Protective effect of quercetin on experimental chronic cadmium nephrotoxicity in rats is based on its antioxidant properties

Morales, Ana Isabel; Vicente-Sánchez, C.; Sandoval, Juan Marcelo; Egido, Jaime; Mayoral, Paula; Arévalo, Miguel; Fernandez-Tagarro, Maria; López‐Novoa, José M.; Pérez‐Barriocanal, Fernando

doi:10.1016/j.fct.2006.07.012

Cited by 162 publications

(110 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our previous study we have demonstrated that in the subacute cadmium intoxication model in mice this metal significantly accumulated in the liver and kidneys and exerted Cd- In rats, during chronic cadmium administration, renal superoxide dismutase activity was higher in the group receiving Cd with quercetin than in the group receiving only Cd (Morales et al, 2006). In our study we also observed similar action.…”

Section: Discussionsupporting

confidence: 87%

“…At higher Cd doses a decreased GSH level was observed probably as a result of generation of reactive oxygen species exceeding the ability to regenerate reduced glutathione (Stohs and Bagchi, 1995). In our work we observed significant glutathione depletion probably as a result of glutathione storage consumption after 28 days of cadmium poisoning (Figure 1 It was demonstrated that in chronic cadmium administration resulted in higher renal glutathione-reductase activity in the rats receiving Cd with quercetin than those receiving only cadmium (Morales et al, 2006). In our experiment we observed that NaQSA significantly prevented cadmium-induced GSH depletion in the mouse liver (Figure 1).…”

Section: Discussionsupporting

confidence: 56%

See 1 more Smart Citation

Influence of water-soluble flavonoids, quercetin-5′-sulfonic acid sodium salt and morin-5′-sulfonic acid sodium salt, on antioxidant parameters in the subacute cadmium intoxication mouse model

Chlebda

Magdalan

Merwid-Ląd

et al. 2010

Experimental and Toxicologic Pathology

View full text Add to dashboard Cite

, et al.. Influence of water-soluble flavonoids: Quercetin5'-sulfonic acid sodium salt and morin-5'-sulfonic acid sodium salt on antioxidant parameters in the subacute cadmium intoxication mouse model. Experimental and Toxicologic Pathology, Elsevier, 2010, 62 (2) Cite this article as: Ewa Chlebda, Jan Magdalan, Anna Merwid-La Rd, Małgorzata Trocha, Maria Kopacz, Anna Kuźniar, Dorota Nowak and Adam Szela R g, Influence of water-soluble flavonoids: Quercetin-5'-sulfonic acid sodium salt and morin-5'-sulfonic acid sodium salt on antioxidant parameters in the subacute cadmium intoxication mouse model, Experimental and Toxicologic Pathology (2009), doi:10.1016/j.etp.2009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Water-soluble quercetin-5'-sulfonic acid sodium salt (NaQSA) and morin-5'-sulfonic acid sodium salt (NaMSA) could exert an antagonistic effect on cadmium intoxication. The aim of the study was to examine the influence of these substances on superoxide dismutase (SOD) and glutathione (GSH) levels in the mouse liver in the subacute cadmium intoxication model. NaQSA and NaMSA signicificantly counteracted cadmium-induced decreases in SOD and GSH levels. No significant differences in SOD and GSH levels between groups exposed to cadmium receiving NaQSA or/and NaMSA were observed.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 56%

Influence of water-soluble flavonoids, quercetin-5′-sulfonic acid sodium salt and morin-5′-sulfonic acid sodium salt, on antioxidant parameters in the subacute cadmium intoxication mouse model

Chlebda

Magdalan

Merwid-Ląd

et al. 2010

Experimental and Toxicologic Pathology

View full text Add to dashboard Cite

show abstract

“…The administration of flower and leaf fractions of H. rosa sinensis, possessing reasonable antioxidant potential [36], may have protected the renal functions from Cd-induced toxicity by significantly restoring the serum and urine urea and creatinine levels. The present study supports the findings of [43]. Various results suggest that plant extracts may prevent nephrotoxicity by suppressing the oxidative stress caused by Cd [31, 37,[44][45][46].…”

Section: Status Of Urine and Serum Renal Markersupporting

confidence: 79%

Amelioration of Hepato-Renal Toxicity by a Flavonoid-Rich Fraction of Hibiscus rosa-sinenses (Leaves and Flowers) in Male Rabbits Intoxicated by Cadmium

Hussain

Chaudhary

Anjum

et al. 2017

Pol. J. Environ. Stud.

View full text Add to dashboard Cite

This study was initiated to anticipate the potential protective effects of flavonoid-rich fractions of Hibiscus rosa-sinenses flowers (HF) and leaves (HL) on cadmium (Cd)-induced toxicity in adult albino rabbits. Cd, being a prominent environmental pollutant, poses a threat for its widespread range of toxic expressions. A dramatic increase in total phenolics, flavonoids, and antioxidant capacity has been observed in flavonoid-rich fractions of HF and HL as compared to their crude extracts, suggesting for the rationale for their use in this study. Thirty-six male rabbits were indiscriminately allocated into six groups, including control, Cd (6.1 mg Cd/kg/day), HF and HL (200 mg HF & HL /Kg/day), Cd+HF, and Cd+HL (receiving the same doses of Cd, HF, and HL) groups. Treatment (p.o) for 60 days resulted in improvement of weight gain in Cd+HF and Cd+HL groups in comparison with the Cd group. Treatment with Cd+HF showed better results than Cd+HL by significantly decreasing (p<0.05) transaminases (AST, ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), and creatinine and urea levels, while total bilirubin and albumin were increased on the 15 th , 30 th , 45 th , and 60 th days in a progressive manner when compared with the Cd receiving group. Likewise, the Cd+HF group showed better activities than Cd+HL by significantly increasing (p<0.05) superoxide dismutase, catalase, and vitamins C and E, while LPO and Cd concentrations were significantly decreased in the liver and kidney tissues when compared with Cd-intoxicated bucks.Values of these parameters in only HF and HL-receiving groups were near the control. The histopathological

show abstract

“…Also, in another study, the increase of the SOD activity has been reported after quercetin treatment 86,89 . Protective effect of quercetin on experimental chronic cadmium nephrotoxicity on rats has been evaluated and increase of the SOD activity by the quercetin has been detected 87 . In the previous study, it has been noted that the activities of SOD and CAT have been increased by the quercetin 88 .…”

Section: Resultsmentioning

confidence: 99%

Quercetin protects rat skeletal muscle from ischemia reperfusion injury

Akdemir

Gülçın

Karagöz

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

In this study, we investigated the potential beneficial effects of quercetin on skeletal muscle ischemia reperfusion injury. Twenty-four Sprague-Dawley type rats were randomly divided into four groups. In the sham group, only gastrocnemius muscle were removed and given no quercetin. In ischemia group, all the femoral artery, vein and collaterals were occluded in the left hindlimb by applying tourniquate under general anaesthesia for three hours but reperfusion was not done. In the Quercetin + Ischemia reperfusion group, quercetin (200 mg kg À1 dose orally) was given during one-week reoperation and later ischemia reperfusion model was done. Finally, gastrocnemius muscle samples were removed to measure biochemical parameters. The biomarkers, MDA levels, SOD, CAT and GPx activities, were evaluated related to skeletal muscle ischemia reperfusion injury. MDA levels reduced and SOD, CAT and GPx activities increased significantly in Quercetin + Ischemia reperfusion group. Results clearly showed that Quercetin have a protective role against oxidative damage induced by ischemia reperfusion in rats.

show abstract

Protective effect of quercetin on experimental chronic cadmium nephrotoxicity in rats is based on its antioxidant properties

Cited by 162 publications

References 42 publications

Influence of water-soluble flavonoids, quercetin-5′-sulfonic acid sodium salt and morin-5′-sulfonic acid sodium salt, on antioxidant parameters in the subacute cadmium intoxication mouse model

Influence of water-soluble flavonoids, quercetin-5′-sulfonic acid sodium salt and morin-5′-sulfonic acid sodium salt, on antioxidant parameters in the subacute cadmium intoxication mouse model

Amelioration of Hepato-Renal Toxicity by a Flavonoid-Rich Fraction of Hibiscus rosa-sinenses (Leaves and Flowers) in Male Rabbits Intoxicated by Cadmium

Quercetin protects rat skeletal muscle from ischemia reperfusion injury

Contact Info

Product

Resources

About