Protective effect of flavonoids on drug-induced hepatotoxicity in vitro

Study of Leukopenia Induced by a High Dose of Cyclophosphamide in Mice

“…The elevation of AST and ALT in our present findings is consistent with [22]. The liver is the richest source of both AST and ALT enzymes and, thus, the levels of both these enzymes are expected to increase as a result of damage to the liver cells [23]. That related to chemical-induced tissue injury along with hepatocellular necrosis [24].…”

Study of Leukopenia Induced by a High Dose of Cyclophosphamide in Mice

“…The elevation of AST and ALT in our present findings is consistent with [22]. The liver is the richest source of both AST and ALT enzymes and, thus, the levels of both these enzymes are expected to increase as a result of damage to the liver cells [23]. That related to chemical-induced tissue injury along with hepatocellular necrosis [24].…”

Protective Effects of Β-Glucan and G-CSF on the Physiological Alterations Induced by Cyclophosphamide in Mice

“…It is reported that CTX can alter liver functions by modulating all liver enzymes. The liver is the richest source of both AST and ALTenzymes [20].And thus, the levels of both these enzymes are expected to increase as result of damage to the liver cells [21]. In support of these reports, our data indicate that CTX treatment resulted in a significant increase in the activities of AST and ALT in sera as compared to the control group.…”

Free radical scavenging and hepatoprotective activity of jigrine against galactosamine induced hepatopathy in rats

“…Pre-treatment of the rats with jigrine significantly reduced the elevated levels of TBARS and increased the concentration of GSH. These results suggest that the hepatoprotective action of jigrine might be due to the presence of antioxidants like flavonoids, Vitamin A, Vitamin C and ␣-and ␤-carotenes (Davila et al, 1989;Toshiyuki et al, 1992). These antioxidants are present in the plant ingredients of jigrine, e.g.…”

Study of Leukopenia Induced by a High Dose of Cyclophosphamide in Mice

“…The elevation of AST and ALT in our present findings is consistent with [22]. The liver is the richest source of both AST and ALT enzymes and, thus, the levels of both these enzymes are expected to increase as a result of damage to the liver cells [23]. That related to chemical-induced tissue injury along with hepatocellular necrosis [24].…”

Protective Effects of Β-Glucan and G-CSF on the Physiological Alterations Induced by Cyclophosphamide in Mice

“…It is reported that CTX can alter liver functions by modulating all liver enzymes. The liver is the richest source of both AST and ALTenzymes [20].And thus, the levels of both these enzymes are expected to increase as result of damage to the liver cells [21]. In support of these reports, our data indicate that CTX treatment resulted in a significant increase in the activities of AST and ALT in sera as compared to the control group.…”

Free radical scavenging and hepatoprotective activity of jigrine against galactosamine induced hepatopathy in rats

“…Pre-treatment of the rats with jigrine significantly reduced the elevated levels of TBARS and increased the concentration of GSH. These results suggest that the hepatoprotective action of jigrine might be due to the presence of antioxidants like flavonoids, Vitamin A, Vitamin C and ␣-and ␤-carotenes (Davila et al, 1989;Toshiyuki et al, 1992). These antioxidants are present in the plant ingredients of jigrine, e.g.…”

Study of Leukopenia Induced by a High Dose of Cyclophosphamide in Mice

“…The elevation of AST and ALT in our present findings is consistent with [22]. The liver is the richest source of both AST and ALT enzymes and, thus, the levels of both these enzymes are expected to increase as a result of damage to the liver cells [23]. That related to chemical-induced tissue injury along with hepatocellular necrosis [24].…”

Protective Effects of Β-Glucan and G-CSF on the Physiological Alterations Induced by Cyclophosphamide in Mice

“…It is reported that CTX can alter liver functions by modulating all liver enzymes. The liver is the richest source of both AST and ALTenzymes [20].And thus, the levels of both these enzymes are expected to increase as result of damage to the liver cells [21]. In support of these reports, our data indicate that CTX treatment resulted in a significant increase in the activities of AST and ALT in sera as compared to the control group.…”

Free radical scavenging and hepatoprotective activity of jigrine against galactosamine induced hepatopathy in rats

“…Pre-treatment of the rats with jigrine significantly reduced the elevated levels of TBARS and increased the concentration of GSH. These results suggest that the hepatoprotective action of jigrine might be due to the presence of antioxidants like flavonoids, Vitamin A, Vitamin C and ␣-and ␤-carotenes (Davila et al, 1989;Toshiyuki et al, 1992). These antioxidants are present in the plant ingredients of jigrine, e.g.…”