Protective effect of diphlorethohydroxycarmalol isolated from Ishige okamurae against high glucose-induced-oxidative stress in human umbilical vein endothelial cells

Heo, Soo‐Jin; Hwang, Ji-Young; Choi, Jung-In; Lee, Seung‐Hong; Park, Pyo-Jam; Kang, Do‐Hyung; Oh, Chulhong; Kim, Dongwoo; Han, Ji-Sook; Jeon, You‐Jin; Kim, Hak-Ju; Choi, Il‐Whan

doi:10.1016/j.fct.2010.02.025

Cited by 50 publications

(31 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many researchers have reported that the protective effect of natural products against high glucose caused oxidative stress was affected by their antioxidant effects (Li et al, 2011;Qian, Huo, Wang, & Qian, 2011). Among the candidates, fucoxanthin has attracted extensive interest due to its excellent biological activities including anticancer, anti-inflammation, antioxidant and anti-angiogenic activity (Fung, Hamid, & Lu, 2013;Heo et al, 2010a;Kim et al, 2013;Sugawara, Matsubara, Akagi, Mori, & Hirata, 2006). Especially, several evidences have demonstrated that fucoxanthin shows improvement of metabolic disease such as diabetes, obesity and hepatic lipid metabolism (Hosokawa et al, 2010;Hu et al, 2012;Maeda et al, 2005;Woo et al, 2010).…”

Section: Discussionmentioning

confidence: 98%

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Kang

Lee

et al. 2014

Journal of Functional Foods

Self Cite

View full text Add to dashboard Cite

Available online A B S T R A C THigh glucose induced oxidative stress is implicated in intracellular toxicity in tissue and blood vessel such as oxidative stress, lipid peroxidation, and cell death. In this study, we attempted to investigate protective effects of fucoxanthin isolated from Ishige okamurae against high glucose induced oxidative stress in human umbilical vein endothelial cells (HUVEC) and zebrafish model. The ROS generation, lipid peroxidation and cell death were significantly reduced in both the fucoxanthin treated HUVEC and zebrafish in vivo model, compared to those of both negative controls. This study indicates that fucoxanthin could protect cells and organ injury against oxidative stress induced by high glucose in vitro HUVEC and in vivo zebrafish model.

show abstract

Section: Discussionmentioning

confidence: 98%

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Kang

Lee

et al. 2014

Journal of Functional Foods

Self Cite

View full text Add to dashboard Cite

show abstract

“…DPHC is a marine algal polyphenol that consists of four phloroglucinol units and functional hydroxyl groups. Several studies report that phloroglucinol derivatives have ROS scavenging effect and protective effect against oxidative stress-induced cell damage [11,[13][14][15][16]19]. However, there are no reports regarding DPHC in terms of its neuroprotective effects.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, we investigated the protective effect of DPHC on oxidative stress-induced melanogenesis and diabetes [11,16]. However, the direct effect of DPHC on the neuroprotective efficacy has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

“…Phlorotannins, a kind of polyphenolic compound, are one of the most common classes of secondary metabolites in marine algae. It consists of phloroglucinol units linked to each other in various ways and is of wide occurrence amongst brown and red algae [11]. Several studies have pointed out the variety of biological functions of phlorotannins including anticoagulant, antidiabetic, antifungal, anti-inflammatory, and anti-cancer activities [11][12][13], and we specially focus on the antioxidant potential as scavengers of reactive oxygen species (ROS) induced by oxidative stress in biological systems.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neuroprotective Effect of Phlorotannin Isolated from Ishige okamurae Against H2O2-Induced Oxidative Stress in Murine Hippocampal Neuronal Cells, HT22

Heo

Cha

Kim

et al. 2012

Appl Biochem Biotechnol

Self Cite

View full text Add to dashboard Cite

The present study is designed to investigate the neuroprotective effect of a kind of phlorotannins, diphlorethohydroxycarmalol (DPHC) isolated from Ishige okamurae against hydrogen peroxide (H(2)O(2))-induced oxidative stress in murine hippocampal neuronal cells, HT22. H(2)O(2) treatment induced neurotoxicity, whereas DPHC prevented cells from H(2)O(2)-induced damage then restoring cell viability was significantly increased. DPHC slightly reduced the expression of Bax induced by H(2)O(2) but recovered the expression of Bcl-xL as well as caspase-9 and -3 mediated PARP cleavage by H(2)O(2). Intracellular reactive oxygen species (ROS) and lipid peroxidation was overproduced as the result of the addition of H(2)O(2); however, these ROS generations and lipid peroxidation were effectively inhibited by addition of DPHC in a dose-dependent manner. Moreover, DPHC suppressed the elevation of H(2)O(2)-induced Ca(2+) release. These findings indicate that DPHC has neuroprotective effects against H(2)O(2)-induced damage in neuronal cells, and that an inhibitory effect on ROS production may contribute to the underlying mechanisms.

show abstract

“…Inflammation is the first response of the immune system to infection and plays a pivotal role in many diseases , Heo et al 2010a, 2010b. NO is one of the major factors relevant to inflammationin macrophages and is generated from L-arginine by NO synthase, a three-member enzyme family that includes iNOS (Park et al 2011).…”

Section: Effect Of Cje On Lps-induced Mapks Activationmentioning

confidence: 99%

Anti-inflammatory effect of polyphenol-rich extract from the red alga Callophyllis japonica in lipopolysaccharide-induced RAW 264.7 macrophages

Ryu¹,

Choi²,

Qian³

et al. 2014

ALGAE

Self Cite

View full text Add to dashboard Cite

Despite the extensive literature on marine algae over the past few decades, a paucity of published research and studies exists on red algae. The purpose of this study was to evaluate the potential therapeutic properties of the ethanol extract of the red alga Callophyllis japonica against lipopolysaccharide (LPS)-stimulated macrophage inflammation. The C. japonica extract (CJE) significantly inhibited the nitric oxide (NO) production and the induced dose-dependent reduction of the protein and mRNA levels of inducible nitric oxide synthase and cyclooxygenase-2. Additionally, the CJE reduced the mRNA levels of inflammatory cytokines, including tumor necrosis factor-α, interleukin (IL)-1β, and IL-6. We investigated the mechanism by which the CJE inhibits NO by examining the level of mitogen-activated protein kinases (MAPKs) activation, which is an inflammation-induced signaling pathway in macrophages. The CJE significantly suppressed the LPS-induced phosphorylation of c-Jun N-terminal kinase, extracellular signal-regulated kinase and p38 MAPK. Taken together, the results of this study demonstrate that the CJE inhibits LPS-induced inflammation by blocking the MAPK pathway in macrophages.

show abstract

Protective effect of diphlorethohydroxycarmalol isolated from Ishige okamurae against high glucose-induced-oxidative stress in human umbilical vein endothelial cells

Cited by 50 publications

References 44 publications

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Neuroprotective Effect of Phlorotannin Isolated from Ishige okamurae Against H2O2-Induced Oxidative Stress in Murine Hippocampal Neuronal Cells, HT22

Anti-inflammatory effect of polyphenol-rich extract from the red alga Callophyllis japonica in lipopolysaccharide-induced RAW 264.7 macrophages

Contact Info

Product

Resources

About