1961
DOI: 10.1001/archderm.1961.01580180113017
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Protection from Sunlight in Vitiligo

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Cited by 19 publications
(6 citation statements)
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“…The skin's underlying mechanisms for decreasing its reactivity to further exposure are not fully established. While cutaneous hyperpigmentation has been considered as an obvious adaptation mechanism (7,11,12,20,21), it is recognized that other factors play a significant role (7,8,22) as is demonstrated by the adaptation experienced (8) in vitiliginous and albino skin (23). Factors implicated in photoadaptive responses include: the physical optical barriers to ultraviolet radiation of hyperkeratotic epidermis; thickening of the stratum corneum (6,7,24,25); and the formation of some photoproducts which absorb photons (26,27).…”
Section: Discussionmentioning
confidence: 99%
“…The skin's underlying mechanisms for decreasing its reactivity to further exposure are not fully established. While cutaneous hyperpigmentation has been considered as an obvious adaptation mechanism (7,11,12,20,21), it is recognized that other factors play a significant role (7,8,22) as is demonstrated by the adaptation experienced (8) in vitiliginous and albino skin (23). Factors implicated in photoadaptive responses include: the physical optical barriers to ultraviolet radiation of hyperkeratotic epidermis; thickening of the stratum corneum (6,7,24,25); and the formation of some photoproducts which absorb photons (26,27).…”
Section: Discussionmentioning
confidence: 99%
“…116 The importance of stratum corneum thickening in photoprotection has been demonstrated in patients with vitiligo who lack melanin in specific areas. 117 …”
Section: Epidermal Thicknessmentioning
confidence: 99%
“…Since melanin is photoprotective, the arguments runs that any increase in melanin will result in a greater degree of photoprotection. Nonpigmentary photoprotection is even less well understood mechanistically but, since photoprotection occurs in the absence of pigment (such as is seen in vitiligo) (Everett, 1961), then processes such as increase in the thickness of the stratum corneum and epidermis are thought to be causally important in the adaptive response (Pearse et al, 1987). Both pigment (melanin) and stratum corneum together with suprabasal keratinocytes contribute to the attenuation of UVR by the epidermis; the exact contribution of either in the resting state and in response to UVR is unclear.…”
mentioning
confidence: 99%