2016
DOI: 10.1371/journal.pone.0146429
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Abstract: AimsIschaemic heart disease is most prevalent in the ageing population and often exists with other comorbidities; however the majority of laboratory research uses young, healthy animal models. Several recent workshops and focus meetings have highlighted the importance of using clinically relevant models to help aid translation to realistic patient populations. We have previously shown that mice over-expressing the creatine transporter (CrT-OE) have elevated intracellular creatine levels and are protected again… Show more

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Cited by 10 publications
(8 citation statements)
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“… 15 Notably, this approach also offered cardio-protection in the presence of co-morbidities such as old age and cardiac hypertrophy. 34 …”
Section: Discussionmentioning
confidence: 99%
“… 15 Notably, this approach also offered cardio-protection in the presence of co-morbidities such as old age and cardiac hypertrophy. 34 …”
Section: Discussionmentioning
confidence: 99%
“…Previously reported murine global ischemia-reperfusion injury models are significantly shorter, ranging from 20 to 45 min followed by varying reperfusion periods. 1114 Prolongation of ischemic time was necessary to establish a significant injury given the presence of highly effective hyperkalemic CPG. This study describes a novel global ischemic injury tailored to simulate the pathophysiology of prolonged global cardioplegic arrest during cardiopulmonary bypass.…”
Section: Discussionmentioning
confidence: 99%
“…Increasing myocardial creatine levels, [Cr], by 20–100 %, via over-expression of the plasma membrane creatine transporter (CrT; Slc6A8), protects the murine heart against ischaemia/reperfusion injury and improves functional recovery (Lygate et al 2012 ; Whittington et al 2016 ).…”
Section: Introductionmentioning
confidence: 99%