volume 93, issue 0, P2-P-215 2020
DOI: 10.1254/jpssuppl.93.0_2-p-215
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Abstract: Age-related visual impairments can occur even in the absence of recognized eye diseases. Retinal ganglion cells (RGCs) are neurons that transmit visual information from the retina to the brain and are more vulnerable to agerelated loss than other retinal neurons. Recently, it has been reported that deficiency of apelin, an endogenous peptide ligand of the G protein-coupled receptor APJ, enhances several tissues aging. In the present study, we investigated the effect of the apelin-APJ system against the loss of…

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