Protective effect of resveratrol against endotoxemia-induced lung injury involves the reduction of oxidative/nitrative stress

Zhang, Hongxia; Duan, Guoli; Wang, Chang-Nan; Zhang, Yun‐Qian; Zhu, Xiaoyan; Liu, Yujian

doi:10.1016/j.pupt.2013.07.007

Cited by 45 publications

(50 citation statements)

References 47 publications

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“…Resveratrol is known to exert potent anti-oxidant activities via scavenging ROS [22], as well as enhancing the activity of anti-oxidant enzymes such as catalase and glutathione peroxidase [24]. Accumulating data have shown that resveratrol alleviates LPS-induced oxidative stress in a variety of organs such as lung [12], kidney [25,26] and heart [27]. In the present study, we provided several line of evidence that resveratrol treatment significantly alleviated oxidative stress in the adrenal gland during endotoxemia.…”

Section: Resveratrol Improves Lps-induced Adrenal Insufficiencysupporting

confidence: 57%

“…Moreover, resveratrol increase iNOS activity in primary cultured rat vascular smooth muscle cells [36]. Although the above-mentioned literatures have reported that resveratrol treatment leads to enhanced expression or activity of iNOS, there are plenty of studies demonstrating that resveratrol decreases iNOS expression and NO production induced by various proinflammatory stimuli such as LPS [12] and interferon-γ [37]. Consistent with most of the literature in this area, we found that resveratrol significantly suppressed LPSinduced iNOS expression, NO production, and nitrotyrosine formation in the adrenal gland.…”

Section: Discussionmentioning

confidence: 96%

“…Our previous study has demonstrated that resveratrol ameliorates endotoxemia-associated acute lung injury through reducing oxidative/nitrative stress in lung tissues [12]. Thus, the present study aimed to investigate the effect of resveratrol on adrenal insufficiency in a model of endotoxemia; and then explored whether resveratrol affected oxidiative/nitrative stress in adrenal glands in this model.…”

Section: Acth Stimulation Testsmentioning

confidence: 93%

“…Homogenates were then centrifuged at 1,000 g for 10 min. The total antioxidant capacity (T-AOC), superoxide dismutase (SOD) and catalase (CAT) activity in adrenal glands tissue were determined according to the kit manufacturer's instructions (Winching, Nanjing, China) as described previously [12]. The mean intra-assay coefficients of variation for T-AOC, SOD and CAT were 3.2%, 1.7% and 1.9%, respectively.…”

Section: Measurement Of Total Antioxidant Capacity and Activities Of mentioning

confidence: 99%

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Resveratrol alleviates endotoxemia-associated adrenal insufficiency by suppressing oxidative/nitrative stress

et al. 2016

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Section: Resveratrol Improves Lps-induced Adrenal Insufficiencysupporting

confidence: 57%

Section: Discussionmentioning

confidence: 96%

Section: Acth Stimulation Testsmentioning

confidence: 93%

Section: Measurement Of Total Antioxidant Capacity and Activities Of mentioning

confidence: 99%

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Resveratrol alleviates endotoxemia-associated adrenal insufficiency by suppressing oxidative/nitrative stress

et al. 2016

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“…Though not yet confirmed in a stroke model, resveratrol scavenges ONOO - and inhibits protein nitration in several other models [139,140,141]. Moreover, liquid chromatography with tandem electrospray mass spectrometry showed that resveratrol is a substrate of ONOO - .…”

Section: Active Compounds From Chinese Herbal Medicine For Targeting mentioning

confidence: 99%

Targeting ONOO<sup>-</sup>/HMGB1/MMP-9 Signaling Cascades: Potential for Drug Development from Chinese Medicine to Attenuate Ischemic Brain Injury and Hemorrhagic Transformation Induced by Thrombolytic Treatment

Chen¹,

Guan²,

Shen³

2016

Integr Med Int

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Stroke is the leading cause of death and disability worldwide, and ischemic stroke accounts for more than 85% of the stroke incidence. Tissue plasminogen activator (t-PA) is the only FDA-approved drug for ischemic stroke treatment with a narrow treatment time window of 4.5 h. Hemorrhagic transformation (HT) is a severe complication of delayed t-PA treatment in ischemic stroke. Thus, it is critically important to develop combination therapies to reduce HT and extend the therapeutic time window of t-PA. Current progress suggests that peroxynitrite (ONOO^-)/high-mobility group box 1 protein (HMGB1)/matrix metalloproteinase-9 (MMP-9) signaling cascades could be important for attenuating HT during thrombolytic treatment for acute ischemic stroke. Recently, important progress has been made in seeking for natural compounds from Chinese medicine for reducing ischemic stroke injury, with some of them targeting ONOO^-/HMGB1/MMP-9 signaling cascades. Herein, we analyze the roles and interactions of these three targets in mediating HT; subsequently, we summarize the potential compounds from Chinese herbal medicine for attenuating HT and analyze the related targets. Finally, we raise the potential issues to be addressed in further development of these compounds as combination therapy.

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Resveratrol Protects against Cigarette Smoke–Induced Oxidative Damage and Pulmonary Inflammation

Liu

Ren

Chen

et al. 2014

J Biochem & Molecular Tox

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This study was carried out to investigate the effects of resveratrol on cigarette smoke (CS)-induced lung injury. Experimental mice were administrated with 1 mg/kg or 3 mg/ kg resveratrol orally, 1 h prior to CS exposure (five cigarettes a day for 3 consecutive days). Airway inflammation and gene expression changes were assessed. CS exposure increased the number of pulmonary inflammatory cells, coupled with elevated production of tumor necrosis factor α and interleukin-6 in bronchoalveolar lavage fluids. Resveratrol treatment decreased CS-induced lung inflammation. Resveratrol restored the activities of superoxide dismutase, GSH peroxidase, and catalase in CS-treated mice. CS significantly enhanced the nuclear translocation of nuclear factor κB (NF-κB) and NF-κB DNA binding activity, which was impaired by resveratrol pretreatment. In addition, resveratrol promoted CS-induced heme oxygenase-1 (HO-1) expression and activation. Our results collectively indicate that resveratrol attenuates CS-induced lung oxidative injury, which involves decreased NF-κB activity and the elevated HO-1 expression and activity.

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Protective effect of resveratrol against endotoxemia-induced lung injury involves the reduction of oxidative/nitrative stress

Cited by 45 publications

References 47 publications

Resveratrol alleviates endotoxemia-associated adrenal insufficiency by suppressing oxidative/nitrative stress

Resveratrol alleviates endotoxemia-associated adrenal insufficiency by suppressing oxidative/nitrative stress

Targeting ONOO<sup>-</sup>/HMGB1/MMP-9 Signaling Cascades: Potential for Drug Development from Chinese Medicine to Attenuate Ischemic Brain Injury and Hemorrhagic Transformation Induced by Thrombolytic Treatment

Resveratrol Protects against Cigarette Smoke–Induced Oxidative Damage and Pulmonary Inflammation

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