Protective effects of aqueous extract from Cudrania tricuspidata on oxidative stress-induced neurotoxicity

Jeong, Chang-Ho; Choi, Gi Jun; Kim, Ji Hye; Kwak, Ji Hyun; Jeong, Hee Rok; Kim, Dae‐Ok; Heo, Ho Jin

doi:10.1007/s10068-010-0158-z

Cited by 27 publications

(18 citation statements)

References 25 publications

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“…[ 2 ] , Dioscorea bulbifera L. [ 3 ] , Carissa opaca [ 4 ] , Ardisia colorata R oxb . [ 5 ] , and Cudrania tricuspidata [ 6 ] , etc. It also is a major fl avonoid distributed in several foods including onions, berries, grapes, as well as red wine [ 7 -9 ] .…”

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confidence: 99%

Quantitative Determination of Myricetin in Rat Plasma by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry and its Absolute Bioavailability

et al. 2013

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Myricetin is a widely distributed bioactive flavonoid with scientific interest attributed to its anti-oxidant, antitumor, and anti-inflammatory properties. A specific and sensitive ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for identification and quantification of myricetin in rat plasma after oral and intravenous administrations. Kaempferol was used as an internal standard. Followed by β-glucuronidase and sulfatase hydrolysis and liquid-liquid extraction with ethyl acetate, the analytes were separated on an Acquity UPLC BEH C18 column (2.1×50 mm, 1.7 μm) and analyzed in the selected ion recording with a negative electrospray ionization mode. The developed method was validated for selectivity, accuracy, precision, linearity, recovery, stability and matrix effect. The assay was validated over a wide concentration range of 2-4,000 ng/mL. Intra- and inter-day precisions were all less than 13.49% and accuracy ranged from 95.75 to 109.80%. The present method was successfully applied to investigate a pharmacokinetic study of myricetin following intravenous and oral administrations to rats. The absolute bioavailability was found to be 9.62% and 9.74% at 2 oral doses (50 mg/kg and 100 mg/kg, respectively), which indicated myricetin was poorly absorbed after oral administration. To our knowledge, this is the first pharmacokinetic evaluation of myricetin as a single active pharmaceutical ingredient in preclinical studies.

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Quantitative Determination of Myricetin in Rat Plasma by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry and its Absolute Bioavailability

et al. 2013

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“…As a traditional medicine, it has been reported to have some health benefits such as anti-inflammatory (Park et al, 2006), antitumor (Zou et al, 2004), and α-glucosidase inhibitory activity (Seo et al, 2007). The root extract also showed protective effect against glutamate-induced oxidative stress in neuronal cells (Jeong et al, 2010). According to some previous research from our laboratory, twenty-eight phenolic compounds have been identified from the twigs of C. tricuspidata.…”

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confidence: 99%

Oxyresveratrol and trans-dihydromorin from the twigs of Cudrania tricuspidata as hypopigmenting agents against melanogenesis

Zheng

Zhang

et al. 2015

Journal of Functional Foods

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“…The fruits of C. tricuspidata have also been reported to contain prenylated isoflavonoids and benzylated flavonoids with anti-inflammatory and monoamine oxidase inhibitory activities. 12,13 Recent studies have reported that fruits of C. tricuspidata show protective effects on oxidative stress-induced neurotoxicity 14 and antibacterial effects through affecting membrane permeability 15 and inhibit the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of house dust mite. 16 In this study, the inhibitory effects of C. tricuspidata fruit extract and its active compound, 5,7,3′,4′-tetrahydroxy-6,8-diprenylisoflavone (THDPI), were investigated on mast cell activation through the FcεRI-mediated signaling pathways.…”

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confidence: 99%

Effects of Cudrania tricuspidata Fruit Extract and Its Active Compound, 5,7,3′,4′-Tetrahydroxy-6,8-diprenylisoflavone, on the High-Affinity IgE Receptor-Mediated Activation of Syk in Mast Cells

Lee

Kwon

Lee

et al. 2015

J. Agric. Food Chem.

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Cudrania tricuspidata fruit extract contains a rich source of prenylated flavonoids with potential antiatherosclerotic, hepatoprotective, and anti-inflammatory properties. However, the effect of C. tricuspidata fruit extracts and its active compounds on the high-affinity IgE receptor (FcεRI)-mediated signaling remains unknown. In the present study, the effect of methanol extract from the fruits of C. tricuspidata (MFC) and its active compound, 5,7,3',4'-tetrahydroxy-6,8-diprenylisoflavone (THDPI), on FcεRI-mediated signaling in mast cells was investigated. MFC and THDPI suppressed mast cell degranulation and Ca(2+) influx. MFC also interfered with IgE-FcεRI interaction and decreased FcεRIβ mRNA expression in mast cells. Furthermore, MFC and THDPI inhibited the phosphorylation of Syk, LAT, and PLCγ and F-actin redistribution. These results indicate that MFC and its active compound, THDPI, inhibit mast cell activation through the inhibition of FcεRI-mediated Syk activation, suggesting a therapeutic potential for controlling mast cell activation in inflammatory and/or allergic processes.

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Protective effects of aqueous extract from Cudrania tricuspidata on oxidative stress-induced neurotoxicity

Cited by 27 publications

References 25 publications

Quantitative Determination of Myricetin in Rat Plasma by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry and its Absolute Bioavailability

Quantitative Determination of Myricetin in Rat Plasma by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry and its Absolute Bioavailability

Oxyresveratrol and trans-dihydromorin from the twigs of Cudrania tricuspidata as hypopigmenting agents against melanogenesis

Effects of Cudrania tricuspidata Fruit Extract and Its Active Compound, 5,7,3′,4′-Tetrahydroxy-6,8-diprenylisoflavone, on the High-Affinity IgE Receptor-Mediated Activation of Syk in Mast Cells

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