Protective effect of Crocin against zearalenone-induced oxidative stress in liver and kidney of Balb/c mice

Salem, Intidhar Ben; Boussabbeh, Manel; Helali, Sabeh; Abid‐Essefi, Salwa; Bacha, Hassen

doi:10.1007/s11356-015-5086-2

Cited by 28 publications

(13 citation statements)

References 56 publications

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“…(2012b) found feeding diets with ZEA (200 to 800 μg/kg) to weanling gilts decreased SOD and increased MDA in serum, while the addition of montmorillonite clay alleviated these adverse effects induced by ZEA. In the present study, significant interactions between toxins and MBA was observed in the serum antioxidant indices of pregnant gilts, besides, the addition of MBA counteracted the negative effects of ZEA on the antioxidant indices, suggesting that the disadvantageous effects of ZEA and the advantageous effects of MBA might be associated with the length of feeding period, the physiological status of animals, and even animal species and age ( Ben et al., 2015 ; Ren et al., 2016 ).…”

Section: Discussionsupporting

confidence: 53%

Bacillus subtilis ANSB01G culture alleviates oxidative stress and cell apoptosis induced by dietary zearalenone in first-parity gestation sows

Zhou

Lei

et al. 2020

Animal Nutrition

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This study was conducted to evaluate the alleviation of Bacillus subtilis ANSB01G culture as zearalenone (ZEA) biodegradation agent on oxidative stress, cell apoptosis and fecal ZEA residue in the first parity gestation sows during the gestation. A total of 80 first-parity gilts (Yorkshire × Landrace) were randomly allocated to 4 dietary treatments with 20 replications per treatment and one gilt per replicate. The dietary treatments were as follows: CO (positive control); MO (negative control, ZEA level at 246 μg/kg diet); COA (CO + B. subtilis ANSB01G culture with 2 × 10 9 CFU/kg diet); MOA (MO + ZEA level at 260 μg/kg diet + B. subtilis ANSB01G culture with 2 × 10 9 CFU/kg diet). The experiment lasted for the whole gestation period of sows. Results showed that feeding the diet naturally contaminated with low-dose ZEA caused an increase of cell apoptosis in organ and the residual ZEA in feces as well as a decrease of antioxidant function in serum. The addition of B. subtilis ANSB01G culture in the diets can effectively alleviate the status of oxidative stress and cell apoptosis induced by ZEA in diets of gestation sows, as well as decrease the content of residual ZEA in feces.

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Section: Discussionsupporting

confidence: 53%

Bacillus subtilis ANSB01G culture alleviates oxidative stress and cell apoptosis induced by dietary zearalenone in first-parity gestation sows

Zhou

Lei

et al. 2020

Animal Nutrition

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“…A great attention has been paid to the oxidative stress induced by Fusaria mycotoxins in the last decades. For example, dietary ZEA induced serious oxidative injuries in both renal and hepatic tissues in mice via adverse impact upon the level of the MDA, and the activities of CAT and SOD [ 37 ]. GSH-Px and SOD are the key antioxidant enzymes that can scavenge ROS generated from oxidant stress.…”

Section: Resultsmentioning

confidence: 99%

Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts

Shi

Zhou

Zhao

et al. 2018

J Animal Sci Biotechnol

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BackgroundThe current study was carried out to evaluate the effects of mycotoxin biodegradation agent (MBA, composed of Bacillus subtilis ANSB01G and Devosia sp. ANSB714) on relieving zearalenone (ZEA) and deoxynivalenol (DON) toxicosis in immature gilts.MethodsA total of forty pre-pubertal female gilts (61.42 ± 1.18 kg) were randomly allocated to four diet treatments: CO (positive control); MO (negative control, ZEA 596.86 μg/kg feed and DON 796 μg/kg feed); COA (CO + 2 g MBA/kg feed); MOA (MO + 2 g MBA/kg feed). Each treatment contained 10 replicates with 1 gilt per replicate. Gilts were housed in an environmentally controlled room with the partially slatted floor.ResultsDuring the entire experimental period of 28 d, average daily gain (ADG) and average daily feed intake (ADFI) of gilts in MO group was significantly reduced compared with those in CO group. The vulva size of gilts was significantly higher in MO group than CO group. In addition, significant increases in the plasma levels of IgA, IgG, IL-8, IL-10 and PRL were determined in MO group compared with that in CO group. ZEA and DON in the diet up-regulated apoptotic caspase-3 in ovaries and uteri, along with down-regulated the anti-apoptotic protein Bcl-2 in ovaries. The supplementation of MBA into diets co-contaminated with ZEA and DON significantly increased ADG, decreased the vulva sizes, reduced the levels of IgG, IL-8 and PRL in plasma, and regulated apoptosis in ovaries and uteri of gilts.ConclusionsThe present results indicated that feeding diet contaminated with ZEA and DON simultaneously (596.86 μg/kg + 796 μg/kg) had detrimental effects on growth performance, plasma immune function and reproductive status of gilts. And MBA could reduce the negative impacts of these two toxins, believed as a promising feed additive for mitigating toxicosis of ZEA and DON at low levels in gilts.

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“…Previous studies have reported that the administration of ZEN (10–30 mg/kg BW) for 4 weeks resulted in serum hormone changes and organ damage in mice [ 43 , 51 , 52 ]. In this study, all mice were free to eat and drink.…”

Section: Methodsmentioning

confidence: 99%

The Protective Role of Bacillus velezensis A2 on the Biochemical and Hepatic Toxicity of Zearalenone in Mice

Wang

et al. 2018

Toxins

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Zearalenone (ZEN) is an estrogen-like mycotoxin produced by Fusarium that seriously compromises the safety of animal and human health. In this study, our aim was to evaluate the protective effect of Bacillus velezensis A2 against biochemical and pathological changes induced by zearalenone in mice. Kunming mice (n = 40; 25 ± 2 g) were allotted to four treatment groups: a control group (basic feed); a ZEN group (basic feed with a ZEN dose of 60 mg/kg); an A2 strain fermented feed group (150 g of feed mixed with 150 mL of sterile distilled water and inoculated with 5 mL of phosphate buffer salt (PBS) resuspended A2 strain); and an A2 strain fermented ZEN-contaminated feed group. (A2 strain group 150 mL pure bacterial distilled water system mixed with 150 g ZEN-contaminated feed.) Our results showed that the Bacillus velezensis A2 strain can completely degrade the ZEN-contaminated feed within 5 days. (The concentration of ZEN in fermentation was 60 μg/mL.) After the mice fed for 28 days, compared with the control group, the activities of AST and ALT were increased, the activities of glutathione peroxidase (GSH-PX) and total superoxide dismutase (T-SOD) were decreased, and the amount of creatinine (CRE), blood urea nitrogen (BUN), uric acid (UA), and malondialdehyde (MDA) in the ZEN group were increased in the mice serum (p < 0.05; p < 0.01). However, compared with the ZEN group, these biochemical levels were reversed in the A2 strain fermented feed group and in the A2 strain fermented ZEN-contaminated feed group (p < 0.05; p < 0.01). Furthermore, histopathological analysis only showed pathological changes of the mice liver in the ZEN group. The results showed that Bacillus velezensis A2 as additive could effectively remove ZEN contamination in the feed and protect the mice against the toxic damage of ZEN. In conclusion, Bacillus velezensis A2 has great potential use as a microbial feed additive to detoxify the toxicity of zearalenone in production practice.

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Protective effect of Crocin against zearalenone-induced oxidative stress in liver and kidney of Balb/c mice

Cited by 28 publications

References 56 publications

Bacillus subtilis ANSB01G culture alleviates oxidative stress and cell apoptosis induced by dietary zearalenone in first-parity gestation sows

Bacillus subtilis ANSB01G culture alleviates oxidative stress and cell apoptosis induced by dietary zearalenone in first-parity gestation sows

Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts

The Protective Role of Bacillus velezensis A2 on the Biochemical and Hepatic Toxicity of Zearalenone in Mice

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