Protection against paracetamol-induced hepatotoxicity by acetylsalicylic acid in rats

Piroxicam and meloxicam ameliorate hepatic oxidative stress and protein carbonylation in Kupffer and sinusoidal endothelial cells promoted by ischemia-reperfusion injury

“…These results are in agreement with our previous work that showed a hepato‐protective action of other NSAIDs in preventing certain deleterious effects of acute ethanol intoxication [30–32]. The hepato‐protective action of aspirin on acetaminophen‐induced liver injury has been reported by other authors [54,55]. In this regard, the work of Imaeda et al.…”

Piroxicam and meloxicam ameliorate hepatic oxidative stress and protein carbonylation in Kupffer and sinusoidal endothelial cells promoted by ischemia-reperfusion injury

“…These results are in agreement with our previous work that showed a hepato‐protective action of other NSAIDs in preventing certain deleterious effects of acute ethanol intoxication [30–32]. The hepato‐protective action of aspirin on acetaminophen‐induced liver injury has been reported by other authors [54,55]. In this regard, the work of Imaeda et al.…”

Acetaminophen hepatotoxicity: Is there a role for prostaglandin synthesis?

“…It would have been possible to assume that partial inhibition of cytochrome P450-mediated oxidation of APAP by indomethacin and aspirin could contribute to their activity in reducing APAP hepatotoxicity. However, contrary to imidazole, the NSAIDs did not affect the APAP-induced GSH depletion, as was also reported for other species (De Vries et al 1984;Madhu et al 1989). Therefore, one must conclude that the protective action of NSAIDs should be exerted at a stage subsequent to the formation of active metabolite and GSH conjugation (Kosower and Kosower 1978;Sies et al 1980;Hinson et al 1982).…”

“…Other authors reported protection with much larger doses of aspirin (Whitehouse et al 1976;De Vries et al 1984). Apart from the well established effect of NSAIDs as cyclooxygenase inhibitors, indomethacin has been shown to inhibit rat hepatic aminopyrine N-demethylase, ethoxyresorufin O-deethylase and other mixed function oxidases (Vukoson et al 1978;Burke et al 1983;Falzon et al 1984).…”

Reduction by acetylsalicylic acid of paracetamol-induced hepatic glutathione depletion in rats treated with 4,4‘-dichlorobiphenyl, phenobarbitone and pregnenolone-16-α-carbonitrile

“…Furthermore, those of our animals receiving overdoses of paracetamol or ASA suffered from severe liver or gastric injury, respectively. However, a previous study has demonstrated that both simultaneous and delayed treatment with ASA reduced the paracetamol-induced liver toxicity (De Vries et al 1984). Moreover, the protective action of paracetamol against the gastric damage provoked by ASA has been well documented (Seegers et a1 1978).…”

Piroxicam and meloxicam ameliorate hepatic oxidative stress and protein carbonylation in Kupffer and sinusoidal endothelial cells promoted by ischemia-reperfusion injury

“…These results are in agreement with our previous work that showed a hepato‐protective action of other NSAIDs in preventing certain deleterious effects of acute ethanol intoxication [30–32]. The hepato‐protective action of aspirin on acetaminophen‐induced liver injury has been reported by other authors [54,55]. In this regard, the work of Imaeda et al.…”

Acetaminophen hepatotoxicity: Is there a role for prostaglandin synthesis?

“…It would have been possible to assume that partial inhibition of cytochrome P450-mediated oxidation of APAP by indomethacin and aspirin could contribute to their activity in reducing APAP hepatotoxicity. However, contrary to imidazole, the NSAIDs did not affect the APAP-induced GSH depletion, as was also reported for other species (De Vries et al 1984;Madhu et al 1989). Therefore, one must conclude that the protective action of NSAIDs should be exerted at a stage subsequent to the formation of active metabolite and GSH conjugation (Kosower and Kosower 1978;Sies et al 1980;Hinson et al 1982).…”

“…Other authors reported protection with much larger doses of aspirin (Whitehouse et al 1976;De Vries et al 1984). Apart from the well established effect of NSAIDs as cyclooxygenase inhibitors, indomethacin has been shown to inhibit rat hepatic aminopyrine N-demethylase, ethoxyresorufin O-deethylase and other mixed function oxidases (Vukoson et al 1978;Burke et al 1983;Falzon et al 1984).…”

Reduction by acetylsalicylic acid of paracetamol-induced hepatic glutathione depletion in rats treated with 4,4‘-dichlorobiphenyl, phenobarbitone and pregnenolone-16-α-carbonitrile

“…Furthermore, those of our animals receiving overdoses of paracetamol or ASA suffered from severe liver or gastric injury, respectively. However, a previous study has demonstrated that both simultaneous and delayed treatment with ASA reduced the paracetamol-induced liver toxicity (De Vries et al 1984). Moreover, the protective action of paracetamol against the gastric damage provoked by ASA has been well documented (Seegers et a1 1978).…”

Piroxicam and meloxicam ameliorate hepatic oxidative stress and protein carbonylation in Kupffer and sinusoidal endothelial cells promoted by ischemia-reperfusion injury

“…These results are in agreement with our previous work that showed a hepato‐protective action of other NSAIDs in preventing certain deleterious effects of acute ethanol intoxication [30–32]. The hepato‐protective action of aspirin on acetaminophen‐induced liver injury has been reported by other authors [54,55]. In this regard, the work of Imaeda et al.…”

Acetaminophen hepatotoxicity: Is there a role for prostaglandin synthesis?

“…It would have been possible to assume that partial inhibition of cytochrome P450-mediated oxidation of APAP by indomethacin and aspirin could contribute to their activity in reducing APAP hepatotoxicity. However, contrary to imidazole, the NSAIDs did not affect the APAP-induced GSH depletion, as was also reported for other species (De Vries et al 1984;Madhu et al 1989). Therefore, one must conclude that the protective action of NSAIDs should be exerted at a stage subsequent to the formation of active metabolite and GSH conjugation (Kosower and Kosower 1978;Sies et al 1980;Hinson et al 1982).…”

“…Other authors reported protection with much larger doses of aspirin (Whitehouse et al 1976;De Vries et al 1984). Apart from the well established effect of NSAIDs as cyclooxygenase inhibitors, indomethacin has been shown to inhibit rat hepatic aminopyrine N-demethylase, ethoxyresorufin O-deethylase and other mixed function oxidases (Vukoson et al 1978;Burke et al 1983;Falzon et al 1984).…”

Reduction by acetylsalicylic acid of paracetamol-induced hepatic glutathione depletion in rats treated with 4,4‘-dichlorobiphenyl, phenobarbitone and pregnenolone-16-α-carbonitrile

“…Furthermore, those of our animals receiving overdoses of paracetamol or ASA suffered from severe liver or gastric injury, respectively. However, a previous study has demonstrated that both simultaneous and delayed treatment with ASA reduced the paracetamol-induced liver toxicity (De Vries et al 1984). Moreover, the protective action of paracetamol against the gastric damage provoked by ASA has been well documented (Seegers et a1 1978).…”