Protective effect of vitamin E on ischaemia-reperfusion injury in ovarian grafts

Nugent, David; Newton, Helen; Gallivan, Louise; Gosden, Roger G.

doi:10.1530/jrf.0.1140341

Cited by 186 publications

(111 citation statements)

References 21 publications

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“…In accordance with Nugent et al 2 who noted a temporary interruption of ovarian function after the transplant, the information in this study showed that this interruption lasted an average of 16 days in the transplanted groups, 12 days in the fresh grafts and 19 days in the cryopreserved grafts. However, this function re-initiates after the recruitment of the surviving primordial follicles.…”

Section: Discussionsupporting

confidence: 92%

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Study on the vaginal smear of rats submitted to autologous ovarian transplant: impact of remote ischemic preconditioning

et al. 2009

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Purpose:To evaluate the remote ischemic preconditioning (R-IPC) impact on the quality of the ovarian graft by means of vaginal smear of transplanted rats. Methods: Sixty rats were used divided in six groups: Control; Fresh transplant (TxF); Cryopreserved transplant (TxC); R-IPC; R-IPC + fresh transplant (TxF+R-IPC); R-IPC + cryopreserved transplant (TxC+R-IPC). R-IPC was performed in the common iliac artery. Autologous ovarian tissue was implanted integrally in the retro peritoneum. On the first PO day, vaginal smear collection was daily initiated. After 30 days, the PO day when the estrous cycle was re-initiated was considered for analysis as well as the estrous days and the number of estrous cycles. Results: R-IPC showed a tendency to an early estrus re-initiation (p>0.05) as well as increase the number of cycles in the fresh transplanted group while in the cryopreserved transplant the number of cycles was similar, regardless of the stimulus R-IPC (p>0.05). The animals which had undergone fresh grafts had a longer estrous period than the ones which had undergone cryopreserved grafts, with or without R-IPC (p<0.05). Conclusion: R-IPC promoted earlier re-initiation of ovarian activity in the PO and greater estrous frequency, with more consistent results in the fresh grafts than in the cryopreserved ones.

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Section: Discussionsupporting

confidence: 92%

“…The longer the time course of angiogenesis, the shorter is graft survival. Thus, measures to accelerate revascularization are greatly expected by specialists 1,2 .…”

Section: Introductionmentioning

confidence: 99%

Study on the vaginal smear of rats submitted to autologous ovarian transplant: impact of remote ischemic preconditioning

et al. 2009

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“…Kim et al, [31] showed that the ovarian tissue could tolerate ischaemia for at least 2 h at 0°C or at room temperature, and that a water soluble antioxidant (ascorbic acid) reduces apoptosis in ovarian cortex by up to 24 h in the case of incubation in vitro. It has been reported that treatment with vitamin E, a lipid soluble antioxidant, improved the survival of follicles in ovarian grafts by reducing ischemic injury [32]. Prolonged exogenous stimulation promoted primordial follicle maturation but also caused a loss of primordial follicles in xenotransplanted frozen-thawed ovaries [28,33].…”

Section: Discussionmentioning

confidence: 99%

Beneficial effect of desialylated erythropoietin administration on the frozen-thawed canine ovarian xenotransplantation

Suzuki

Ishijima

Maruyama

et al. 2008

J Assist Reprod Genet

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Purpose The main drawback of ovarian cryopreservation followed by transplantation is that a large proportion of follicles are lost after transplantation. Thus, effects of erythropoietin (EPO) and desialylated EPO administration on the frozen-thawed canine ovarian xenotransplantation were examined. Methods The protective and survival-promoting effects of EPO and desialylated EPO on the follicles of frozen-thawed canine ovaries after transplantation were examined using NOD-SCID mice. Frozen-thawed dog ovarian tissue with 400 U/kg of EPO or asialo EPO was placed into the ovarian bursa.Results At 4 weeks after the transplantation, the ovaries were removed and subjected to histological examination. The survival rate of early primary follicles was 15.2% in the EPO group and 157.6% in the asialo EPO group, in contrast to 10.1% in the untreated group. Conclusions These results demonstrate that administration of asialo EPO could be effectively used to enhance the survival of the follicles of transplanted cryopreserved ovaries.

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“…Nugent et al (22) tried to reduce damage by reactive oxygen species generated during ischemia and reperfusion by antioxidant vitamin E and achieved a significant improvement in follicle survival, from 45% to 72%. Schnorr et al found that VEGF administered subcutaneously at the site of ovarian transplantation in a monkey model did not improve graft survival, although their sample size was small (23).…”

Section: Discussionmentioning

confidence: 99%

Blastocyst Development After Cryopreservation and Subcutaneous Transplantation of Mouse Ovarian Tissue

Lee

Ho²,

Yu³

et al. 2005

J Assist Reprod Genet

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Purpose : To investigate follicle survival and developmental potential with IVF of cryopreserved, subcutaneously transplanted mouse ovarian tissue. Methods : Fresh and frozen mouse ovarian tissue was autologously transplanted into subcutaneous tissue. Two weeks after the transplantation, the morphology and histology of the fresh and frozen grafts were compared. Superovulation and IVF was performed to evaluate the fertility potential of the frozen ovarian graft. Results : Both fresh and frozen grafts of ovarian tissue survived in 14 of 16 mice (88%). Morphologically, both types of grafts resembled fresh ovarian tissue and contained follicles at all stages of folliculogenesis. A total of 73% of follicles in fresh grafts and 62% in frozen grafts survived after transplantation compared with fresh ovarian tissue. Sixteen ICR mice underwent superovulation. A total of 56 oocytes from antral follicles were recovered from the subcutaneously transplanted cryopreserved ovarian tissue. Fourteen (25%) oocytes were in metaphase II stage, 6 were fertilized by IVF, and 2 progressed to the blastocyst stage. Conclusions : Cryopreservation and subcutaneous transplantation of ovarian tissue provides a possible means of fertility preservation. The main loss of follicles occurred during grafting rather than during freezing and thawing.

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Protective effect of vitamin E on ischaemia-reperfusion injury in ovarian grafts

Abstract: Ovarian cortical tissue cryopreservation with subsequent autografting is a potential strategy for the preservation of fertility in patients undergoing systemic chemotherapy and pelvic radiotherapy. Non-vascular

Cited by 186 publications

References 21 publications

Study on the vaginal smear of rats submitted to autologous ovarian transplant: impact of remote ischemic preconditioning

Study on the vaginal smear of rats submitted to autologous ovarian transplant: impact of remote ischemic preconditioning

Beneficial effect of desialylated erythropoietin administration on the frozen-thawed canine ovarian xenotransplantation

Blastocyst Development After Cryopreservation and Subcutaneous Transplantation of Mouse Ovarian Tissue

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