Protection against laryngeal and pharyngeal carcinoma: Heterozygous vs. homozygous deletions of GSTM1 and GSTT1

Masood, Nosheen; Kayani, Mahmood Akhtar

doi:10.1590/s1415-47572013005000006

Cited by 7 publications

(1 citation statement)

References 18 publications

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“…Meanwhile, individuals of Hispanic origin exhibit GSTT1 deletions at a rate of 10-12 percent (149)(150)(151)(152). In terms of ethnicity, Asians are more susceptible to HNC associated with GSTT1 null genotype, compared to their European and American counterparts (101). The present meta-analysis reported that GSTT1 polymorphism has an association with the risk of HNC in Asian and mixed ethnicities, not Caucasians.…”

Section: Discussionmentioning

confidence: 46%

Glutathione S-transferase theta 1 (GSTT1) deletion polymorphism and susceptibility to head and neck carcinoma according to 107 articles: A systematic review with five analyses

Sadafi,

Choubsaz,

Kazemeini

et al. 2023

Preprint

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GSTT1 enzyme plays a key role in the neutralization of electrophilic compounds such as carcinogens. Herein, we aimed to evaluate GSTT1 deletion polymorphism and susceptibility to head and neck carcinoma (HNC) according to 107 articles in a systematic review with five analyses. The databases of PubMed/Medline, Web of Science, Scopus, and Cochrane Library until June 21, 2023, with no restrictions to identify pertinent articles. The quality scoring was done using the Newcastle-Ottawa Scale (NOS) tool. The Review Manager 5.3 software was used to calculate the effect sizes, which were displayed as the odds ratio (OR) along with a 95% confidence interval (CI). Both the publication bias and sensitivity analyses were performed using the Comprehensive Meta-Analysis version 3.0 software. To mitigate the risk of false-positive or negative conclusions from meta-analyses, a trial sequential analysis (TSA) was conducted using TSA software.: Of 1966 records retrieved from four databases, 107 full-text articles were included in the analysis. The combined analysis revealed that the pooled OR was 1.28 (95% CI: 1.14 to 1.44; p-value < 0.0001). In terms of ethnicity, the pooled OR was highest in mixed ethnicities. For cancer type, nasopharyngeal cancer had the highest OR. When considering sample size, studies with less than 200 samples had a higher OR compared to those with 200 or more samples. The control source did not significantly affect the OR. The studies with a quality score of 7 or more had a higher OR compared to those with a score less than 7. When both age and sex are considered, while the OR of 1.42 is significant, the high heterogeneity suggests caution in interpreting these results. Finally, in the group where neither age nor sex was considered, no significant association was found. The p-values for both Egger’s test (0.904) and Begg’s test (0.237) are greater than 0.10. TSA reported that the study does not have sufficient statistical power. This comprehensive meta-analysis revealed a significant association between the GSTT1 null genotype and an increased risk of HNC, with variations based on factors such as ethnicity, cancer type, sample size, control source, and quality score.

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Section: Discussionmentioning

confidence: 46%

Glutathione S-transferase theta 1 (GSTT1) deletion polymorphism and susceptibility to head and neck carcinoma according to 107 articles: A systematic review with five analyses

Sadafi,

Choubsaz,

Kazemeini

et al. 2023

Preprint

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Genetic variations and head and neck cancer risks

2014

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Variations in CYP1A1, GSTM1, GSTT1 and GSTP1 in head and neck cancer have been frequently found in literature. But these studies give an overview of these genetic variations in different populations. The current mini review focus on the analysis of these genetic variations at DNA, mRNA and protein levels in the same study group. Eight publications were reviewed on the same study samples yielding results at DNA, mRNA and protein levels. At DNA level, CYP1A1 showed significantly higher mutations in head and neck cancer patients compared to controls at g.2842A>C and g.2842_2843insT. GSTM1 and GSTT1 showed deletion polymorphisms and heterozygous deletion confers protection against cancer. Mutations were also found in GSTP1 at g.2848A>T, g.2849G>A, g.1074delC and g.1466delC. mRNA and protein expressional analysis revealed underexpression of CYP1A1, loss or underexpression of GSTM1 and GSTT1 and overexpression of GSTP1. In addition an unusual intronic variant of GSTP1 mRNA was also found, retaining the intronic portion between exons. The current review gives a complete study overview regarding CYP1A1, GSTM1, GSTT1 and GSTP1 variations at DNA, mRNA and protein levels in head and neck cancer. The review is helpful in designing a new experiment or gene therapy for head and neck cancer patients.

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Glutathione S-transferase T1 null genotype and laryngeal cancer risk: a meta-analysis

Liu

2014

Tumor Biol.

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Glutathione S-transferase T1 (GSTT1) polymorphic variation has been implicated as a risk factor for various cancers. However, previous studies investigating the association between GSTT1 null genotype and laryngeal cancer risk in Asians reported conflicting outcomes. In the present study, the possible association of laryngeal cancer risk with GSTT1 null genotype was explored by a meta-analysis. Relevant studies were identified through a systemic search of PubMed and Chinese National Knowledge Infrastructure databases. Six studies with a total of 1,824 individuals were included in the meta-analysis. The pooled odds ratio (OR) with 95 % confidence interval (CI) was used to assess the association. Meta-analysis of all included studies showed that there was an obvious association between GSTT1 null genotype and laryngeal cancer risk in Asians (OR = 2.41, 95 % CI 1.27-4.57, P = 0.007, I (2) = 86 %). After adjusting for heterogeneity, there was still an obvious association between GSTT1 null genotype and laryngeal cancer risk in Asians (OR = 1.75, 95 % CI 1.36-2.24, P < 0.001, I (2) = 0 %). The findings from the meta-analysis suggest that GSTT1 null genotype is associated with laryngeal cancer risk in Asians.

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Protection against laryngeal and pharyngeal carcinoma: Heterozygous vs. homozygous deletions of GSTM1 and GSTT1

Cited by 7 publications

References 18 publications

Glutathione S-transferase theta 1 (GSTT1) deletion polymorphism and susceptibility to head and neck carcinoma according to 107 articles: A systematic review with five analyses

Glutathione S-transferase theta 1 (GSTT1) deletion polymorphism and susceptibility to head and neck carcinoma according to 107 articles: A systematic review with five analyses

Genetic variations and head and neck cancer risks

Glutathione S-transferase T1 null genotype and laryngeal cancer risk: a meta-analysis

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