Protective effect of Withania somnifera root extract on electrographic activity in a lithium‐pilocarpine model of status epilepticus

Some Nutritional and Physiological Effects of Diazepam Administration on Growing Rabbits

“…Of particular interest is the higher albumin to globulin ratio (A/G) that was observed in the diazepam -treated rabbits. Although these higher values were not significant, they may indicate an enhanced immunity of these groups and hence, may support the observed protective effect of diazepam that reported by Kulkarni et al (1998). No significant differences were detected in the plasma total lipids cholesterol and their ratio (Table -5).…”

Recent advances in elucidating the biological properties of Withania somnifera and its potential role in health benefits

“…Phytochemically, this plant is unique because it possesses the largest and most structurally diverse set of withanolides (i.e., modified steroidal molecules based on an ergostane skeleton and named after the plant) with glycowithanolides being the major bioactive constituent of W. somnifera. Because the ethnopharmacological properties of the plant include adaptogenic, anti-sedative and anti-convulsion activities, it is no surprise that the plant is employed to treat various neurological disorders, geriatric debilities, arthritis, stress and behavior-related problems (Bhattacharya et al 1987;Dhuley 2001;Kulkarni et al 1998;Ray and Gupta 1994;Schliebs et al 1973). Several modern molecular pharmacological studies have demonstrated a correlation between these therapeutic actions and one or more of the chemical constituents present in the herb (Bargagna- Mohan et al 2006;Ichikawa et al 2006;Kaileh et al 2007;Kinghorn et al 2004;Tohda et al 2005).…”

Untitled

“…1. WA isolated from WS was found to possess anti-inflammatory, anti-convulsive, anti-tumor and antioxidant activity [9][10][11] . WA showed immunosuppressive action on blymphocyte proliferation too 12 .…”