Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin–induced diabetic nephropathy in mice

Yang, Wenjing; Li, Yanru; Gao, Hui; Wu, Xiao-Ming; Wang, Xiaoling; Wang, Xiaoning; Xiang, Lan; Ren, Dongmei; Lou, Hongxiang; Shen, Tao

doi:10.1016/j.jep.2018.08.037

Cited by 45 publications

(26 citation statements)

References 39 publications

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“…Ligusticum chuanxiong Hort was reported to inhibit TNF-α production and TNF-α mediated NF-κB activation, thus exhibiting an anti-inflammatory effect [26]. In addition, extract from Ligusticum chuanxiong Hort was reported to have antioxidant activity [27] and inhibited oxidative stress and inflammation through its reaction with Nrf2 and NF-κB pathways [28]. Angelica sinensis which is commonly used in arthritis, was found to reduce excessive synovial fibroblast proliferation in some studies.…”

Section: Discussionmentioning

confidence: 99%

A Review of Pharmacopuncture Treatment for Frozen Shoulder: A Literature Review of Clinical Trials

정성목¹,

김성진²,

윤진영³

et al. 2018

J Acupunct Res

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The objective of this study was to review clinical trials of pharmacopuncture treatment for Frozen Shoulder and to evaluate trends in this field. The literature search was performed using PubMed, the Cochrane Library, China National Knowledge Infrastructure, and 5 Korean electronic databases. A combination of "pharmacopuncture," "acupoint injection," "Frozen Shoulder," "adhesive capsulitis," and "periarthritis of shoulder" search terms were used. A total of 9 studies were included in this review. The studies were classified into herbal extract-based (5 types) and animal-based (2 types) pharmacopuncture treatment of Frozen Shoulder. There were 14 different acupoints and Ashi points used in the 9 studies. The total volume of herbal extract-based pharmacopuncture injected was usually between 2 mL and 4 mL, and for animalbased pharmacopuncture it was 1 ml. In most studies of Frozen Shoulder, pain was reduced and function was significantly improved after pharmacopuncture treatment. These results demonstrate that pharmacopuncture alleviates pain and restores function in patients with Frozen Shoulder. Further studies must be conducted on pharmacopuncture for management of Frozen Shoulder.

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Section: Discussionmentioning

confidence: 99%

A Review of Pharmacopuncture Treatment for Frozen Shoulder: A Literature Review of Clinical Trials

정성목¹,

김성진²,

윤진영³

et al. 2018

J Acupunct Res

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“…Stephaniae Tetrandrae Radix (STR), and Chuanxiong Rhizoma (CRH). Furthermore, some single-flavor herbs or ingredients in SBT, such as Astragaloside IV of HMM, paeoniflorin of PRA, and CRH have also been revealed an exact therapeutic effect against proteinuria [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Identifying Synergistic Mechanisms of Multiple Ingredients in Shuangbai Tablets against Proteinuria by Virtual Screening and a Network Pharmacology Approach

Hao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Shuangbai Tablets (SBT), a traditional herbal mixture, has shown substantial clinical efficacy. However, a systematic mechanism of its active ingredients and pharmacological mechanisms of action against proteinuria continues being lacking. A network pharmacology approach was effectual in discovering the relationship of multiple ingredients and targets of the herbal mixture. This study aimed to identify key targets, major active ingredients, and pathways of SBT against proteinuria by network pharmacology approach combined with thin layer chromatography (TLC). Human phenotype (HP) disease analysis, gene ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, and molecular docking were used in this study. To this end, a total of 48 candidate targets of 118 active ingredients of SBT were identified. Network analysis showed PTGS2, ESR1, and NOS2 to be the three key targets, and beta-sitosterol, quercetin, and berberine were the three major active ingredients; among them one of the major active ingredients, quercetin, was discriminated by TLC. These results of the functional enrichment analysis indicated that the most relevant disease including these 48 candidate proteins is proteinuria, SBT treated proteinuria by sympathetically regulating multiple biological pathways, such as the HIF-1, RAS, AGE-RAGE, and VEGF signaling pathways. Additionally, molecular docking validation suggested that major active ingredients of SBT were capable of binding to HIF-1A and VEGFA of the main pathways. Consequently, key targets, major active ingredients, and pathways based on data analysis of SBT against proteinuria were systematically identified confirming its utility and providing a new drug against proteinuria.

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“…What's more, Chuanxiong is a frequently prescribed component in many TCM formulas for the therapy of DN [10] [11]. Some researchers have shown that Chuanxiong injection can provide protective effect in patients with DN [12], improve renal function (blood urea nitrogen [BUN] and serum creatinine [SCr]) and reduce in urine protein [13]. However, the mechanism of Chuanxiong Rhizoma in DN has not yet been fully studied.…”

Section: Introductionmentioning

confidence: 99%

Research on the Potential Mechanism of Chuanxiong Rhizoma on Treating Diabetic Nephropathy Based on Network Pharmacology

Chen

et al. 2020

Preprint

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Background: Chuanxiong Rhizoma is one of the traditional Chinese medicines which have been used for years in the treatment of diabetic nephropathy (DN). However, the mechanism of Chuanxiong Rhizoma in DN has not yet been fully understood. Methods: We performed network pharmacology to construct targeted proteins interaction network of Chuanxiong Rhizoma. Active ingredients were acquired from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. DRUGBANK database was used to predict targeted proteins of Chuanxiong Rhizoma. Gene ontology (GO) biological process analyses and KEGG pathway enrichment analyses were also performed for functional prediction of the targeted proteins. Molecular docking was applied for evaluating the drug interactions between hub targets and active ingredients. Results: Twenty-eight targets fished by 6 active ingredients of Chuanxiong Rhizoma were obtained in the study. The top 10 significant GO analyses, as well as 6 KEGG pathways, were enriched for genomic analysis. We also acquired 1366 differentially expressed genes associated with DN from GSE30528 dataset, including five targeted genes: KCNH2, NCOA1, KDR, NR3C2 and ADRB2. Molecular docking analysis successfully combined KCNH2, NCOA1, KDR and ADRB2 to Myricanone with docking scores from 4.61 to 6.28. NR3C2 also displayed good binding forces (8.13 and 8.34) with Wallichilide and Sitosterol, revealing good binding forces to active compounds of Chuanxiong Rhizoma. Conclusions: Chuanxiong Rhizoma might take part in the treatment of DN through pathways associated with steroid hormone, estrogen, thyroid hormone and IL-17. KCNH2, NCOA1, KDR, ADRB2 and NR3C2 were proved to be the hub targets closely related to corresponding active ingredients of Chuanxiong Rhizoma.

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Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin–induced diabetic nephropathy in mice

Cited by 45 publications

References 39 publications

A Review of Pharmacopuncture Treatment for Frozen Shoulder: A Literature Review of Clinical Trials

A Review of Pharmacopuncture Treatment for Frozen Shoulder: A Literature Review of Clinical Trials

Identifying Synergistic Mechanisms of Multiple Ingredients in Shuangbai Tablets against Proteinuria by Virtual Screening and a Network Pharmacology Approach

Research on the Potential Mechanism of Chuanxiong Rhizoma on Treating Diabetic Nephropathy Based on Network Pharmacology

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