Protective Effect of Parsley Juice (<i>Petroselinum crispum</i>, Apiaceae) against Cadmium Deleterious Changes in the Developed Albino Mice Newborns (<i>Mus musculus</i>) Brain

Allam, Ahmed A.; Maodaa, Salah N.; Abo‐Eleneen, Rasha E.; Ajarem, Jamaan S.

doi:10.1155/2016/2646840

Cited by 26 publications

(28 citation statements)

References 50 publications

(69 reference statements)

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“…The pups from groups T and F, therefore, suffered from exposure to excess elements perinatally. The mother’s exposure to the excess elements during their life may have induced behavioural changes due, which may have an effect on the pups’ lactation index, meaning that the pups from groups F and T may have been exposed to malnutrition (Allam et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…The small litter size in groups T and F compared to group C may be due to the exposure to harmful elements perinatally. Allam et al (2016) reported that heavy metal (such as cadmium) toxicity induces a reduction in litter size reduction due to embryo resorption.…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, Visavadiya et al (2015) reported that the induction of lipid peroxidation in different tissues increases the thiobarbituric acid-reactive substances (TBARS) due to the depletion of glutathione (GSH). Thiols are vital cellular antioxidants and protect animals’ cells from free radicals (Allam et al, 2016), and GSH is recognized as the principal endogenous thiol that acts as a redox buffer in our body (Visavadiya et al, 2015). Metals polluting water include well-documented neurotoxicants that produce pathology both in the peripheral and central developed nervous system, as well as in the liver and kidney (Maodaa et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Drinking desalinated seawater for a long time induces anomalies in the development of new-born albino rats

Allam¹

2017

Saudi Journal of Biological Sciences

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The present study aimed to elucidate the abnormalities in the development of rat brains, livers, kidney and behaviours after drinking desalinated seawater prenatally. Three types of drinking water were employed as an experimental probe (bottled water, filtered desalinated seawater and tap desalinated seawater) to investigate neurobehavioral and morphological changes in the development of pup rats. Female rats from each group were administered water from their birth until gestation and lactation. The 1st and 2nd generation pups were divided into three groups: Group C, mothers and pups administered with bottled drinking water (the control group); Group F, mothers and pups administered with filtered drinking water; Group T, mothers and pups administered with unfiltered desalinated seawater (tap water). Morphological changes (CNS aberration) and neurobehavioral changes were studied. The aberrations recorded in the tissues (brain, liver, kidney and spinal cord) of rats from groups T and F may be due to oxidative stress in these tissues such as reduced glutathione, lipid peroxidation, peroxidase and super oxide dismutase. In conclusion, drinking desalinated seawater for a long time may cause teratogenic effects in the development of New-born rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Drinking desalinated seawater for a long time induces anomalies in the development of new-born albino rats

Allam¹

2017

Saudi Journal of Biological Sciences

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“…Hepatic damage caused by oxidative stress [29,36] can be protected either by employing strong antioxidants that inhibit the generation of free radicals. Several outcomes of a number of studies have also ascertained the protective effects of plant extracts on Cd-induced hepatotoxicity [1,[37][38][39].…”

Section: Status Of Serum Hepatic Marker Enzymesmentioning

confidence: 99%

Amelioration of Hepato-Renal Toxicity by a Flavonoid-Rich Fraction of Hibiscus rosa-sinenses (Leaves and Flowers) in Male Rabbits Intoxicated by Cadmium

Hussain

Chaudhary

Anjum

et al. 2017

Pol. J. Environ. Stud.

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This study was initiated to anticipate the potential protective effects of flavonoid-rich fractions of Hibiscus rosa-sinenses flowers (HF) and leaves (HL) on cadmium (Cd)-induced toxicity in adult albino rabbits. Cd, being a prominent environmental pollutant, poses a threat for its widespread range of toxic expressions. A dramatic increase in total phenolics, flavonoids, and antioxidant capacity has been observed in flavonoid-rich fractions of HF and HL as compared to their crude extracts, suggesting for the rationale for their use in this study. Thirty-six male rabbits were indiscriminately allocated into six groups, including control, Cd (6.1 mg Cd/kg/day), HF and HL (200 mg HF & HL /Kg/day), Cd+HF, and Cd+HL (receiving the same doses of Cd, HF, and HL) groups. Treatment (p.o) for 60 days resulted in improvement of weight gain in Cd+HF and Cd+HL groups in comparison with the Cd group. Treatment with Cd+HF showed better results than Cd+HL by significantly decreasing (p<0.05) transaminases (AST, ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), and creatinine and urea levels, while total bilirubin and albumin were increased on the 15 th , 30 th , 45 th , and 60 th days in a progressive manner when compared with the Cd receiving group. Likewise, the Cd+HF group showed better activities than Cd+HL by significantly increasing (p<0.05) superoxide dismutase, catalase, and vitamins C and E, while LPO and Cd concentrations were significantly decreased in the liver and kidney tissues when compared with Cd-intoxicated bucks.Values of these parameters in only HF and HL-receiving groups were near the control. The histopathological

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“…Exposure to the metal along with nutritional deficiency augments the toxic effects in women during reproductive age (Wright and Baccarelli, 2007). Such exposure is precarious for the fetus and may lead to a course of diseases in adulthood, particularly neurodegenerative diseases (Allam et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Prevention of cadmium-induced neurotoxicity in rats by essential nutrients present in nuts

Batool¹,

Agha²,

Tabassum³

et al. 2019

Acta Neurobiologiae Experimentalis

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Cadmium, a heavy metal with no physiological function in the human body, is considered a bio-hazard. It is also considered to be a potent neurotoxin. The primary sources of cadmium exposure are diet and cigarette smoke. It has been postulated that nutritional deficiencies can increase the risk of cadmium toxicity. Nuts provide essential nutrients which are necessary for the maintenance of brain health in humans. The present study was designed to investigate the possible protective effects of almond and walnut supplementation on cadmium-induced neurotoxicity. Cadmium was orally administered at a dose of 50 mg/kg weekly with or without the supplementation of almond and walnut in rats. Intensities of depression-and anxiety-related behaviors were assessed by the forced swim test and light/dark transition test, respectively. Memory function was also evaluated by the elevated plus maze, Morris water maze and novel object recognition task. After four weeks of treatment it was observed that cadmium administration significantly induced depressogenic and anxiogenic behaviors. Memory function was also impaired by cadmium administration. Cadmium-treated rats exhibited reduced noradrenalin, dopamine and serotonin levels in the brain, whereas the levels of their respective metabolites were significantly increased. The dietary supplementation of almond and walnut at a dose of 400 mg/kg/day significantly attenuated cadmium-induced depression, anxiety and memory impairments. Neurochemical aberrations also normalized following supplementation with these nuts in rats. The present study demonstrates that long-term supplementation with almond and walnut provides essential nutrients which may overcome nutritional deficiencies and thereby reduce heavy-metal intoxication.

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Protective Effect of Parsley Juice (Petroselinum crispum, Apiaceae) against Cadmium Deleterious Changes in the Developed Albino Mice Newborns (Mus musculus) Brain

Cited by 26 publications

References 50 publications

Drinking desalinated seawater for a long time induces anomalies in the development of new-born albino rats

Drinking desalinated seawater for a long time induces anomalies in the development of new-born albino rats

Amelioration of Hepato-Renal Toxicity by a Flavonoid-Rich Fraction of Hibiscus rosa-sinenses (Leaves and Flowers) in Male Rabbits Intoxicated by Cadmium

Prevention of cadmium-induced neurotoxicity in rats by essential nutrients present in nuts

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