Protection effect of cerium oxide nanoparticles against radiation-induced acute lung injuries in rats

Kadivar, Fatemeh; Haddadi, Gholamhassan; Mosleh-Shirazi, Mohammad Amin; Khajeh, Fatemeh; Tavasoli, Alireza

doi:10.1016/j.rpor.2019.12.023

Cited by 18 publications

(11 citation statements)

References 25 publications

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“…These data are consistent with the authors’ earlier data on the antioxidant properties of CeO 2 nanoparticles, which showed that, at the concentration of 10 −5 M, they were able to effectively reduce the generation of radiation-induced hydrogen peroxide [ 30 ]. The redox properties of nanoceria enables it to work as a scavenger of reactive oxygen species (ROS) and free radicals, preventing the development of radiation-induced damage to cells, organs, and whole organisms [ 31 , 32 , 33 , 34 , 35 ]. It has previously been shown that nanoceria is capable of inactivating a wide range of radicals and ROSs, including the hydroxyl radical [ 36 ], nitroxyl radical [ 37 ], singlet oxygen [ 38 ], and superoxide anion radical [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Hybrid Polyelectrolyte Capsules Loaded with Gadolinium-Doped Cerium Oxide Nanoparticles as a Biocompatible MRI Agent for Theranostic Applications

Kolmanovich,

Chukavin,

Savintseva

et al. 2023

Polymers

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Layer-by-layer (LbL) self-assembled polyelectrolyte capsules have demonstrated their unique advantages and capability in drug delivery applications. These ordered micro/nanostructures are also promising candidates as imaging contrast agents for diagnostic and theranostic applications. Magnetic resonance imaging (MRI), one of the most powerful clinical imaging modalities, is moving forward to the molecular imaging field and requires advanced imaging probes. This paper reports on a new design of MRI-visible LbL capsules, loaded with redox-active gadolinium-doped cerium oxide nanoparticles (CeGdO2−x NPs). CeGdO2−x NPs possess an ultrasmall size, high colloidal stability, and pronounced antioxidant properties. A comprehensive analysis of LbL capsules by TEM, SEM, LCSM, and EDX techniques was carried out. The research demonstrated a high level of biocompatibility and cellular uptake efficiency of CeGdO2−x-loaded capsules by cancer (human osteosarcoma and adenocarcinoma) cells and normal (human mesenchymal stem) cells. The LbL-based delivery platform can also be used for other imaging modalities and theranostic applications.

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Section: Resultsmentioning

confidence: 99%

Hybrid Polyelectrolyte Capsules Loaded with Gadolinium-Doped Cerium Oxide Nanoparticles as a Biocompatible MRI Agent for Theranostic Applications

Kolmanovich,

Chukavin,

Savintseva

et al. 2023

Polymers

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“…[93] Moreover, CeO 2 NPs can also enhance the antioxidant capacity of cells by activating the Nrf2 signaling pathway to upregulate the production and release of intracellular antioxidant substances. [117] CeO 2 NPs can activate cell proliferation and growth by regulating various signaling pathways, including PI3K/Akt, ERK/MAPK, and Wnt/𝛽-catenin. [142] It has been shown that CeO 2 NPs can also increase the protein content and mechanical strength of the extracellular matrix and improve cell adhesion and survival, thereby promoting cell proliferation and growth.…”

Section: Cerium Oxide Nanoparticlesmentioning

confidence: 99%

Section: Therapeutic Care Modalities For Prevention and Each Type Of ...mentioning

confidence: 99%

Radiation Skin Injury Care in Radiotherapy for Oncology: Mechanisms, Drug Therapy and Novel Biomaterial Application Strategies

Wang

Yang

Liu

et al. 2023

Advanced Therapeutics

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Radiation skin injury (RSI) is a frequent adverse effect of radiation therapy for malignant tumors. It often leads to problems such as decreased quality of life in patients and interferes with the normal course of radiation therapy (RT). With the rising incidence of tumors and the burgeoning number of patients undergoing RT, the care of RSI is of crucial importance in cancer patient treatment. Currently, drugs and biomaterials are widely used in the care of RSI. However, there is no international consensus on the current protocol for the therapeutic care of RSI. Many drugs and biomaterials cannot be applied to the appropriate type of radiation dermatitis, resulting in unfavorable results in the therapeutic care of RSI. The choice of appropriate drugs and biomaterials for the therapeutic care of the different types of RSI is essential to improving the quality of life of patients. This article first reviews the main mechanisms of acute and chronic RSI. Subsequently, the application of drugs and novel biomaterials in the preventive, acute, and chronic phases of the care of RSI is summarized. Finally, the suggestions and protocols for the application of novel biomaterials in the care of RSI are discussed, as are the current challenges and future prospects for the development of combined biomaterials and integrated care solutions.

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“…Among the many applications of their radical scavenging properties, one of the most promising is protecting normal tissues during radiation therapy. CONPs have been shown under many conditions to be excellent radioprotectors of several normal tissue types [ 26 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. For example, in similar studies assessing radioprotection of normal cell culture lines, CONPs were able to increase the cell viability of fibroblasts by 20% following 6 MV photon irradiation to 4 Gy and of epithelial cells by 27% following 18 MV photon irradiation to 3 Gy [ 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

“…CONPs given i.p. to mice before irradiation of the thorax to 18 Gy using 6 MV photons were able to significantly reduce neutrophile aggregation and lung tissue collapse [ 35 ]. A similar study of mice treated with i.p.-injected CONPs prior to 15 Gy thorax irradiation with 320 kV photons showed that CONPs decreased lung structural damage, collagen deposition, inflammation, and vascular damage compared to control mice [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Imaging Investigations of Polymer-Coated Cerium Oxide Nanoparticles as a Radioprotective Therapeutic Candidate

et al. 2023

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Cerium oxide nanoparticles (CONPs) have a unique surface redox chemistry that appears to selectively protect normal tissues from radiation induced damage. Our prior research exploring the biocompatibility of polymer-coated CONPs found further study of poly-acrylic acid (PAA)-coated CONPs was warranted due to improved systemic biodistribution and rapid renal clearance. This work further explores PAA-CONPs’ radioprotective efficacy and mechanism of action related to tumor microenvironment pH. An ex vivo TUNEL assay was used to measure PAA-CONPs’ protection of the irradiated mouse colon in comparison to the established radioprotector amifostine. [18F]FDG PET imaging of spontaneous colon tumors was utilized to determine the effects of PAA-CONPs on tumor radiation response. In vivo MRI and an ex vivo clonogenic assay were used to determine pH effects on PAA-CONPs’ radioprotection in irradiated tumor-bearing mice. PAA-CONPs showed excellent radioprotective efficacy in the normal colon that was equivalent to uncoated CONPs and amifostine. [18F]FDG PET imaging showed PAA-CONPs do not affect tumor response to radiation. Normalization of tumor pH allowed some radioprotection of tumors by PAA-CONPs, which may explain their lack of tumor radioprotection in the acidic tumor microenvironment. Overall, PAA-CONPs meet the criteria for clinical application as a radioprotective therapeutic agent and are an excellent candidate for further study.

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Protection effect of cerium oxide nanoparticles against radiation-induced acute lung injuries in rats

Cited by 18 publications

References 25 publications

Hybrid Polyelectrolyte Capsules Loaded with Gadolinium-Doped Cerium Oxide Nanoparticles as a Biocompatible MRI Agent for Theranostic Applications

Hybrid Polyelectrolyte Capsules Loaded with Gadolinium-Doped Cerium Oxide Nanoparticles as a Biocompatible MRI Agent for Theranostic Applications

Radiation Skin Injury Care in Radiotherapy for Oncology: Mechanisms, Drug Therapy and Novel Biomaterial Application Strategies

Molecular Imaging Investigations of Polymer-Coated Cerium Oxide Nanoparticles as a Radioprotective Therapeutic Candidate

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