Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level

Purnaningsih, Dyah; Djawad, Khairuddin; Wahab, Siswanto; Massi, Nasrum; Alam, Gemini; Bahar, Burhanuddin

doi:10.5455/ijmrcr.mangosteen-skin-extract-dmba

Cited by 1 publication

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Non-melanoma skin cancer is also ranked as the fifth most common cancer worldwide by the World Health Organization (WHO) (Khazaei et al, 2019). Meanwhile, the incidence of melanoma is increasing at a faster rate than any other cancer with worrying mortality rates (Purnaningsih et al, 2018;Khazaei et al, 2019). UV radiation in particular has been strongly associated with skin carcinogenesis, causing oxidative damage, pro-inflammatory responses and DNA mutations (Hiraku et al, 2007;Kapadia et al, 2013;Im et al, 2017).…”

Section: Skin Cancer and Melanomamentioning

confidence: 99%

“…Hence, xanthones were highlighted to be photoprotective and chemopreventive agents. A recent study by Purnaningsih et al (2018) demonstrated the chemopreventive activity of topical applications of 100, 200 and 400 ppm of mangosteen skin (G. mangostana L.) ethanol extracts which predominantly consists of 2, 3 and 5 using a DMBA-induced mice skin cancer model. The authors hypothesized that the observed chemopreventive effect of the extract came from the antioxidant activity and attenuation of ROS production by 2, 3 and 5 (Purnaningsih et al, 2018).…”

Section: Photoprotective Activity Of Xanthones For Chemopreventionmentioning

confidence: 99%

“…A recent study by Purnaningsih et al (2018) demonstrated the chemopreventive activity of topical applications of 100, 200 and 400 ppm of mangosteen skin (G. mangostana L.) ethanol extracts which predominantly consists of 2, 3 and 5 using a DMBA-induced mice skin cancer model. The authors hypothesized that the observed chemopreventive effect of the extract came from the antioxidant activity and attenuation of ROS production by 2, 3 and 5 (Purnaningsih et al, 2018). This hypothesis was also consolidated by previous studies that showed 2 isolated from G. mangostana L. pericarps to exhibit antioxidative activity by increasing the antioxidant activity of SOD and CAT, halting the generation of oxidative stress (Im et al, 2017).…”

Section: Photoprotective Activity Of Xanthones For Chemopreventionmentioning

confidence: 99%

“…Furthermore, plants of the genera Calophyllum, Cratoxylum, Garcinia, Gentiana, Hypericum and Swertia were proposed to possess great developmental prospect due to their rich content of xanthones (Ruan et al, 2017). This class of compounds possess a wide range of biological activities including antiinflammatory (Teh et al, 2017;Mah et al, 2019;Aye et al, 2020;Ng et al, 2020), antioxidant (Wang et al, 2018a), antimicrobial (Koh et al, 2013;Auranwiwat et al, 2014), chemotherapeutic (Beninati et al, 2014) and chemopreventive (Purnaningsih et al, 2018) activities. Thus, xanthones are promising lead compounds for treating skin inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Natural Xanthones and Skin Inflammatory Diseases: Multitargeting Mechanisms of Action and Potential Application

et al. 2020

View full text Add to dashboard Cite

The pathogenesis of skin inflammatory diseases such as atopic dermatitis, acne, psoriasis, and skin cancers generally involve the generation of oxidative stress and chronic inflammation. Exposure of the skin to external aggressors such as ultraviolet (UV) radiation and xenobiotics induces the generation of reactive oxygen species (ROS) which subsequently activates immune responses and causes immunological aberrations. Hence, antioxidant and anti-inflammatory agents were considered to be potential compounds to treat skin inflammatory diseases. A prime example of such compounds is xanthone (xanthene-9-one), a class of natural compounds that possess a wide range of biological activities including antioxidant, anti-inflammatory, antimicrobial, cytotoxic, and chemotherapeutic effects. Many studies reported various mechanisms of action by xanthones for the treatment of skin inflammatory diseases. These mechanisms of action commonly involve the modulation of various pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor α (TNF-α), as well as anti-inflammatory cytokines such as IL-10. Other mechanisms of action include the regulation of NF-κB and MAPK signaling pathways, besides immune cell recruitment via modulation of chemokines, activation, and infiltration. Moreover, disease-specific activity contributed by xanthones, such as antibacterial action against Propionibacterium acnes and Staphylococcus epidermidis for acne treatment, and numerous cytotoxic mechanisms involving pro-apoptotic and anti-metastatic effects for skin cancer treatment have been extensively elucidated. Furthermore, xanthones have been reported to modulate pathways responsible for mediating oxidative stress and inflammation such as PPAR, nuclear factor erythroid 2-related factor and prostaglandin cascades. These pathways were also implicated in skin inflammatory diseases. Xanthones including the prenylated α-mangostin (2) and γ-mangostin (3), glucosylated mangiferin (4) and the caged xanthone gambogic acid (8) are potential lead compounds to be further developed into pharmaceutical agents for the treatment of skin inflammatory diseases. Future studies on the structure-activity relationships, molecular mechanisms, and applications of xanthones for the treatment of skin inflammatory diseases are thus highly recommended.

show abstract

Section: Skin Cancer and Melanomamentioning

confidence: 99%

Section: Photoprotective Activity Of Xanthones For Chemopreventionmentioning

confidence: 99%

Section: Photoprotective Activity Of Xanthones For Chemopreventionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Natural Xanthones and Skin Inflammatory Diseases: Multitargeting Mechanisms of Action and Potential Application

et al. 2020

View full text Add to dashboard Cite

show abstract

Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level

Cited by 1 publication

References 0 publications

Natural Xanthones and Skin Inflammatory Diseases: Multitargeting Mechanisms of Action and Potential Application

Natural Xanthones and Skin Inflammatory Diseases: Multitargeting Mechanisms of Action and Potential Application

Contact Info

Product

Resources

About