Protective effect of naringin against ankylosing spondylitis via ossification, inflammation and oxidative stress in mice

Liu, Kang; Wu, Lianguo; Shi, Xiaolin; Wu, Fengqing

doi:10.3892/etm.2016.3410

Cited by 18 publications

(18 citation statements)

References 35 publications

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“…Considering the delay in diagnosis and insufficient effective therapeutic options available, identification and development of more effective compounds become inevitable. Recently, much research has been focused on the efficacy of plant-derived compounds in AS [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

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Punicalagin Exerts Protective Effects against Ankylosing Spondylitis by Regulating NF-κB-TH17/JAK2/STAT3 Signaling and Oxidative Stress

Feng

Yang

Wang

et al. 2020

BioMed Research International

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Background. Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by sacroiliitis and spinal rigidity of the axial joints. The role of oxidative stress and increased proinflammatory cytokines is well documented in AS pathogenesis. Punicalagin (2,3-hexahydroxydiphenoyl-gallagyl-D-glucose), an ellagitannin widely present in pomegranates, is found to exhibit potent anti-inflammatory, antiproliferative, and antioxidative effects. The present study was undertaken to investigate the effects of punicalagin in a rodent model of AS. Methods. BALB/c mice induced spondylitis were sacrificed 24 h after the last injection of proteoglycan extract. Histological scoring was done to assess the degree of the disease. The expression of JAK2/STAT3 proteins and proteins of the nuclear factor-κB (NF-κB) pathway was determined by immunoblotting. Serum levels of inflammatory mediators—TNF-α, IL-1β, IL-6, IL-17A, and IL-23—were assessed. Levels of lipid peroxidation and reactive oxygen species (ROS) were quantified. Antioxidant status as a measure of activities of antioxidant enzymes—catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD)—was determined. Results. Punicalagin effectively improved antioxidant status and decreased lipid peroxidation, ROS production, and serum levels of inflammatory mediators. NF-κB pathway and JAK2/STAT3 signaling were significantly (p<0.05) downregulated. Punicalagin effectively regulated the production of cytokines by the Th17 cells and the IL-17A/IL-23 axis. Conclusion. The observations suggest that punicalagin exerts a protective role in AS via reducing oxidative stress and regulating NF-κB/TH17/JAK2/STAT3 signal. Punicalagin thus could be explored further as a potent candidate compound in the treatment of AS.

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Section: Discussionmentioning

confidence: 99%

“…Several plant-derived compounds have been shown to possess neuroprotective effects [ 5 , 23 , 24 ]. Punicalagin (2,3-hexahydroxydiphenoyl-gallagyl-D-glucose) is an ellagitannin and is the major bioactive polyphenol widely present in pomegranates.…”

Section: Introductionmentioning

confidence: 99%

Punicalagin Exerts Protective Effects against Ankylosing Spondylitis by Regulating NF-κB-TH17/JAK2/STAT3 Signaling and Oxidative Stress

Feng

Yang

Wang

et al. 2020

BioMed Research International

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“…NG is a naturally occurring phytochemical commonly found in grapefruit juice with a number of health benefits [41]. It has been much explored by different research groups for its capability to ameliorate hazardous effects of various metals [42] as well as in different pathological conditions [43][44][45]. NG has been reported to mitigate cisplatin-induced OxiS and inflammatory response.…”

Section: Studies On Ameliorative Nature Of Ng Against Oxismentioning

confidence: 99%

“…Oral administration of NG (10, 20, and 40 mg/kg) to isoproterenol exposed Wistar rats showed a considerable decrease in the levels of lipid peroxidation products and improved the antioxidant status [47]. NG is known for its anti-inflammatory [46,[48][49][50] and antioxidative nature [43,45,51,52]. Arsenic-induced hepatic and renal toxicity are reported to be reduced by anti-inflammatory and antioxidative nature of NG [53].…”

Section: Studies On Ameliorative Nature Of Ng Against Oxismentioning

confidence: 99%

Naringin Reveals Ameliorative Property Over Elevated Oxidative Stress Levels in Animal Models

Singh¹,

Kaur²,

Sharma³

2018

Asian J Pharm Clin Res

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Oxidative stress (OxiS) has been implicated in the pathogenesis of many diseases. Free radicals interact with different cell components including DNA, proteins, and lipids to become stable. In this process, these free radicals damage the integrity of these biological moieties and result in various health implications. Naringin (NG), a naturally occurring phytochemical commonly found in grapefruit juice has been explored for its protective role against OxiS. In this short review paper, an attempt has been made to compile the study reports revealing the antioxidative nature of NG in different animal models. Studies have reported NG as a potential antioxidant in various health ailments including diabetes, cardiac fibrosis, cognitive dysfunction, and neurodegeneration.

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“…Naringin was used in a recent study that involved a mouse model of ankylosis spondylitis. Analysis of harvested tissues showed that flavonoid intraperitoneal administration attenuated the expression of proinflammatory cytokines [such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6] and inhibited the production of signal transducer and activator of transcription (STAT)3 and Janus kinase (JAK)2 (implicated in the sensitivity to this disease) in a dose-dependent manner[52]. In parallel, naringin also improved oxidative stress markers in treated mice by restoring the activity of superoxide dismutase, catalase and glutathione peroxidase in vivo.…”

mentioning

confidence: 99%

Bioinspired bone therapies using naringin: applications and advances

Lavrador

Gaspar

Mano

2018

Drug Discovery Today

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The use of natural compounds for treating chronic bone diseases holds remarkable potential. Among these therapeutics, naringin, a flavanone glycoside, represents one of the most promising candidates owing to its multifaceted effect on bone tissues. This review provides an up-to-date overview on naringin applications in the treatment of bone disorders, such as osteoporosis and osteoarthritis, and further highlights its potential for stem cell pro-osteogenic differentiation therapies. A critical perspective on naringin clinical translation is also provided. The topic is discussed in light of recently developed biomaterial-based approaches that potentiate its bioavailability and bioactivity. Overall, the reported pro-osteogenic, antiresorptive and antiadipogenic properties establish this flavanone as an exciting candidate for application in bone tissue engineering and regenerative medicine.

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Protective effect of naringin against ankylosing spondylitis via ossification, inflammation and oxidative stress in mice

Cited by 18 publications

References 35 publications

Punicalagin Exerts Protective Effects against Ankylosing Spondylitis by Regulating NF-κB-TH17/JAK2/STAT3 Signaling and Oxidative Stress

Punicalagin Exerts Protective Effects against Ankylosing Spondylitis by Regulating NF-κB-TH17/JAK2/STAT3 Signaling and Oxidative Stress

Naringin Reveals Ameliorative Property Over Elevated Oxidative Stress Levels in Animal Models

Bioinspired bone therapies using naringin: applications and advances

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