“…Also, the spectrum of the valve noise can be analyzed, as is done, for example, in Masson & Rieu (1998). Experimental in vivo testing is another option, using echocardiography and Doppler ultrasound to investigate the behavior of the valve after implantation in human patients (Bech-Hanssen, 2001;Aslam et al, 2007;Aljassim et al, 2008;Zogbi et al, 2009) or in animals (Yin et al, 2006). Numerical ("in silico") methods can provide an alternative way to obtain relevant and detailed information for valve design optimization, since they are capable of solving the valve dynamics with a high degree of resolution in time and space (Kelly et al, 1999;Grigioni et al, 2004;Yoganathan et al, 2005;Dasi et al, 2009;Sotiropoulous & Borazjani, 2009).…”