Prostate Cancer Detection at Low Prostate Specific Antigen

Schröder, Fritz H.; Cruijsen-Koeter, Ingrid van der; Koning, Harry J. de; Vis, André N.; Hoedemaeker, Robert F.; Kranse, Ries

doi:10.1016/s0022-5347(05)67809-3

Cited by 281 publications

(124 citation statements)

References 34 publications

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“…The T-PSA levels are very useful for screening patients who need prostate biopsy in the early screening for prostate cancer; however, there is limitation in distinguishing patients who do not have a high risk of prostate cancer [31]. Therefore, there have been attempts to develop, quantify, and apply other available markers such as prostate specific antigen density (PSAD), prostate specific antigen velocity (PSAV),, and F/T PSA ratios in patients.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Multiple Intravenous Administration of Cultured Human Autologous Adipose-Derived Stem Cells on Tumor Biomarker Levels

Chang-hyun¹,

Kim²,

Kim³

2017

J Clin Case Rep

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Many studies have been conducted to cultivate and utilize patients' own adipose-derived stem cells for the treatment of various incurable diseases and for regenerative medicine that can prolong lifespan. Despite the significant achievements made thus far, the lack of confidence with regard to safety, particularly the concern about tumorigenicity, has made researchers hesitant to actively apply cultured human autologous adipose-derived cells in clinical trials. Therefore, studies on the tumorigenicity of cultured adipose-derived stem cells are very important for expanding the field of stem cell-utilizing regenerative medicine. It is also important to study their effect on tumor biomarker levels. Long-term follow-up studies of tumorigenicity after multiple intravenous administrations of cultured human autologous adipose-derived stem cells have not been reported worldwide. Therefore, the authors have examined 462 Koreans who were administered more than 1 billion cultured autologous adipose-derived stem cells multiple times from 2010 to 2013 at medical institutions in Japan. We then conducted the first retrospective research in the world on the changes in eight types of tumor biomarkers over three-six years. According to the results of our analysis, there were no significant changes in the observed tumor biomarkers, irrespective of gender and age. These results suggest that multiple administrations of autologous adipose-derived stem cells cultured in accordance with the authors' method do not affect tumorigenicity.

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Section: Discussionmentioning

confidence: 99%

Effect of the Multiple Intravenous Administration of Cultured Human Autologous Adipose-Derived Stem Cells on Tumor Biomarker Levels

Chang-hyun¹,

Kim²,

Kim³

2017

J Clin Case Rep

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“…26 Therefore, a better evaluation of men with low tPSA concentrations has been recommended to improve the early detection of prostate cancer. 26 Thus, a pre-selection of patients with possible prostate cancer from men without cancer at these low PSA concentrations is absolutely necessary in order to reduce unnecessary biopsies for final diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…13 In conclusion, our results show that despite the above-mentioned limitations, the fPSA/tPSA, PSA-ACT/tPSA or cPSA/tPSA ratios may meet the requirements to increase the selectivity of PCa detection at low PSA concentration. 26 As the fPSA/tPSA and cPSA/tPSA ratios yielded comparable diagnostic validity and the assays are commercially available, we would prefer one of those ratios rather than PSA-ACT determination. The ratios could be used in assessing the risk of PCa in the individual and therefore in deciding on the prostate biopsy for final diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Molecular forms of prostate-specific antigen in serum with concentrations of total prostate-specific antigen <4 ?g/L: Are they useful tools for early detection and screening of prostate cancer?

et al. 2001

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Molecular forms of prostate-specific antigen (PSA) improve the differentiation between benign prostatic hyperplasia (BPH) and prostate cancer (PCa) in men with total PSA concentrations between 4 and 10 g/l. To evaluate the diagnostic utility of free PSA (fPSA) and complexed PSA forms for identification of men with PCa in the low PSA range of <4 g/l, total PSA (tPSA), ␣ 1 -antichymotrypsin complexed PSA (PSA-ACT) and fPSA (Roche Elecsys [ES] system) as well as tPSA and complexed PSA (cPSA) (Bayer Immuno 1 system) were measured in archival serum samples from 31 untreated patients with PCa, 66 patients with BPH, and 90 men without prostatic disease. The median ratios of fPSA/tPSA, PSA-ACT/tPSA and cPSA/tPSA were significantly different between patients with BPH and PCa (27.2 vs. 19.4%, 64 vs. 88%, 77.2 vs. 88.2%, p < 0.05). No associations between PSA forms and tumor stage and grade were found. Analysis of the receiver operating characteristic curves showed that these ratios could discriminate better between BPH and PCa patients than determination of the analytes tPSA, fPSA, cPSA and PSA-ACT alone. The use of one of the ratios would have eliminated roughly half of the unnecessary biopsies in this study. The ratios should be considered as potential tools to increase the selectivity of PCa detection at low PSA concentration. The ratios fPSA/tPSA and cPSA/tPSA can be determined using commercially available assays so that one of these ratios could be preferred instead of PSA-ACT determination. The ratios could be useful in assessing the risk of PCa in the individual and therefore in deciding on prostate biopsy for final diagnosis.

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“…Improvement of this technology has provided high accuracy to define mass-to-charge ratio (m/z) and to generate high resolution spectra (Pavlou and Diamandis, 2009;Schroder et al, 2000). A metabolomic approach seems a promising challenge, as tumor cells exhibit defined changes in their metabolism, for non-invasive diagnosis and prognostic evaluation of prostate cancer (Prensner et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Untargeted LC-QTOF (ESI +) MS Analysis of Small Serum Metabolites Related to Prostate Cancer and Prostate Specific Antigen

Maxim¹,

Socaciu²,

Pop³

et al. 2014

BUASVMCN-FST

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Prostate cancer has an increasing incidence and there is an urgent need for development of new serum biomarkers for early diagnostic as the ones known are ineffective. The aim of the study was to use untargeted metabolomics in order to identify and characterize small metabolite fingerprints in patients with normal vs pathologic values of PSA ( previously determined by electrochemiluminiscence).A cohort of one hundred patients with different Prostate Specific amtigen values were investigated by untargeted metabolomics. The serum small metabolite profile determined by high performance liquid chromatography coupled with mass spectrometry, LC-QTOF(ESI + )MS in order to identify specific biomarkers, for normal patient group (PSA = 0-4 ng.ml) and four pathologic groups, having PSA values from 4 to >1000 ng/ml.The major molecules identified in the samples were polar phospholipids, maily lysophosphatidyl choline derivatives, having m/z values from 496 to 524, like LPC(O-16:0/O-1:0), LPC(18:1/2:0) or PS(18:1(9Z)/0:0), LPC(18:2(9Z,12Z)/0:0 and their isomers and LPC(O-18:1(11Z)/2:0), respectively. Also, small molecules (free fatty acids and prostaglandin derivatives) were identified and are significantly different in pathologic vs normal serum samples. Generally the pathologic samples had increased concentrations of all above mentioned molecules. The Principal Component analysis showed , by plot and loadings scores, significant clustering of normal vs pathological groups.

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Prostate Cancer Detection at Low Prostate Specific Antigen

Cited by 281 publications

References 34 publications

Effect of the Multiple Intravenous Administration of Cultured Human Autologous Adipose-Derived Stem Cells on Tumor Biomarker Levels

Effect of the Multiple Intravenous Administration of Cultured Human Autologous Adipose-Derived Stem Cells on Tumor Biomarker Levels

Molecular forms of prostate-specific antigen in serum with concentrations of total prostate-specific antigen <4 ?g/L: Are they useful tools for early detection and screening of prostate cancer?

Untargeted LC-QTOF (ESI +) MS Analysis of Small Serum Metabolites Related to Prostate Cancer and Prostate Specific Antigen

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