Protective Effect of Luminal Uric Acid Against Indomethacin-Induced Enteropathy: Role of Antioxidant Effect and Gut Microbiota

Wada, Akinori; Higashiyama, Masaaki; Kurihara, Chie; Ito, Suguru; Tanemoto, Rina; Mizoguchi, Akinori; Nishii, Shin; Inaba, Kenichi; Sugihara, Nao; Hanawa, Yoshinori; Horiuchi, Kazuki; Shibuya, Naoki; Akiyama, Misaki; Okada, Yoshikiyo; Watanabe, Chikako; Komoto, Shunsuke; Tomita, Kengo; Takei, Fumie; Hokari, Ryota

doi:10.1007/s10620-021-06848-z

Cited by 12 publications

(17 citation statements)

References 52 publications

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“…It is known that UA may play an anti-inflammatory and antioxidant role. 8 Future studies with a large number of pAPS are desired to confirm the present data.…”

supporting

confidence: 63%

Uric acid levels in primary antiphospholipid syndrome

Carvalho

Shoenfeld

2021

Lupus

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“…It is known that UA may play an anti-inflammatory and antioxidant role. 8 Future studies with a large number of pAPS are desired to confirm the present data.…”

supporting

confidence: 63%

Uric acid levels in primary antiphospholipid syndrome

Carvalho

Shoenfeld

2021

Lupus

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“…In actually, lower serum uric acid levels are not better. The antioxidant effect of uric acid is protective on the nervous system, intestinal tract, and kidney ( 36 – 38 ). Some researchers have demonstrated that low uric acid levels are associated with an increased risk of mortality in patients ( 39 , 40 ).…”

Section: Discussionmentioning

confidence: 99%

The dose-response relationship between sex hormones and hyperuricemia in different gender: NHANES 2013-2016

Qian²,

Ma³

et al. 2022

Front. Endocrinol.

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ObjectivesTo access the dose-response relationship between sex hormones and hyperuricemia (HUA), and to find the cut-off value in different gender.Methods9,685 participants were derived from the database of National Health and Nutrition Examination Survey (NHANES). Restricted cubic spline (RCS) analysis were applied to explore the relationship between sex hormones and HUA after adjusting for confounding factors by propensity score match (PSM). Logistic regression was used to estimate the odds ratio (OR) and 95% CI.ResultsThe prevalence of HUA was 15.13% in female participants and 22.30% in male participants. Logistic regression analysis showed that estradiol (E2) was independently associated with HUA for a P value of 0.003 and 0.01in female and male participants, respectively. Testosterone (T) was only independently associated with HUA in male participants (P<0.001) but not in female participants (P = 0.59). RCS analysis showed a dose-response relationship between sex hormones and HUA. The risk of HUA increased as E2 lower than 29.6pg/mL in female participants and T lower than 389.1ng/dL in male participants. E2 higher than 23.6pg/ml was an independent risk factor for HUA in male participants.ConclusionA dose-response relationship was found between sex hormones and HUA. The cut-off value of E2 in male and female participants was 29.6pg/mL and 23.6pg/mL, respectively, and the cut-off value of T in male participants was 389.1ng/dL. These results provide a reference for preventing HUA and hormone supplement therapy.

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“…So, we suspected that the obtained purine-reducing result of Q201E has been discounted due to the component complexity of the fish sauce system. In addition, 1/3 of uric acid in the human body is metabolized through the intestine, and uric acid cannot enter the blood through the rat intestine ( Bronk and Shaw, 1986 , Yasujima et al, 2018 ), oral administration of uric acid in mice did not cause an increase in plasma uric acid even had a protective effect against indomethacin induced intestinal injury in mice ( Wada et al, 2022 , Yasutake et al, 2017 ). And it has been reported that the effect of oral hypoxanthine on blood uric acid in the subjects is higher than that of xanthine ( Clifford, Riumallo, Young, & Scrimshaw, 1976 ), so we believe that the effect of uric acid in food on the human body is less than that of hypoxanthine and purine precursors.…”

Section: Discussionmentioning

confidence: 99%