volume 9, issue 4, P1269-1279 2017
DOI: 10.18632/aging.101226
View full text
|
|
Share
Wendan Xu, Qian Zhu, Bei Zhang, Shan Liu, Xiaonan Dai, Chao Gao, Li Gao, Yugui Cui

Abstract: The core mechanism of Late-onset hypogonadism (LOH) is the deficiency of androgen due to the functional and quantitative decline of testicular Leydig cells. Here we explored the protective effect of calretinin, a Ca2+-binding protein, on Leydig cells. We found in MLTC-1 cells transfected with LV-calb2, the cell viability and optical density (OD) were higher (p<0.05), cells in the S phase of the cell cycle were increased (p<0.01) and p-ERK1/2 and p-AKT levels were significantly higher (p<0.01 and p<0.05), while…

expand abstract