J. Neurosci. Res. volume 86, issue 3, P653-659 2008 DOI: 10.1002/jnr.21506 View full text
Ingrid Dupiereux, Nandini Falisse-Poirrier, Willy Zorzi, Nicole T. Watt, Olivier Thellin, Danièle Zorzi, Olivier Pierard, Nigel M. Hooper, Ernst Heinen, Benaïssa Elmoualij

Abstract: Transmissible spongiform encephalopathies are a group of neurodegenerative disorders caused by a posttranslational, conformational change in the cellular isoform of the prion protein (PrP(C)) into an infectious, disease-associated form (PrP(Sc)). Increasing evidence supports a role for PrP(C) in the cellular response to oxidative stress. We investigated the effect of oxidative stress mediated by paraquat exposure on SH-SY5Y neuroblastoma cells. A loss of mitochondrial membrane potential and subsequent reductio…

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