathway

“…Furthermore, an increase in dietary ASTA supplementation from 0 to 100 mg/kg linearly increased the mRNA expression of CAT (P < 0.05). Similarly, in a previous study, dietary ASTA increased the oxidative damage repair potential of mice and upregulated the mRNA levels of GPX1, SOD1, SOD2, and CAT in the liver and kidney [44]. Therefore, it would be interesting to further study the mechanism of how dietary ASTA affects semen quality in aging roosters by improving the antioxidant defense system.…”