Protective Effect of Montelukast, a Cysteinyl Leukotriene Receptor-1 Antagonist, against Intestinal Ischemia-Reperfusion Injury in the Rat

Duran, Arif; Otiük, H; Eh, Terzi; Tosun, Mehmet; Oziiü, H; Ocak, Tarık; Kiiüer, A

doi:10.1080/00015458.2013.11680954

Cited by 9 publications

(5 citation statements)

References 31 publications

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“…15–17 Additionally, animal studies show that montelukast has a beneficial effect on oxidative stress-mediated conditions, such as ischemia-reperfusion injury, drug intoxication, and lipopolysaccharide-induced oxidative stress. 18–21 Al Saadi reports that montelukast decreases ROS production in whole blood and isolates human polymorphonuclear neutrophils in asthmatic children. 22 However, our recent study showed that montelukast monotherapy does not overcome the oxidative stress produced by asthma in children.…”

Section: Discussionmentioning

confidence: 99%

Plasma total thiol pool in children with asthma: Modulation during montelukast monotherapy

Dilek

Özkaya

Koçyiğit

et al. 2015

Int J Immunopathol Pharmacol

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Background: Inflammation, which is a hallmark of asthma, is one of the main sources of oxidative stress in the human body. Thiols are powerful antioxidants that protect cells against the consequences of oxidative stress. We aimed to investigate whether asthma and montelukast monotherapy affect the total plasma thiol pool in children. Methods: A total of 60 children with asthma and 35 healthy controls participated in the study. Group I consisted of newly diagnosed asthmatics who did not have regular anti-asthmatic therapy previously. Group II consisted of patients who had been undertaking montelukast monotherapy regularly for at least 4 months. Plasma total antioxidant status (TAS) and plasma total thiol (PTT) were measured using spectrophotometric methods. In addition, the median TAS and PTT levels for groups I and II were not statistically different (P >0.05). There was a positive correlation between TAS and PTT levels (rho = 0.38, P <0.05) in group I. Conclusion: In order to balance the oxidative stress, both TAS and PTT which are markers of the antioxidant system are reduced in children with asthma. Montelukast monotherapy can limit oxidative stress and thus restore PTT levels but not TAS levels in asthmatic children.

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Section: Discussionmentioning

confidence: 99%

Plasma total thiol pool in children with asthma: Modulation during montelukast monotherapy

Dilek

Özkaya

Koçyiğit

et al. 2015

Int J Immunopathol Pharmacol

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“…GSH has been used to indicate antioxidant systems in evaluating various substances in such an ischemia/reperfusion model. [ 27 ] As in the study of Buetler et al, increased GSH levels were elevated as a defense mechanism against increased free oxygen radicals. [ 10 ]…”

Section: Discussionmentioning

confidence: 94%

Is the increased ozone dosage key factor for its antiinflammatory effect in an experimental model of mesenteric ischemia?

Erginel

2023

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Ischemia/reperfusion injury of the intestines is a severe surgical condition. This study aimed to reveal ozone therapy effects with relatively increased ozone dosage in a created ischemia/reperfusion injury model. METHODS: In this study, 24 albino Wistar rats were examined in three groups. Rats in the control group (CG, n=8) underwent only a laparotomy. In the sham group (SG, n=8) and ozone group (OG, n=8), the superior mesenteric artery (SMA) of the rats was occluded for 1 h. After de-occluding the SMA, the abdomen was closed, physiological saline was infused intraperitoneally in the SG, and an increased ozone/oxygen mixture dose (from 0.7 mg/kg to 1 mg/kg) was infused intraperitoneally in the OG. Small intestine samples were obtained at the 24th h for histopathological examination of intestinal mucosal injury and evaluated according to the Chiu score. In addition, Malondialdehyde and Myeloperoxidase levels were evaluated for oxidant levels, whereas, Glutathione (GSH) enzyme activity was measured to evaluate the tissue antioxidant system. RESULTS: Histopathologically, the Chiu score was the lowest in the CG. It was lower in the OG compared to the SG showing the ameliorating effect of ozone on the intestinal mucosa. Chiu score in the OG was higher compared to that in the CG, but not statistically significant. A significantly higher GSH level was observed in the OG compared to the SG, proving antioxidant activity. CONCLUSION: In this experimental model of ischemia/reperfusion in rats, treatment with an increased ozone level decreased the inflammatory process through antioxidant mechanisms and reduced intestinal mucosal damage. However, the effectiveness of ozone therapy depends on its dosages.

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“…In fact, the tight correlation between the decreases of intestinal GSH content and the duration of ischemia only 5 min after the initiation of reperfusion (Figure 3) provides a very interesting clue to the role of this cellular antioxidant during intestinal I/R. Other authors have reported significant decreases in intestinal GSH after 30 min ischemia and 45 min reperfusion of only 18% of the control value [17], or a 30 % reduction in total antioxidant capacity (GSH is part of this capacity) after 1 h of ischemia followed by 2 h of reperfusion [18], or have only measured the blood GSH concentration without caring about the concentration in cecum [19]. As can be interpreted by the data herein, the modifications of intestinal GSH content occurred immediately after initiating reperfusion (as soon as 5 min) and were proportional to the duration of ischemia.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Intestinal Ischemia/Reperfusion-Induced Decrease of Intestinal Glutathione

Ferri

Prieto‐Moure

et al. 2017

ROS

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Intestinal ischemia followed by reperfusion has been widely studied, and oxidative stress generated by the production of reactive oxygen species is one major pathophysiological mechanism involved. The reduced form of glutathione (GSH) as part of the cellular antioxidant defense is affected during this process. The aim of this study was to perform a systematic study on the time course of intestinal GSH during intestinal ischemia, and ischemia followed by reperfusion (I/R) to clarify its role in I/R. Wistar rats were subject to laparotomy and ischemia achieved by clamping the intestinal vascular axis, and releasing the elastic band for the reperfusion period. Ischemia and I/R were monitored by surface oxygen and carbon dioxide electrodes. GSH was assayed by high pressure liquid chromatography. Our results showed that ischemia induced slight decreases in cecal GSH that could not be established as significant in the 120 min ischemia group. However, 5 and 30 min of reperfusion following different times of ischemia promoted a time-dependent decrease of GSH that reached 30% of control values. In conclusion, intestinal GSH may play a critical role during I/R in view of the correlation between its concentration after revascularization and the time of ischemia, which deserves further investigation.

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Protective Effect of Montelukast, a Cysteinyl Leukotriene Receptor-1 Antagonist, against Intestinal Ischemia-Reperfusion Injury in the Rat

Cited by 9 publications

References 31 publications

Plasma total thiol pool in children with asthma: Modulation during montelukast monotherapy

Plasma total thiol pool in children with asthma: Modulation during montelukast monotherapy

Is the increased ozone dosage key factor for its antiinflammatory effect in an experimental model of mesenteric ischemia?

Characterization of Intestinal Ischemia/Reperfusion-Induced Decrease of Intestinal Glutathione

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