Protective effect of sodium molybdate against the acute toxicity of cadmium chloride

Influence of dietary iron deficiency on acute metal intoxication

“…The increase in hepatic zinc in response to nickel, lead or cadmium administration in normal-diet fed animals, in response to cadmium in iron deficientdiet fed animals and the increase in renal zinc and copper in response to cadmium injection both in normal-diet fed as well as in iron deficient-diet fed animals could be attributed to the induction of tissue MT by these toxic metals, capable of strongly binding additional zinc and copper 9 The increase in hepatic calcium and iron levels following nickel, lead or cadmium administration, particularly in normaldiet fed animals, may be the result of their increased uptake or retention upon heavy metal exposure 9 However, the extent of cadmium induced hepatic and renal MT and lead or nickel induced hepatic MT appears related to the intracellular calcium levels in the present study 9 A simultaneous rise in calcium and MT has also been shown by Yamane et al (1990) in rats at 12 h after the subcutaneous administration of CdC12. …”

Influence of dietary iron deficiency on acute metal intoxication

“…The increase in hepatic zinc in response to nickel, lead or cadmium administration in normal-diet fed animals, in response to cadmium in iron deficientdiet fed animals and the increase in renal zinc and copper in response to cadmium injection both in normal-diet fed as well as in iron deficient-diet fed animals could be attributed to the induction of tissue MT by these toxic metals, capable of strongly binding additional zinc and copper 9 The increase in hepatic calcium and iron levels following nickel, lead or cadmium administration, particularly in normaldiet fed animals, may be the result of their increased uptake or retention upon heavy metal exposure 9 However, the extent of cadmium induced hepatic and renal MT and lead or nickel induced hepatic MT appears related to the intracellular calcium levels in the present study 9 A simultaneous rise in calcium and MT has also been shown by Yamane et al (1990) in rats at 12 h after the subcutaneous administration of CdC12. …”

Açaí (Euterpe oleraceaMart.): A Tropical Fruit with High Levels of Essential Minerals—Especially Manganese—and its Contribution as a Source of Natural Mineral Supplementation

“…A diet rich in these minerals protects the organism from toxic environmental effects (Grotto et al, 2009;Yamane et al, 1990). The concentrations of these minerals were also significant in açaí fruit and comparable with values found in other food sources in the human diet (FDA, 2010).…”

Protective effects of sodium molybdate on carbon tetrachloride-induced hepatotoxicity in rats

“…The observation that the levels of SOD and CAT were brought down to their normal levels in the CCl 4 + sodium molybdate-treated rats indicates that the liver is restored to its normal activity by the hepatoprotective action of sodium molybdate. It has been reported that sodium molybdate alleviates the acute toxicity of CdCl 2 in rats, and the protective mechanism of the metal is in part related to its enhancement of liver Cd-metallothionen induction [34].…”

Influence of dietary iron deficiency on acute metal intoxication

“…The increase in hepatic zinc in response to nickel, lead or cadmium administration in normal-diet fed animals, in response to cadmium in iron deficientdiet fed animals and the increase in renal zinc and copper in response to cadmium injection both in normal-diet fed as well as in iron deficient-diet fed animals could be attributed to the induction of tissue MT by these toxic metals, capable of strongly binding additional zinc and copper 9 The increase in hepatic calcium and iron levels following nickel, lead or cadmium administration, particularly in normaldiet fed animals, may be the result of their increased uptake or retention upon heavy metal exposure 9 However, the extent of cadmium induced hepatic and renal MT and lead or nickel induced hepatic MT appears related to the intracellular calcium levels in the present study 9 A simultaneous rise in calcium and MT has also been shown by Yamane et al (1990) in rats at 12 h after the subcutaneous administration of CdC12. …”

Açaí (Euterpe oleraceaMart.): A Tropical Fruit with High Levels of Essential Minerals—Especially Manganese—and its Contribution as a Source of Natural Mineral Supplementation

“…A diet rich in these minerals protects the organism from toxic environmental effects (Grotto et al, 2009;Yamane et al, 1990). The concentrations of these minerals were also significant in açaí fruit and comparable with values found in other food sources in the human diet (FDA, 2010).…”

Protective effects of sodium molybdate on carbon tetrachloride-induced hepatotoxicity in rats

“…The observation that the levels of SOD and CAT were brought down to their normal levels in the CCl 4 + sodium molybdate-treated rats indicates that the liver is restored to its normal activity by the hepatoprotective action of sodium molybdate. It has been reported that sodium molybdate alleviates the acute toxicity of CdCl 2 in rats, and the protective mechanism of the metal is in part related to its enhancement of liver Cd-metallothionen induction [34].…”

Influence of dietary iron deficiency on acute metal intoxication

“…The increase in hepatic zinc in response to nickel, lead or cadmium administration in normal-diet fed animals, in response to cadmium in iron deficientdiet fed animals and the increase in renal zinc and copper in response to cadmium injection both in normal-diet fed as well as in iron deficient-diet fed animals could be attributed to the induction of tissue MT by these toxic metals, capable of strongly binding additional zinc and copper 9 The increase in hepatic calcium and iron levels following nickel, lead or cadmium administration, particularly in normaldiet fed animals, may be the result of their increased uptake or retention upon heavy metal exposure 9 However, the extent of cadmium induced hepatic and renal MT and lead or nickel induced hepatic MT appears related to the intracellular calcium levels in the present study 9 A simultaneous rise in calcium and MT has also been shown by Yamane et al (1990) in rats at 12 h after the subcutaneous administration of CdC12. …”

Açaí (Euterpe oleraceaMart.): A Tropical Fruit with High Levels of Essential Minerals—Especially Manganese—and its Contribution as a Source of Natural Mineral Supplementation

“…A diet rich in these minerals protects the organism from toxic environmental effects (Grotto et al, 2009;Yamane et al, 1990). The concentrations of these minerals were also significant in açaí fruit and comparable with values found in other food sources in the human diet (FDA, 2010).…”

Protective effects of sodium molybdate on carbon tetrachloride-induced hepatotoxicity in rats

“…The observation that the levels of SOD and CAT were brought down to their normal levels in the CCl 4 + sodium molybdate-treated rats indicates that the liver is restored to its normal activity by the hepatoprotective action of sodium molybdate. It has been reported that sodium molybdate alleviates the acute toxicity of CdCl 2 in rats, and the protective mechanism of the metal is in part related to its enhancement of liver Cd-metallothionen induction [34].…”